CAS: 6609-64-9; 2-Chloro-1,3,2-Dioxaphospholane-2-Oxide

相似化合物

823-31-4 6711-47-3 2196-04-5

上下游产品

CAS号822-39-9 2-氯-1,3,2-二氧磷杂环戊烷 | CAS号107-21-1 乙二醇 | CAS号2196-04-5 2-methoxy-1,3,2... | CAS号6711-47-3 2-Hydroxy-1,3,2... | CAS号74389-68-7 1-O-十六烷基-2-乙酰基-... | CAS号74389-69-8 血小板活化因子(C18) | CAS号112989-02-3 rac-3-°Ctadecan... | CAS号16492-16-3 2-phenoxy-1,3,2... | CAS号146556-18-5 2-hexadecoxy-1,... | CAS号121234-89-7 2-phenylmethoxy... | CAS号922522-52-9 2-(2-methoxyeth... | CAS号554-68-7 三乙胺盐酸盐

乙二醇置于三氯氧磷体系中,用 苯 作为反应溶剂,化学反应 0.08H,反应生成 2-氯-2-氧-1,3,2-二氧磷杂环戊烷
参考文献:Interaction Between Zwitterionic Surfactants And Amphiphilic Drug: A Tensiometric Study
标题:Interaction Between Zwitterionic Surfactants And Amphiphilic Drug: A Tensiometric Study
摘要:物理化学性质,如带电表面活性剂(标记为n(-)-2-M+; N = 8,10,12和m = 12,14,16)及其与两性抗抑郁药阿米替林盐酸盐(amt)混合物的临界胶束浓度(cmc),表面过剩浓度(γmax),每个头基最小面积(amin)通过表面张力测量确定.cmc和理想cmc(cmc Id)值以及相互作用参数βm和βσ(使用rubingh和rosen模型计算)表明组分之间存在吸引相互作用.krafft温度测量也表明存在强烈的吸引相互作用.γmax(或amin)随着双子表面活性剂的添加而增加(或减少);这些值接近药物的值.这些值和胶束摩尔分数(x1M-从rubingh模型计算和x1Moto-从motomura模型计算)表明双子表面活性剂在混合胶束中的贡献更大,在气液界面的贡献较小(因为界面的摩尔分数值x1σ略小于x1M).胶束化的标准吉布斯能(δgmicº)和吸附(δgadº)以及混合的过剩能(δgexm)均为负值.所有这些结果表明混合系统的稳定性更高.uv吸收结果还表明混合胶束在几天内是稳定的.
DOI:10.1524/zpch.2012.0340

专利信息

专利号:US-9643915-B2
优先权日:2013-03-15
标题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-9708354-B2
优先权日:2013-03-15
标 题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-5756770-A
优先权日:1987-12-31
标题:Synthesis of stable, water-soluble chemiluminescent 1,2-dioxetanes and intermediates therefor
发明人：BRONSTEIN IRENA Y; EDWARDS BROOKS
权利人:TROPIX INC
摘要:A novel synthesis of 1,2-dioxetane phosphate alkali metal salts and novel intermediates employed in this synthesis are disclosed. A hydroxyaryl enol ether alkali metal salt having the formula: ##STR1## wherein T can be an unsubstituted or substituted adamant-2'-ylidene group, R 3 can be a methyl group, Y can be a phenyl group and M + can be a sodium cation, is reacted with a phosphorohalidate to give the corresponding enol ether ethylene phosphate, which is then reacted with an alkali metal cyanide to give the corresponding enol ether cyanoethyl phosphate diester alkali metal salt intermediate. Singlet oxygen addition to this enol ether cyanoethyl phosphate diester alkali metal salt intermediate to give the corresponding 1,2-dioxetane cyanoethyl phosphate diester alkali metal salt, followed by β-elimination of the cyanoethyl group using an alkali metal hydroxide or the like, gives the corresponding 1,2-dioxetane phosphate alkali metal salt.

专利号:EP-0629195-B1
优先权日:1992-03-05
标 题 :Synthesis of stable, water-soluble chemiluminescent 1,2-dioxetanes and intermediates therefor
发明人：BRONSTEIN IRENA Y; EDWARDS BROOKS
权利人:TROPIX INC
摘要:A novel synthesis of 1,2-dioxetane phosphate alkali metal salts and novel intermediates employed in this synthesis are disclosed. A hydroxyaryl enol ether alkali metal salt having formula (1), wherein T can be an unsubstituted or substituted adamant-2'-ylidene group, R<3> can be a methyl group, Y can be a phenyl group and M<+> can be a sodium cation, is reacted with a phosphorohalidate to give the corresponding enol ether ethylene phosphate, which is then reacted with an alkali metal cyanide to give the corresponding enol ether cyanoethyl phosphate diester alkali metal salt intermediate. Singlet oxygen addition to this enol ether cyanoethyl phosphate diester alkali metal salt intermediate to give the corresponding 1,2-dioxetane cyanoethyl phosphate diester alkali metal salt, followed by beta -elimination of the cyanoethyl group using an alkali metal hydroxide or the like, gives the corresponding 1,2-dioxetane phosphate alkali metal salt.

专利号:WO-9714703-A1
优先权日:1995-10-16
标 题:Synthesis of polymerisable phosphodiesters
发明人：DRIVER MICHAEL JOHN; RUSSEL JEREMY COLIN; BROWNE JUDITH ELIZABETH; SAMMES PETER G
权利人:BIOCOMPATIBLES LTD; DRIVER MICHAEL JOHN; RUSSEL JEREMY COLIN; BROWNE JUDITH ELIZABETH; SAMMES PETER G
摘要:A mono- or di-functional phosphoramidite phosphitylating agent is used to phosphitylate an ethylenically unsaturated alcohol. The product may be oxidised to form the corresponding phosphate ester which may be reacted in further steps to form phosphoryl choline derivatives. The process is of value in the synthesis of 2-(Methacryloyloxyethyl)-2'-(trimethylammoniumethyl)phosphate, inner salt. It has the advantage over prior art processes in that the starting materials and intermediates are more stable and consequently easier to handle.

专利号:US-6417380-B1
优先权日:1987-12-31
标 题 :Synthesis of 1,2-dioxetanes and intermediates therefor
发明人：BRONSTEIN IRENA Y; EDWARDS BROOKS
摘要:Compounds having the formula: n wherein T is a polycycloalkylidene group (e.g., adamant-2-ylidene); R is a C 1-20 alkyl, aralkyl or cycloalkyl group; and Y is a fluorescent chromophore (e.g., n m-phenylene), produced by reacting a compound having the formula: n with an R-ylating agent (e.g., R 2 SO 4 ) in the presence of an alkali metal alkoxide in a polar aprotic solvent. Also, compounds having the formula: n are produced by reacting a compound having the formula: n with n wherein X is an electronegative leaving group (e.g., a halogen anion such as chloride ion) in the presence of a Lewis base (e.g., a trialkyl-amine) dissolved in an aprotic organic solvent (e.g., benzene or toluene). Also, compounds having the formula n are produced by reacting a compound of the formula n with a tetra-O-acylated-O-hexopyranoside halide, then hydrolyzing off the protective acyl groups. The aforementioned compounds and procedures are useful in the synthesis of enzyme-cleavable 1,2-dioxetane ring systems that can serve as members of a binding pair employed, for example, in chemiluminescent immunoassays, DNA probe assays, and direct assays for an enzyme.