CAS: 79265-30-8; 2-(Trimethylsilyl)Thiazole

• 英文名称2-(Trimethylsilyl)Thiazole
• 中文名称2-(三甲基硅基)噻唑
• IUPAC名称2-(trimethylsilyl)thiazole
• 其它别名2-三甲基硅基噻唑
• CAS编号79265-30-8
• MFCD编号:MFCD00066274
• EINECS号:627-932-6
• 分子式:C6H11NSSi
• 分子量:157.31
• 产品CID: 1787074
• 产品分类有机原料→分子砌块→芳杂环类化合物→噻唑类化合物

• 相似结构搜索
• 产品信息参考
• InChIKey: VJCHUDDPWPQOLH-UHFFFAOYSA-N
• InChI=1S/C6H11NSSi/c1-9(2,3)6-7-4-5-8-6/h4-5H,1-3H3…
• 计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数1.0

物理性质

• 沸点174.7±0.0 °C at 760 mmHg
• 闪点57.2°C
• 密度1.0±0.1 g/cm3
• pKa:2.91±0.10(预测)
• PSA:12.89
• LogP:1.6883
• 折射率1.487
• 蒸汽压1.6±0.3 mmHg at 25°C
• 溶解性Thf: Very Soluble(Lit.)
• 敏感性1.远离氧化物。2.对空气和湿气相对比较稳定。
• 外观形态透明无色至微黄色液体
• 储存条件惰性气氛,2-8°C
• 产品应用该化合物用于化学阴离子当量;有效的烷氧甲醛,氨基甲酰胺和拨号剂量的单碳同质试剂. 它参与了甲醚同化,与电极的金属和反应,交叉相撞反应等的反应.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  易燃液体 类别3
  严重眼刺激 类别2A
• 警示词Warning(警告)
• 危险描述H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H226 |易燃液体和蒸气.
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
• 危险等级3
• UN编号1993
• 危险品标志Xi
• 包装等级III
• 安全声明23-24/25-26
• 危险类别码36/37/38
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 75-77-4 + 3034-53-5 = 79265-30-8
  反应条件:1.1 Reagents: Butyllithium; -78 °C1.2 Solvents: Diethyl Ether
  标题:N-Type Organic Field-Effect Transistors With High Electron Mobilities Based On Thiazole-Thiazolothiazole Conjugated Molecules
  作者:Mamada,Masashi; Nishida,Jun-Ichi; Kumaki,Daisuke; Tokito,Shizuo; Yamashita,Yoshiro
  参考文献:Chemistry Of Materials 日期:2007 卷标:19(22) 页码:5404-5409]
  
  75-77-4 + 3034-53-5 = 79265-30-8
  反应条件:1.1 Reagents: Butyllithium Solvents: Diethyl Ether,Hexane; -78 °C; 15 Min,-78 °C; 1 H,-78 °C1.2 1 H,-78 °C; 1 H,-78 °C1.3 Reagents: Potassium Carbonate Solvents: Water; 0 °C
  标题:Discovery Of The Orally Effective Thyrotropin-Releasing Hormone Mimetic: 1-{n-[(4S,5S)-(5-Methyl-2-Oxooxazolidine-4-Yl)Carbonyl]-3-(Thiazol-4-Yl)-L-Alanyl}-(2R)-2-Methylpyrrolidine Trihydrate (Rovatirelin Hydrate)
  作者:Kobayashi,Naotake; Sato,Norihito; Fujimura,Yuko; Kihara,Tsuyoshi; Sugita,Katsuji; Et Al
  参考文献:Acs Omega 日期:2018 卷标:3(10) 页码:13647-13666]
  
  75-77-4 + 3034-53-5 = 79265-30-8
  反应条件:1.1 Reagents: Butyllithium Solvents: Diethyl Ether1.2 -
  标题:Diastereoselective Homologation Of D-(R)-Glyceraldehyde Acetonide Using 2-(Trimethylsilyl)Thiazole: 2-O-Benzyl-3,4-Isopropylidene-D-Erythrose (1,3-Dioxolane-4-Acetaldehyde,2,2-Dimethyl-α-(Phenylmethoxy)-,[r-(R*,R*)]-)
  作者:Dondoni,Alessandro; Merino,Pedro
  参考文献:Organic Syntheses 日期:1995 卷标:72 页码:21-31]
  
