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专利信息

专利号:US-12263177-B2
优先权日:2019-02-07
标题:Biologically active ganoderma lucidum compounds and synthesis of anticancer derivatives; ergosterol peroxide probes for cellular localization
发明人：MARTINEZ-MONTEMAYOR MICHELLE M; RIVAS FATIMA
权利人:UNIV CENTRAL DEL CARIBE; ST JUDE CHILDRENS RES HOSPITAL INC
摘要:The bioactive compounds of Ganoderma lucidum extract (GLE) responsible for anticancer activity were elucidated using NMR, X-ray crystallography and analogue derivatization, as well as anti-cancer activity studies. Structures of the seven most abundant GLE compounds are disclosed. Their selective efficacy against triple negative (TNBC) and inflammatory breast cancers (IBC) and other human cancer cell types (solid and blood malignancies) was shown, confirming potential their as anticancer agents.

专利号:WO-2023175036-A1
优先权日:2022-03-16
标 题 :Process for synthesizing poly(spermine acrylamide) and/or poly(spermine acrylamide-co-n-alkylacrylamide) and their application
发明人：MERKEL OLIVIA; ZIMMERMANN CHRISTOPH; ADAMS FRIEDERIKE; BALDASSI DOMIZIA
权利人:UNIV MUENCHEN LUDWIG MAXIMILIANS
摘要:The present invention relates to a process for the synthesis of poly(spermine acrylamide) and/or poly(spermine acrylamide-co-N- alkylacrylamide), the process comprising the following steps: a) Reacting a mixture of N-acryloxysuccinimide with N-alkylacrylamide, and b) Obtaining poly(N-acryloxysuccinimde) polymers, poly(N- alkylacrylamide) polymers and/or copolymers with varying ratios of N- acryloxysuccinimide and N-alkylacrylamide, and c) Treating the obtained polymers and/or copolymers of step b) with at least 0.1 equivalent of tri-boc spermine per N-acryloxysuccinimide- repeating unit and obtaining poly(spermine acrylamide) and/or poly(spermine acrylamide-co-N-alkylacrylamide) polymers.

专利号:WO-2025006460-A9
优先权日:2023-06-30
标题:Systems and methods of sequencing polynucleotides with modified bases
发明人：LU BO; WEI WEI; GOH HUI KHENG KAREN; VIECELI JOHN SILVIO; TEO YIN NAH
权利人:ILLUMINA INC
摘要:Described are DNA sequencing systems and methods. Systems and methods for determining the nucleotide sequence of a polynucleotide may include determining the sequence of a polynucleotide with more than four types of bases by increasing the number of encoding states in sequencing by synthesis (SBS) systems. The systems and methods may expand the encoding space of current systems by discretizing the amplitude space in a channel into more than two states, and/or by adding additional channels.

专利号:US-2025281557-A1
优先权日:2024-03-08
标 题:Methods for cascade amplifications of therapeutic payloads (catp) & compositions for cancer immunotherapies and gene therapy
发明人：LI YINGZHONG; ZHANG LIBIN
权利人:SUNVAX MRNA THERAPEUTICS INC
摘要:The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncolytic defective virus compositions and methods of in vivo synthesis thereof. The composition includes a first nucleic acid construct encoding a self-amplifying mRNA (sa-mRNA) encoding at least one gene of interest (GOI) or a plurality of GOIs, a second nucleic acid construct encoding an mRNA encoding at least one virus structural protein, and at least one payload delivery system.

专利号:US-2025244333-A1
优先权日:2024-01-31
标 题:Cell viability compensation (cvc) beads for flow cytometry applications and methods of using the same
发明人：FAN WEI; SHI XIAOSHAN; MEHRPOUYAN MAJID; GURYEV OLEG LEONIDOVICH; JENNINGS TRAVIS LEON
权利人:BECTON DICKINSON CO
摘要:The present disclosure provides control compositions as well as methods of making and using the same. Aspects of the control compositions include a control particle characterized by: a core; an aminated polymer including an amine configured to react with an amine reactive dye; and a nucleic acid configured to bind to a DNA binding dye, wherein the aminated polymer and the nucleic acid are covalently associated with the core. Aspects of the invention further include methods of synthesizing the control particles of the compositions, the synthesis methods including: obtaining a core; and covalently associating a polymer including an amine and a nucleic acid with the core to produce a control particle. Also provided are methods for using the control compositions to perform compensation on cell viability data obtained using, e.g., flow cytometry, as well as kits for practicing the subject methods.

专利号:WO-2025006466-A1
优先权日:2023-06-30
标 题:Systems and methods of sequencing polynucleotides with four labeled nucleotides
发明人：KAGALWALLA ABDE ALI HUNAID; VIECELI JOHN SILVIO
权利人:ILLUMINA INC
摘要:The application relates to DNA sequencing systems and methods. Systems and methods for determining the nucleotide sequence of a polynucleotide may include introducing a fourth labeled nucleotide in a two-channel sequencing by synthesis system that allows for encoding space for a detecting a fifth labeled nucleotide or empty well detection.