CAS: 887266-99-1; 3-Fluoro-4-Iodobenzonitrile

上下游产品

CAS号1150114-77-4 4-氰基-2-氟苯基硼酸

3-氟-4-氨基苯腈置于对甲苯磺酸,Potassium Iodide,Sodium Nitrite体系中,用 乙腈,水 作为反应溶剂,化学反应 5.0H,以4.0 G的收率获得产物3-氟-4-碘苯腈
参考文献: Alkyne Compounds As S-Nitrosoglutathione Reductase Inhibitors[fr] Composés De Type Alcyne En Tant Qu'Inhibiteurs De La S-Nitrosoglutathione Réductase
标题: Alkyne Compounds As S-Nitrosoglutathione Reductase Inhibitors[fr] Composés De Type Alcyne En Tant Qu'Inhibiteurs De La S-Nitrosoglutathione Réductase
摘要:提供的是式(Ia)的化合物及其药学上可接受的盐,其中a,B,R1,R2,M和n如本文所定义,这些化合物作为s-硝基谷胱甘肽还原酶(Gsnor)的抑制剂具有活性.这些化合物可以预防,抑制或抑制gsnor的作用,因此在治疗gsnor介导的疾病,疾病,综合征或病症方面具有用处,例如肺动脉高压,急性呼吸窘迫综合征(Ards),哮喘,支气管痉挛,咳嗽,肺炎,肺纤维化,间质性肺疾病,囊性纤维化和慢性阻塞性肺疾病(Copd).

专利信息

专利号:WO-2025128848-A1
优先权日:2023-12-12
标题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

专利号:US-9868746-B2
优先权日:2012-02-23
标题:Substituted 5-aminothieno[2,3-C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; MELANCON BRUCE J; TARR JAMES C; SALOVICH JAMES M; POSLUSNEY MICHAEL S
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted 5-aminothieno[2,3-c]pyridazine-6-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 4 (mAChR M 4 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-8344010-B2
优先权日:2008-12-26
标 题 :Fused imidazole derivatives as TRPV3 antagonist
发明人：LINGAM V S PRASADARAO; THOMAS ABRAHAM; PHATANGARE SHANTARAM KASHINATH; MINDHE AJIT SHANKAR; KHATIK JAVED YUSUF; KHAIRATKAR-JOSHI NEELIMA; KATTIGE VIDYA GANAPATI
权利人:GLENMARK PHARMACEUTICALS SA; LINGAM V S PRASADARAO; THOMAS ABRAHAM; PHATANGARE SHANTARAM KASHINATH; MINDHE AJIT SHANKAR; KHATIK JAVED YUSUF; KHAIRATKAR-JOSHI NEELIMA; KATTIGE VIDYA GANAPATI
摘要:The present invention provides transient receptor potential vanilloid (TRPV) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.