专利号:WO-2024260915-A1 优先权日:2023-06-19 标题:Dynamic covalent chemistry of spiropyrans for synthesis of photoswitchable photoinitiators and uses thereof 发明人:GARMSHAUSEN YVES 权利人:XOLO GMBH 摘要:The present invention relates to spiropyrans and process for the manufacture of them. In particular, a method is provided to exchange the indole and salicylaldehyde part of a spiropyran in a reversible reaction. The method is used for the synthesis of dual color photoinitiators with specific substituents and substitution patterns, which result in improved dual color volumetric printing (xolography). Furthermore, a process for locally polymerizing a starting material by dual color photopolymerization is disclosed.
专利号:EP-3800178-A1 优先权日:2019-10-01 标题:Preparation of enamide intermediate for the synthesis of dasotraline 发明人:BALLETTE ROBERTO; DOBARRO RODRÃ?GUEZ ALICIA 权利人:MOEHS IBERICA SL 摘要:The present invention relates to a process for the preparation of N -(( S )-4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1-yl)acetamide, which is a suitable intermediate for the synthesis of dasotraline or a pharmaceutically acceptable salt thereof, as well as to a process for the preparation of dasotraline or a pharmaceutically acceptable salt thereof using said N -(( S )-4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1-yl)acetamide intermediate.
专利号:US-9703192-B2 优先权日:2012-09-15 标 题:Onium compounds and methods of synthesis thereof 发明人:LABEAUME PAUL J 权利人:ROHM & HAAS ELECT MAT 摘要:New onium salt compounds and methods for synthesis of such compounds are provided. Preferred methods of the invention include (a) providing an onium salt compound comprising a sulfonate component having an electron withdrawing group; and (b) treating the onium salt compound with a halide salt to form a distinct salt of the onium compound. The present onium compounds are useful as an acid generator component of a photoresist composition.
专利号:US-2005080260-A1 优先权日:2003-04-22 标 题 :Preparation of prodrugs for selective drug delivery 发明人:MILLS RANDELL L; WU GUO-ZHANG 摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.
专利号:WO-2008028772-A1 优先权日:2006-09-06 标 题:Bioquinones for stimulating keratin synthesis 发明人:GIESEN MELANIE; SCHULZE ZUR WIESCHE ERIK; POPPE ELISABETH; WELSS THOMAS 权利人:HENKEL KGAA; GIESEN MELANIE; SCHULZE ZUR WIESCHE ERIK; POPPE ELISABETH; WELSS THOMAS 摘要:The present invention relates to the cosmetic use of one or more bioquinones for combating age-related changes in the hair follicles, for the promotion of keratin synthesis in the hair, and for positively influencing the structure of the hair. The invention further relates to a cosmetic method for combating age-related changes in the hair follicle, and to a method for stimulating keratin synthesis in hair.
专利号:US-2016293932-A1 优先权日:2015-03-30 标题 :Synthetic methods for transition metal coordination compounds 发明人:MOTALLEBI SHAHROKH; RISSET OLIVIA NATHALIE; WESSELLS COLIN DEANE 权利人:ALVEO ENERGY INC 摘要:A system and method for controlling particle morphology of transition metal coordination compounds (TMCC). Synthesis of TMCC using one of several chelating agents having carboxylate chemical groups. These carboxylate groups bind to copper during the synthesis of the CuHCF TMCC materials, resulting in controlled particle growth, rather than rapid formation of many small nanoparticles as is the case without any chelating agent present. The materials produced using chelating agents of these embodiments such as these are composed of larger particles, making them easier to process into battery electrodes via standard methods such as slurry mixing and coating. The resulting electrodes retain the good electrochemical cycling performance of the control material synthesized without a chelating agent.
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