CAS: 98968-72-0; Tert-Butyl (2-Fluorophenyl)Carbamate

上下游产品

2-Fluoroaniline tert-butyl dicarbonatedi-tert-butyl dicarbonate tert-Butyl N-hydroxycarbamateN-(tert-butoxycarbonyl)-2-fluoro-6-methylaniline 2-(tert-Butoxycarbonylamino)-3-fluoro-benzoic acid tert-butyl N-(2-formyl-6-fluorophenyl)carbamate (2-fluoro-6-iodophenyl)carbamic acid tert-butyl ester

📜Tert-Butyl ((2-Fluorobenzoyl)Oxy)Carbamate置于bis-Triphenylphosphine-Palladium(II) Chloride,Caesium Carbonate体系中,用 氯苯 作为反应溶剂,化学反应 1.0H,以70%的收率获得产物n-Boc-2-氟苯胺
参考文献:钯催化芳胺的脱羧合成
标题:钯催化芳胺的脱羧合成
摘要:已经开发出一种新的方法,用于通过芳基羧酸与羟基氨基甲酸酯在原位获得的钯催化的芳酰氧基氨基甲酸酯的分子内脱羧偶联(idc)来合成芳基胺.该反应提供了在温和条件下以特定位置形成c(sp 2)-N键的结构多样的芳基胺的便捷通道.
DOI:10.1021/acs.Orglett.6B02724

专利信息

专利号:US-7157604-B2
优先权日:2001-08-13
标题:Selective estrogen receptor modulators
发明人：MENG DONGFANG; PARKER JR DANN LEROY; WILKENING ROBERT R; RATCLIFFE RONALD W
权利人:MERCK & CO INC
摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.

专利号:EP-1339683-B1
优先权日:2000-11-27
标题 :Estrogen receptor modulators
发明人：WILKENING ROBERT R; PARKER DANN LEROY JR; WILDONGER KENNETH J; MENG DONGFANG; RATCLIFFE RONALD W
权利人:MERCK & CO INC
摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restinosis, gynacomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.

专利号:US-8378104-B2
优先权日:2010-02-11
标 题 :7-aminofuropyridine derivatives
发明人：HORNBERGER KEITH R; BERGER DAN M; CHEN XIN; CREW ANDREW P; DONG HANQING; KLEINBERG ANDREW; LI AN-HU; MA LIFU; MULVIHILL MARK J; PANICKER BIJOY; SIU KAM W; STEINIG ARNO G; TARRANT JAMES G; WANG JING; WENG QINGHUA; SANGEM RAJARAM; GUPTA RAMESH C
权利人:OSI PHARMACEUTICALS LLC; HORNBERGER KEITH R; BERGER DAN M; CHEN XIN; CREW ANDREW P; DONG HANQING; KLEINBERG ANDREW; LI AN-HU; MA LIFU; MULVIHILL MARK J; PANICKER BIJOY; SIU KAM W; STEINIG ARNO G; TARRANT JAMES G; WANG JING; WENG QINGHUA; SANGEM RAJARAM; GUPTA RAMESH C
摘要:Compounds of Formula 1, as shown below and defined herein: n n n n n n n n n n n n pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by TAK1 or for which an appropriate TAK1 inhibitor is effective. This Abstract is not limiting of the invention.