CAS: 90721-35-0; 5-Bromoisoquinolin-8-Amine

相似化合物

63927-23-1 16552-65-1 347146-30-9

上下游产品

CAS号63927-23-1 5-溴-8-硝基异喹啉 | CAS号34784-04-8 5-溴异喹啉 | CAS号679433-94-4 5-溴-8-氟异喹啉

📜5-溴-8-硝基异喹啉置于铁粉,氯化铵体系中,用 甲醇,水 作为反应溶剂,化学反应 3.0H,反应生成 5-溴-8-氨基异喹啉
参考文献: Inhibitors Of Jun N-Terminal Kinase[fr] Inhibiteurs De L'Enzyme Jun N-Terminal Kinase
标题: Inhibitors Of Jun N-Terminal Kinase[fr] Inhibiteurs De L'Enzyme Jun N-Terminal Kinase
摘要:本公开提供了具有以下结构的c-Jun N-末端激酶(jnk)抑制剂(i)的结构,或其盐或溶剂化物,其中环a,Ca,Cb,Z,R5,W和cy在此处定义.本公开还提供了包括本公开化合物的药物组合物,以及制备和使用本公开化合物和组合物的方法,例如在治疗和预防各种疾病,如阿尔茨海默病.

专利信息

专利号:US-2023183246-A1
优先权日:2020-05-19
标题 :Continuous flow sonogashira coupling synthesis method
发明人：THOMPSON DAVID HARLEY; SINTIM HERMAN O; QI QINGQING; BIYANI SHRUTI
权利人:PURDUE RESEARCH FOUNDATION
摘要:The present disclosure relates to a telescoped continuous flow Sonogashira coupling synthesis for some lead compounds to support in vivo studies and pre-clinical evaluation. The application of high throughput tools combined with the telescoped continuous synthesis method can enable an efficient and safe synthesis of compounds of interest involving hazardous coupling reagents such as HATU, while minimizing by-product formation.