CAS: 10526-80-4; Phospho(Enol)Pyruvic Acid Cyclohexylammonium Salt

相似化合物

1198355-02-0 123334-13-4 3070116-25-2

专利信息

专利号:US-2024391961-A1
优先权日:2021-08-25
标题:Autonomous organisms for synthesis of permanently phosphorylated proteins
发明人：COOLEY RICHARD B; MEHL RYAN A; ZHU PHILLIP
权利人:UNIV OREGON STATE
摘要:Embodiments of the present disclosure provide compositions and methods for biosynthesizing a stable, functional mimic of phosphoserine. The compositions and methods described herein genetically program a host cell to express a biosynthetic pathway that can synthesize the amino acid, 2-amino-4-phosphobobutyric acid, that is a non-hydrolyzable phosphoserine (nhpSer) because it contains a carbon-phosphorus, e.g., phosphonate, bond. In one embodiment the genetically programed cells express the enzymes of a pathway from a Streptomyces bacterium . In some embodiments, nhpSer is translationally incorporated into protein of interest at one or more programmed UAG amber codons using Genetic Code Expansion (GCE) technology.

专利号:US-11781122-B2
优先权日:2017-07-11
标 题:Ectoine-producing yeast
发明人：LOUIS DOMINIQUE; JAILLARDON KARINE; THOMAS DOMINIQUE
权利人:ALDERYS; GIVAUDAN SA
摘要:The present invention relates to the field of bio-production of ectoine. There is a need in the art for ectoine production methods allowing its highly efficient synthesis and secretion. The solution proposed in the present invention is the use of a genetically modified yeast comprising many modifications as described in the present text.