CAS: 83-55-6; 5-Aminonaphthalen-1-Ol

该化合物是一种氯化萘衍生物,具有氨基和羟基功能组,使其成为有机合成的多用途中间体,其双功能结构允许在组合反应,氮染色生产和制药应用中选择性反应,可允许有选择地反应,产生氮染,并使用药物.该化合物在极溶剂中表现出中等溶解性,便于其在水和有机反应系统中使用.在受控制条件下的稳定性确保合成工艺的可靠性能.5-Amino-1-naphthol因其在合成染料,色素和先进材料的合成中所发挥的作用而特别受到重视,其芳香脊和次成有助于预期的光学和电子特性.适当处理是由于对光和氧化的潜在敏感性.

结构式图片

相似化合物

5959-56-8 118-46-7 86-97-5

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上下游产品

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合成工艺路线路线简述

  • 合成目标产物 5-Amino-1-Naphthol 主要起始原料 5-Nitro-1-Naphthol
  • (文献来源)合成步骤主要原料 5-Nitro-1-Naphthol
4-Acetylamino-8-Amino-Naphthalene-1-Sulfonic Acid置于盐酸,Sodium Hydroxide,Sodium Disulfite体系中,化学反应生成 1-氨基-5-萘酚
参考文献:Bucherer; Uhlmann,Journal Fur Praktische Chemie (Leipzig 1954),1909,Vol. <2> 80,P. 238
标题:Bucherer; Uhlmann,Journal Fur Praktische Chemie (Leipzig 1954),1909,Vol. <2> 80,P. 238

海关参考信息

专利信息


专利号:US-7550510-B2
优先权日:2001-07-06
标 题 :Solid phase synthesis of arylretinamides
发明人:CURLEY JR ROBERT W; MERSHON SERENA M; BARNETT DEREK W; CLAGETT-DAME MARGARET; CHAPMAN JASON S
权利人:WISCONSIN ALUMNI RES FOUND
摘要:A solid phase synthetic method for preparing arylretinamides is provided. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a suspension comprising an activated chlorinating reagent; reacting retinoic acid with the activated chlorinating reagent to provide retinoyl chloride; adding pyridine and a select arylamine to the resulting mixture; and stirring the resulting mixture for a time and at a temperature sufficient for the select arylamine to react with the retinoyl chloride and provide the arylretinamide. Also provided, are select arylretinamides that can be prepared by the present method, and methods of using such arylretinamides to induce apoptosis in cancer cells.

专利号:US-5916899-A
优先权日:1996-10-18
标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人:KIELY JOHN S; GRIFFITH MICHAEL C
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.

专利号:US-2004102650-A1
优先权日:2001-07-06
标 题:Solid phase synthesis of arylretinamides

专利号:US-8653223-B2
优先权日:2008-04-16
标题:Transketalized compositions, synthesis, and applications
发明人:SELIFONOV SERGEY; GOETZ ADAM EDWARD; JING FENG
权利人:SELIFONOV SERGEY; GOETZ ADAM EDWARD; JING FENG; SEGETIS INC
摘要:Ketal compounds of the structure I n nand a method of preparation of the compound from polyols and oxocarboxylates, as well as uses thereof.

专利号:US-6417195-B1
优先权日:1999-02-22
标题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人:LEBL MICHAL
权利人:LION BIOSCIENCE AG
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.

专利号:US-5874443-A
优先权日:1995-10-19
标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人:KIELY JOHN S; GRIFFITH MICHAEL C
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.
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主要参考文献

[参考文献]: Dharam Paul Jindal, Et Al. Synthesis And Beta 1-, Beta 2-Adrenergic Receptor Binding Studies Of 4-Acylamino-Substituted Phenoxypropanolamine And 5-Acylamino-Substituted Naphthyloxypropanolamine Derivatives. Arzneimittelforschung. 2002;52(9):654-63.
[参考文献]: Ewa Rozycka-Sokolowska, Et Al. 5-Amino-1-Naphthol: Two-Dimensional Sheets Built Up From R(4)(4)(18) Rings Formed By O-H...N, N-H...O And Pi-Pi Interactions. Acta Crystallogr C. 2009 Nov;65(Pt 11):O565-8.
[参考文献]: Issey Osaka, Et Al. 5-Amino-1-Naphthol, A Novel 1,5-Naphthalene Derivative Matrix Suitable For Matrix-Assisted Laser Desorption/ionization In-Source Decay Of Phosphorylated Peptides. Rapid Commun Mass Spectrom. 2013 Jan 15;27(1):103-8.

合成参考文献


摘要:Compound: Poly(5-amino-1-naphthol)
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