CAS: 917-54-4; Methyllithium

上下游产品

methyl bromide methylene chloride ethyllithium dimethylmercury1,1-dimethyl-1-silacyclohexane methane 2-(2-phenylethyl)pyridine 2,3,5-trimethyl-pyridine

氯甲烷置于sodium,Lithium体系中,用 乙醚 作为反应溶剂,化学反应 0.75H,以96%的收率获得产物甲基锂
参考文献:用于合成有机锂试剂的高活性锂金属枝晶的制备
标题:用于合成有机锂试剂的高活性锂金属枝晶的制备
摘要:有机锂化学领域的一个长期存在的问题是需要一种高反应性的锂金属源,它可以模拟锂粉,但具有由廉价且容易获得的锂源新鲜制备的优势.在这里,我们报告了一种使用液氨的简单方便的活化方法,该方法以结晶锂枝晶的形式提供了一种新的锂金属源.锂枝晶被证明具有约.比通过原型机械活化方法产生的传统锂源的表面积大 100 倍.随着表面积的增加,锂枝晶显示出比锂粉显着提高的速率,锂粉是目前制备有机锂化合物的行业标准.
DOI:10.1021/jacs.2C07207

专利信息

专利号:WO-2025053792-A1
优先权日:2023-09-06
标题:Collective synthesis of phantomolin family through total synthesis of the sesquiterpene lactone molephantin
发明人：CHIBA SHUNSUKE; PATOURET REMI HENRI LOUIS; LI HOI YEUNG; LAI SOAK KUAN
权利人:UNIV NANYANG TECH
摘要:Disclosed herein are processes to generate an intermediate in the total synthesis of (+)- molephantin or a derivative thereof, and a total synthesis of (+)-molephantin or a derivative thereof. Also disclosed herein are methods of forming a compound of formula XIV and of forming a compound of formula XV, wherein compound of formula XIV and compound of formula XV are as defined in the description.

专利号:US-3992439-A
优先权日:1972-04-17
标 题:Synthesis of prostaglandins of the 'one'-series
发明人：SCHAAF THOMAS K; COREY ELIAS J
权利人:PFIZER
摘要:In the synthesis of prostaglandins of the 'one' -series an alteration in the conventional reaction sequence avoids side reactions and provides an improved synthesis via a series of novel intermediates. In this improved synthesis the side chain at the 8 position is attached to the five membered ring before the side chain at the 12 position is attached.

专利号:US-4910310-A
优先权日:1988-10-03
标 题:Synthesis of N-substituted 1,5-dideoxy-1,5-imino-L-fucitol derivatives
发明人：CAMPBELL ARTHUR L; BEHLING JAMES R; BABIAK KEVIN A; NG JOHN S; MUELLER RICHARD A; FLEET GEORGE W J
权利人:SEARLE & CO
摘要:Novel intermediates and method for the chemical synthesis of N-substituted 1,5-dideoxy-1,5-imino-L-fucitol derivatives are provided. A preferred intermediate is 1,5-dideoxy-1,5-imino-3, 4-O-isopropylidene-L-fucitol which is used to prepare the HIV inhibitor 1,5-dideoxy-1,5-imino-[N-ω-methyl caproate]-L-fucitol. These compounds are prepared in a short synthesis from the known compound 2,3-O-isopropylidene-D-lyxono-1,4-lactone or in a multi-step synthesis from D-galactose.

专利号:US-4339388-A
优先权日:1980-04-22
标题 :Synthesis of periplanone-B
发明人：STILL W CLARK
权利人:STILL W CLARK
摘要:A synthesis of periplanone-B, a female sex pheromone of the American cockroach, P. americana, is described. Novel compounds which are useful as intermediates in the synthesis of periplanone-B are described including the precursor alcohol, periplanol-B.

专利号:US-5087703-A
优先权日:1988-01-28
标题 :Process for synthesis of FK-506 intermediates
发明人：VOLANTE RALPH P; ASKIN DAVID; SHINKAI ICHIRO; RYAN KENNETH M
权利人:MERCK & CO INC
摘要:A process is described for the synthesis of diastereomeric 2-methyl-4-hydroxy-5-protected-hydroxy-hept-6-en-prolinolamides, which are useful as intermediates in the synthesis of the C10-C18 chain of the macrolide structure for the immunosuppressant FK-506. These compounds are also useful as intermediates for preparing lactone ultraviolet radiation absorbers.

专利号:US-4185154-A
优先权日:1977-05-17
标 题 :Synthesis of vitamin E
发明人：OLSON GARY L; SAUCY GABRIEL
权利人:HOFFMANN LA ROCHE
摘要:A synthesis of Vitamin E has the condensation of 2,4-pentanediene and 1,2-epoxy-2,6,10,14-tetramethylpentadecane including intermediates in this synthesis which uses base catalyzed condensations of aliphatic compounds to construct the Vitamin E molecule from aliphatic precursors.