CAS: 97-18-7; 6,6'-Thiobis(2,4-Dichlorophenol)

上下游产品

CAS号120-83-2 2,4-二氯苯酚 | CAS号75-15-0 二硫化碳 | CAS号7446-70-0 氯化铝 | CAS号56-23-5 四氯化碳 | CAS号844-26-8 氧硫氯酚 | CAS号4568-36-9 2,4-dichloro-6-...

2,4-二氯酚置于aluminum (Iii) Chloride,氯化亚砜,溶剂黄146,锌体系中,用 二氯甲烷 作为反应溶剂,化学反应 12.0H,反应生成 硫氯酚
参考文献:A Selective Membrane-Targeting Repurposed Antibiotic With Activity Against Persistent Methicillin-Resistant Staphylococcus Aureus
标题:A Selective Membrane-Targeting Repurposed Antibiotic With Activity Against Persistent Methicillin-Resistant Staphylococcus Aureus
摘要:治疗由产生非生长持久菌体形式的甲氧西林耐药金黄色葡萄球菌(Mrsa)引起的感染缺乏有效的治疗方法.虽然破坏细胞膜的药物可以杀死持久菌体,但由于对细菌和哺乳动物膜的选择性较低,其治疗潜力一直被忽视.我们报告了临床上批准的驱虫药物双硫仑可以以对哺乳动物细胞毒性较低的浓度破坏膜脂双层来杀死mrsa持久菌体.双硫仑的选择性是由于哺乳动物膜中含有胆固醇,而细菌膜中没有.我们还表明,膜活性抗微生物药物的抗持久菌体效力与它们增加膜流动性的能力有关.我们的结果显著增强了我们对细菌膜破坏和膜选择性的理解.
DOI:10.1073/pnas.1904700116

专利信息

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:US-2024401154-A1
优先权日:2023-06-01
标 题 :Synthesis and preparation of ultra-low viscosity and high magnetic susceptibility magnetic ionic liquids
发明人：ANDERSON JARED L; ABBASI NABEEL MUJTABA; ZEGER VICTORIA; DE SILVA SHASHINI
权利人:UNIV IOWA STATE RES FOUND INC
摘要:This disclosure relates to a method and kit for capturing, concentrating, and detecting microbes in a sample using magnetic ionic liquids (MILs) and recombinase polymerase amplification (RPA). Specifically, a method combining magnetic ionic liquid (MIL)-based sample preparation and Recombinase Polymerase Amplification (RPA) for rapid detection of viable microbes in a sample is disclosed. The MILs employed comprise a DGE as the cationic ligand along with an anionic ligand.

专利号:US-9907753-B2
优先权日:2010-03-19
标 题 :Lipid vesicle compositions and methods of use
发明人：IRVINE DARRELL J; MOON JAEHYUN
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.

专利号:US-2007148246-A1
优先权日:2005-08-11
标题:Nucleic Acid-Based Matrixes
发明人：LUO DAN; LI YOUGEN
权利人:LUO DAN; LI YOUGEN
摘要:Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. Methods of utilizing such biomaterials include delivery of biologically active agents, cell and tissue culture, and cell-free protein synthesis.

专利号:WO-2021009026-A1
优先权日:2019-07-12
标 题 :Methyl 2-[(4-methoxyimino-tetralin-6-yl]prop-2-enoate derivatives, chromane, isochromane, 6,7,8,9-tetrahydrobenzo[7]annulene, 1h-isobenzofurane and indane analogues thereof, and similar compounds, as agrochemical fungicides
发明人：WEISS MATTHIAS; WILLIAMS SIMON; RENDINE STEFANO; BOU HAMDAN FARHAN; HOFFMAN THOMAS; QUARANTA LAURA
权利人:SYNGENTA CROP PROTECTION AG
摘要:Compounds of formula (I): (Formula (I)) Formula (I) encompasses e.g. tetraline, chromane, isochromane, 6,7,8,9-tetrahydrobenzo[7]annulene, 1H-isobenzofurane and indane derivatives. The compounds of formula (I) are useful as a pesticides, especially as fungicides. The present description discloses the synthesis and characterisation of exemplary compounds as well as biological data thereof (e.g. pages 53 to 78; examples 1 to 10; table T1; compounds 1.1 to 1.54; examples A and B). Preferred compounds are e.g.: Methyl (E)-3-methoxy-2-[(4E)-4-methoxyimino-7-methyl-tetralin-6- yl]prop-2-enoate (example 2; compound 1.6 of table T1): (Formula (A)). Methyl (E)-3-methoxy-2-[(4Z)-4-methoxyiminoisochroman-6-yl]prop-2- enoate (example 6; compound 1.39 of table T1): (Formula (B))

专利号:US-8486621-B2
优先权日:2005-08-11
标题 :Nucleic acid-based matrixes
发明人：LUO DAN; UM SOONG HO
权利人:LUO DAN; UM SOONG HO; CORNELL RES FOUNDATION INC
摘要:Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. Methods of utilizing such biomaterials include cell-free protein synthesis.