专利号:US-7550510-B2 优先权日:2001-07-06 标 题 :Solid phase synthesis of arylretinamides 发明人:CURLEY JR ROBERT W; MERSHON SERENA M; BARNETT DEREK W; CLAGETT-DAME MARGARET; CHAPMAN JASON S 权利人:WISCONSIN ALUMNI RES FOUND 摘要:A solid phase synthetic method for preparing arylretinamides is provided. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a suspension comprising an activated chlorinating reagent; reacting retinoic acid with the activated chlorinating reagent to provide retinoyl chloride; adding pyridine and a select arylamine to the resulting mixture; and stirring the resulting mixture for a time and at a temperature sufficient for the select arylamine to react with the retinoyl chloride and provide the arylretinamide. Also provided, are select arylretinamides that can be prepared by the present method, and methods of using such arylretinamides to induce apoptosis in cancer cells.
专利号:US-5916899-A 优先权日:1996-10-18 标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries 发明人:KIELY JOHN S; GRIFFITH MICHAEL C 权利人:TREGA BIOSCIENCES INC 摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.
专利号:US-2004102650-A1 优先权日:2001-07-06 标 题:Solid phase synthesis of arylretinamides
专利号:US-8653223-B2 优先权日:2008-04-16 标题:Transketalized compositions, synthesis, and applications 发明人:SELIFONOV SERGEY; GOETZ ADAM EDWARD; JING FENG 权利人:SELIFONOV SERGEY; GOETZ ADAM EDWARD; JING FENG; SEGETIS INC 摘要:Ketal compounds of the structure I n nand a method of preparation of the compound from polyols and oxocarboxylates, as well as uses thereof.
专利号:US-6417195-B1 优先权日:1999-02-22 标题 :Isoquinoline derivatives and isoquinoline combinatorial libraries 发明人:LEBL MICHAL 权利人:LION BIOSCIENCE AG 摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.
专利号:US-5874443-A 优先权日:1995-10-19 标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries 发明人:KIELY JOHN S; GRIFFITH MICHAEL C 权利人:TREGA BIOSCIENCES INC 摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.
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