CAS: 72300-69-7; (R)-Pyrrolidin-2-Ylmethanamine

相似化合物

119020-01-8 177911-87-4 259537-92-3

上下游产品

(R)-prolinamide Z-D-proline D-Prolin (2R)-2-carbamoyl-pyrrolidine-1-carboxylic acid benzyl ester (4aS,13aR)-8-bromo-10-[(phenylmethyl)oxy]-2,3,4a,5,13,13a-hexahydro-1H-pyrido[1,2-a]pyrrolo[1′,2′:3,4]imidazo[1,2-d]pyrazine-9,11-dione N-[((2R)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-2-pyrrolidinyl)methyl]-3,4-bis(methyloxy)benzenesulfonamide N-[((2R)-1-{[3,4-bis(methyloxy)phenyl]sulfonyl}-2-pyrrolidinyl)methyl]-3,4-bis(methyloxy)benzenesulfonamide

📜(R)-2-(氨甲基)-1-Boc-吡咯烷置于盐酸,水体系中,用 四氢呋喃,甲醇,二氯甲烷 作为反应溶剂,化学反应 1.0H,以100%的收率获得产物(R)-2-(氨甲基)吡咯烷
参考文献:Wo2006/116764
标题:Wo2006/116764

专利信息

专利号:US-5468876-A
优先权日:1986-05-22
标题:Intermediates for the stereoconservative synthesis of 1-substituted (S)-and (R)-2-aminomethylpyrrolidines
发明人：FEDERSEL HANS-JUEGEN; HOE THOMAS; RAEMSBY STEN I; STROEM PETER H E
权利人:ASTRA AB
摘要:Disclosed are (R)- and (S)-isomers of the compounds of the Formulas II and III with at least 95% optical purity ##STR1## wherein R 1 and R 2 are the same or different and represent a hydrogen atom, a lower alkyl, lower alkenyl or lower alkynyl group, a cycloalkyl group or a group (CH 2 ) m Ph, wherein m is 0-3 and Ph is a substituted or unsubstituted phenyl group. n These compounds are intermediates in the stereoconservative synthesis of 1-substituted (S)- and (R)-2-aminomethylpyrrolidines.

专利号:US-9365587-B2
优先权日:2008-12-11
标 题:Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates
发明人：YOSHIDA HIROSHI; TAODA YOSHIYUKI; JOHNS BRIAN ALVIN; KAWASUJI TAKASHI; NAGAMATSU DAIKI
权利人:SHIONOGI & CO; VIIV HEALTHCARE CO
摘要:The invention is a process for the preparation of a compound of the following formula (I): n nwherein R is —CHO, —CH(OH) 2 or —CH(OH)(OR 4 ); P 1 is H or a hydroxyl protecting group; P 3 is H or a carboxy protecting group; R 3 is H, halogen, hydroxy, optionally substituted lower alkyl, optionally substituted cycloalkyl, etc.; R x is H, halogen or R 2 —X—NR 1 —C(O)—; etc. as defined in the specification. The compounds are useful as intermediates in synthesizing compounds having HIV integrase inhibitory activity.

专利号:WO-2019012000-A1
优先权日:2017-07-12
标题:NEW SYNTHESIS OF INTERMEDIATES FOR THE PREPARATION OF ALPHA-TOCOPHEROL

专利号:WO-8707271-A1
优先权日:1986-05-22
标 题 :A stereoconservative synthesis of 1-substituted (s)- and (r)-2-aminomethylpyrrolidines and intermediates thereto

专利号:US-8754214-B2
优先权日:2008-12-11
标题 :Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates

专利号:FI-880265-A7
优先权日:1986-05-22
标题 :Efficient stereostructure preserving synthesis of 1-substituted (S)- and (R)-2-aminomethylpyrrolidines and their intermediates