  75-77-4 + 288-47-1 = 79265-30-8 [标题:Reaction Conditions
  标题:Product Class 17: Thiazoles
  作者:Kikelj,D.; Urleb,U.
  参考文献:Science Of Synthesis 日期:2002 卷标:11 页码:627-833]
  
  75-77-4 + 3034-53-5 = 79265-30-8
  反应条件:1.1 Catalysts: Butyllithium
  标题:Reactions Of Trimethylsilylthiazoles With Ketens: A New Route To Regioselective Functionalization Of The Thiazole Ring
  作者:Medici,Alessandro; Pedrini,Paola; Dondoni,Alessandro
  参考文献:Journal Of The Chemical Society 日期:1981 卷标:(13) 页码:655-6]
  
  75-77-4 + 3034-53-5 = 79265-30-8
  反应条件:1.1 Reagents: Butyllithium Solvents: Diethyl Ether; -78 °C
  标题:Synthesis Of 5-Arylthiazoles. Comparative Study Between Suzuki Cross-Coupling Reaction And Direct Arylation
  作者:Primas,Nicolas; Bouillon,Alexandre; Lancelot,Jean-Charles; El-Kashef,Hussein; Rault,Sylvain
  参考文献:Tetrahedron 日期:2009 卷标:65(29-30) 页码:5739-5746]
  
  75-77-4 + 3034-53-5 = 79265-30-8
  反应条件:1.1 Reagents: Butyllithium Solvents: Diethyl Ether1.2 -
  标题:Synthesis Of (Trimethylsilyl)Thiazoles And Reactions With Carbonyl Compounds. Selectivity Aspects And Synthetic Utility
  作者:Dondoni,Alessandro; Fantin,Giancarlo; Fogagnolo,Marco; Medici,Alessandro; Pedrini,Paola
  参考文献:Journal Of Organic Chemistry 日期:1988 卷标:53(8) 页码:1748-61]
  
  75-77-4 + 288-47-1 = 79265-30-8
  反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran; 10 Min,-78 °C; 1 H,-78 °C1.2 Solvents: Tetrahydrofuran; -78 °C; 1 H,-78 °C1.3 Reagents: Sodium Bicarbonate Solvents: Water; -78 °C
  标题:Efficient Access To 5-Substituted Thiazoles By A Novel Metallotropic Rearrangement
  作者:Zambon,Alfonso; Borsato,Giuseppe; Brussolo,Stefania; Frascella,Pietrogiulio; Lucchini,Vittorio
  参考文献:Tetrahedron Letters 日期:2008 卷标:49(1) 页码:66-69]
  
  75-77-4 + 3034-53-5 = 79265-30-8
  反应条件:1.1 Reagents: Butyllithium Solvents: Diethyl Ether; 30 Min,-78 °C; 30 Min,-78 °C1.2 Solvents: Diethyl Ether; -78 °C; 1 H,-78 °C; -78 °C -> Rt1.3 Reagents: Sodium Bicarbonate Solvents: Water; Rt
  标题:Design And Synthesis Of A Library Of Lead-Like 2,4-Bisheterocyclic Substituted Thiophenes As Selective Dyrk/clk Inhibitors
  作者:Schmitt,Christian; Kail,Dagmar; Mariano,Marica; Empting,Martin; Weber,Nadja; Et Al
  参考文献:Plos One 日期:2014 卷标:9(3)]
  
  75-77-4 + 3034-53-5 = 79265-30-8
  反应条件:1.1 Catalysts: Butyllithium
  标题:2-(Trimethylsilyl)Thiazole
  作者:Dondoni,Alessandro; Merino,Pedro
  参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001

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