CAS: 7782-24-3; (S)-2-Phenylpropanoic Acid

上下游产品

CAS号214492-02-1 (4R)-3-((2S)-2-... | CAS号93-53-8 2-苯基丙醛 | CAS号124-38-9 二氧化碳 | CAS号672-65-1 1-氯-1-苯乙烷 | CAS号492-37-5 2-苯基丙酸 | CAS号62784-66-1 二-1-萘甲醇 | CAS号492-38-6 2-苯基丙烯酸 | CAS号110282-71-8 Bis(phenanthren... | CAS号255711-93-4 (R)-but-1-ene-1... | CAS号292638-84-7 phenylene-ethylene | CAS号492-37-5 2-苯基丙酸 | CAS号2627-86-3 (S)-(-)-α-甲基苄胺 | CAS号7782-26-5 R-2-苯基丙酸 | CAS号13490-74-9 (S)-2-苯丙酰胺

2-苯基丙酸置于(R)-Binol-Sncl4,Lithium Diisopropyl Amide体系中,用 四氢呋喃,二氯甲烷,甲苯 作为反应溶剂,化学反应 3.5H,反应生成 S-2-苯基丙酸
参考文献:用路易斯酸辅助的手性布朗斯台德酸对甲硅烷基烯醇醚和乙烯酮二甲硅烷基缩醛进行对映选择性质子化:反应范围和机理见解
标题:用路易斯酸辅助的手性布朗斯台德酸对甲硅烷基烯醇醚和乙烯酮二甲硅烷基缩醛进行对映选择性质子化:反应范围和机理见解
摘要:对映选择性质子化是构建手性碳的有效方法.在这里,我们报告了使用路易斯酸辅助手性布朗斯台德酸(手性 Lba)的反应细节.四氯化锡与光学活性联萘酚((R)-或(S)-Binol)的1:1配位络合物可直接质子化各种甲硅烷基烯醇醚和乙烯酮二甲硅烷基缩醛,得到相应的α-芳基酮和α-芳基羧酸,分别具有高对映体过量(高达 98% Ee).在四氯化锡存在下,使用化学计量量的 2,6-二甲基苯酚和催化量的光学活性 Binol 的单甲醚也实现了对映选择性质子化的催化形式.这种质子化对于生产 α-卤代羰基化合物也很有效(高达 91% Ee).
DOI:10.1021/ja001164I

专利信息

专利号:US-10030003-B2
优先权日:2014-09-10
标 题:Synthesis of isoflavanes and intermediates thereof
发明人：BELIAEV NIKOLAI; SHAFRAN YURI
权利人:SYSTEM BIOLOGIE AG
摘要:Subject of the invention is a method for enantioselective production of an isoflavane from an isoflavone, comprising the steps: (a) selectively reducing the isoflavone, such that the 4-keto group of the isoflavone is converted to a 4-hydroxy group, and the 2,3-double bond of the isoflavone is converted to a 2,3-single bond, thereby obtaining a 4-hydroxy intermediate, and (b) reacting the 4-hydroxy intermediate with a chiral reagent, such that a chiral group is covalently attached to the C4-position of the 4-hydroxy intermediate, thereby obtaining a chiral intermediate. The invention also relates to intermediates of formulae (IV), (V), (VI) and (VII) obtainable in the inventive process.

专利号:US-11999741-B2
优先权日:2017-05-26
标 题:Process for the synthesis of 6-((3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-3-(tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one
发明人：SVENSTRUP NIELS; ZHANG JUN; SUN JIKUI; CHEN YUYIN; KONG JIANSHE; MA RUJIAN; ZHANG JUNHUA; QIN LIANG; XIAO HUANMING; SUN JINXU; MENG XIAO; SUN FENGLAI; ZHU JINGYANG
权利人:CARDURION PHARMACEUTICALS INC
摘要:The present disclosure relates to processes for preparing 64(3s,4s)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-3-(tetrahydropyran-4-yl-7h-imidazo[1,5-a]pyrazin-8-one.

专利号:US-2025019381-A1
优先权日:2017-05-26
标题 :PROCESS FOR THE SYNTHESIS OF 6-((3S,4S)-4-METHYL-1-(PYRIMIDIN-2-YLMETHYL)PYRROLIDIN-3-YL)-3-(TETRAHYDROPYRAN-4-YL-7H-IMIDAZO[1,5-a]PYRAZIN-8-ONE

专利号:EP-3008197-A2
优先权日:2013-06-13
标题 :Method for biocatalytic synthesis of substituted or unsubstituted phenylacetic acids and ketones having enzymes of microbial styrene degradation

专利号:US-2016186217-A1
优先权日:2013-06-13
标 题 :Method for biocatalytic synthesis of substituted or unsubstituted phenylacetic acids and ketones having enzymes of microbial styrene degradation

专利号:CA-2960437-A1
优先权日:2014-09-10
标 题 :Synthesis of isoflavanes and intermediates thereof