CAS: 84380-10-9; (1S,2R)-1-((2R,3R,4S,6S)-3-Acetamido-4-Acetoxy-6-Hydroxy-6-(Methoxycarbonyl)Tetrahydro-2H-Pyran-2-yl)Propane-1,2,3-Triyl Triacetate

该化合物是一种复杂的碳水化合物衍生物,其特点是多乙基组,可提高其溶解性和稳定性.该化合物的特点是一种非氨酸结构,特别是一种3,5-dideoxy糖,在生物系统,特别是在石丙酮和甘油合成中具有重大意义. 乙基氨基氨基氨组的存在表明潜在的生物活动,可能影响与蛋白质或细胞膜的相互作用.四氧-O-辛基磺酸酶表明,所有氢氟基化合物都是乙基酰,可影响化合物在生物化学途径中的再活动与互动.该物质可能是一种合成中间或一种工具,用于研究碳水化合物-丙基化合物-丙基化学的化学特性.

英文名称(1S,2R)-1-((2R,3R,4S,6S)-3-Acetamido-4-Acetoxy-6-Hydroxy-6-(Methoxycarbonyl)Tetrahydro-2H-Pyran-2-yl)Propane-1,2,3-Triyl Triacetate
中文名称4,7,8,9-四-氧-乙酰基-N-神经氨酸甲酯
IUPAC名称(1S,2R)-1-((2R,3R,4S,6S)-3-acetamido-4-acetoxy-6-hydroxy-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yl)propane-1,2,3-triyl triacetate
其它别名4,7,8,9-Tetra-O-Acetyl-D-Neuraminic Acid Methyl Ester; Methyl4,7,8,9-Tetra-O-Acetyl-N-Acetylneuraminate; 4,7,8,9-Tetra-O-Acetyl-N-Acetylneuraminic Acid Methyl Ester; Methyl 5-Acetamido-4,7,8,9-Tetra-O-Acetyl-3,5-Dideoxy-D-Glycero-Beta-
CAS编号84380-10-9
MFCD编号:MFCD08276266
分子式:C20H29NO13分子量:491.45
产品CID: 1832278
产品分类生物化工 → 糖类化合物 → 单糖

相似结构搜索
InChIKey: CAKDMYCBPKFKCV-DCDDNHAVSA-N
CAKDMYCBPKFKCV-RPWHUKDHNA-N
计算化学: 氢键受体数13.0氢键供体数2.0可旋转键数14.0

MSDS等安全信息

警示词Warning
危险描述H302-H315-H319-
防范说明P264-P270-P280-P301+P312+P330-P302+P352-P305+P351+P338-P332+P313-P337+P313-P501-
WGK Germany3

上下游产品

合成工艺路线路线简述

📜N-Acetyl Neuraminic Acid置于dowex [50W-X8 (H+)]体系中,化学反应 32.0H,反应生成 4,7,8,9-四-O-乙酰基-N-乙酰神经氨酸甲酯
参考文献:Cmp-唾液酸衍生物的化学合成和酶促测试
标题:Cmp-唾液酸衍生物的化学合成和酶促测试
摘要:唾液酸修饰:Cyclo Sal核苷酸用于制备单磷酸连接的糖核苷酸,例如tmp-β-Gal和cmp-N-乙酰基神经氨酸以及四种唾液酸衍生物,它们的氨基官能团具有不同的修饰.在细菌多唾液酸转移酶催化的聚合反应中研究了cmp-唾液酸衍生物.
DOI:10.1002/cbic.201200471

海关参考信息

2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905399001-1,3-丙二醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-6319695-B1
优先权日:1991-10-15
标题:Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose
发明人：WONG CHI-HUEY; ICHIKAWA YOSHITAKA; SHEN GWO-JENN; LIU KUN-CHIN
权利人:SCRIPPS RES INSITUTE
摘要:This invention contemplates improved methods of enzymatic production of carbohydrates especially fucosylated carbohydrates. Improved syntheses of glycosyl 1- or 2-phosphates using both chemical and enzymatic means are also contemplated. The phosphorylated glycosides are then used to produce sugar nucleotides that are in turn used as donor sugars for glycosylation of acceptor carbohydrates. Especially preferred herein is the use of a disclosed method for fucosylation.

专利号:EP-0642526-B1
优先权日:1991-10-15
标题:Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of gdp-fucose

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主要参考文献

参考标题:Large‐scale Synthesis Of Per‐O‐acetylated Saccharides And Their Sequential Transformation To Glycosyl Bromides And Thioglycosides
作者:Li‐cheng Huang,Pi‐hui Liang,Ching‐yang Liu,Chun‐cheng Lin |发布日期:2006.6
摘要:This Work Describes A Large‐scale Synthesis Of Per‐o‐acetylated Mono‐ And Disaccharides Using A Stoichiometric Amount Of Acetic Anhydride In The Presence Of Liclo4 Under Solvent‐free Conditions. The Peracetylated Saccharides Underwent Subsequent Anomeric Bromination And Thioglycosidation In One‐pot To Yield Synthetically Valuable Building Blocks.