CAS: 607-71-6; 4-Methyl-2H-Chromen-2-One

上下游产品

CAS号141-97-9 乙酰乙酸乙酯 | CAS号108-95-2 苯酚 | CAS号201230-82-2 carbon monoxide | CAS号10277-93-7 2-Isopropenylphenol | CAS号536-74-3 苯乙炔 | CAS号878672-65-2 4-methyl-2-oxo-... | CAS号78822-89-6 phenyl tetrolate | CAS号623-43-8 巴豆酸甲酯 | CAS号15126-06-4 4-羟基-3-碘苯甲酸甲酯 | CAS号103027-92-5 4-methyl-6-nitr... | CAS号91-64-5 香豆素 | CAS号77902-78-4 tetrafluoro-l4-... | CAS号25624-32-2 4-methylchromen... | CAS号2963-66-8 2-(2-羟基苯基)-1H-苯并咪唑 | CAS号2555-28-4 7-甲氧基-4-甲基香豆素 | CAS号886-38-4 二苯基环丙烯酮 | CAS号3147-55-5 3,5-二溴-2-羟基苯甲酸 | CAS号90-33-5 4-甲基伞形酮 | CAS号2373-31-1 6-羟基-4-甲基香豆素

乙酸苯酯置于aluminum Oxide,沙林,Silica Gel体系中,279.85 °C,101.3 Kpa 条件下,反应生成 4-甲基香豆素
参考文献:苯酚与乙酸的酰化气相合成羟基苯乙酮
标题:苯酚与乙酸的酰化气相合成羟基苯乙酮
摘要:在sio 2-Al 2 O 3,Al-Mcm-41,Hy和zsm5沸石以及负载在mcm-41和碳上的钨磷酸(hpa)上,研究了苯酚与乙酸的酰化气相合成芳族酮的方法..在146 Gh / Mol的接触时间下,苯酚的初始转化率在12.5%(hy)和19.1%(hpa / Mcm-41)之间变化,对邻羟基苯乙酮(o-Hap)的初始选择性在37.1%(hpa)之间/ C)和69.1%(hy).在所有情况下,与对-异构体相比,明显倾向于形成o-Hap .沸石hy和zsm5,其中载有强布朗斯台德和路易斯酸位点,产生了有效ö-通过苯酚的直接c-酰化和由苯酚的o-酰化形成的乙酸苯酯中间体的酰化的-Hap.基于hpa的催化剂仅包含布朗斯台德酸位点,并且仅作为乙酸苯酯的副产物形成邻-Hap.zsm5的邻hap产量随投产时间保持恒定,但其他样品由于形成焦炭而急剧下降.考虑到避免了焦炭前体形成进入该沸石的微
DOI:10.1016/j.Jcat.2004.05.030

专利信息

专利号:US-5139940-A
优先权日:1989-10-26
标题 :Activation compounds and methods of synthesis of activation compounds
发明人：ISAACS STEPHEN T; CIMINO GEORGE D; METCHETTE KENNETH C; TESSMAN JOHN W
权利人:ISAACS STEPHEN T; CIMINO GOERGE D; METCHETTE KENNETH C; TESSMAN JOHN W
摘要:The invention is directed to isopsoralen compound compositions that contain a variety of substitutions which yet permit their binding to nucleic acid polymers. Reaction conditions that activate these bound isopsoralens results in covalent crosslinking to the nucleic acid polymers. The resultant complex is inhibited from being a template for the template-directed enzymatic synthesis of a complementary nucleic acid polymer. Beside the isopsoralens compositions, the invention includes their synthesis, the nucleic acid complex production and detection, and the above inhibitory method of use of the isopsoralens.

专利号:US-6451543-B1
优先权日:1998-08-31
标题:Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides
发明人：KOCHENDOERFER GERD G; HUNTER CHRISTIE L; KENT STEPHEN B H; BOTTI PAOLO
权利人:GRYPHON SCIENCES
摘要:The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polypeptide embedded within a lipid matrix via stepwise chemoselective chemical ligation of unprotected peptide segments, where at least one peptide segment is embedded in a lipid matrix. Any chemoselective reaction chemistry amenable for ligation of unprotected peptide segments can be employed. Suitable lipid matrices include liposomes, micelles, cell membrane patches and optically isotropic cubic lipidic phase matrices. Prefolded synthetic and semi-synthetic membrane polypeptides synthesized according to the methods and compositions of the invention also permit site-specific incorporation of one or more detectable moieties, such as a chromophore, which can be conveniently introduced during synthesis. The methods and compositions of the invention have multiple uses. For example, they can be used to assay ligand binding to membrane polypeptides and domains comprising a receptor, and thus are extremely useful for structure/function studies, drug screening/selection/design, and diagnostics and the like, including high-throughput applications. The methods and compositions of the invention are particularly suited for FRET analyses of previously inaccessible membrane polypeptides.

专利号:US-10005807-B2
优先权日:2013-04-12
标题 :Synthesis of sialylated/fucosylated human milk oligosaccharides
发明人：CHASSAGNE PIERRE; KHANZHIN NIKOLAY; HEDEROS MARKUS JONDELIUS; CHAMPION ELISE; MATWIEJUK MARTIN; DEKANY GYULA
权利人:GLYCOM AS
摘要:An achemo-enzymatic synthesis of oligosaccharides of formula 1 is presented wherein R is selected from —OH, —N 3 and —OR 6 wherein R 6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, —(CH 2) n —NH 2 and —(CH 2) n —N 3 wherein integer n is to 10, preferably 2 or 3, R is selected from sialyl moiety, —SO 3 H and —CH(R)—COOH wherein R is selected from H, alkyl and benzyl, R 2 is selected from H and fucosyl, R 3 is selected from H and sialyl, R 4 is selected from H and fucosyl, provided that at least one of R 3 and R 4 is H, and A is a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

专利号:WO-2014167537-A1
优先权日:2013-04-12
标题:Synthesis of sialylated/fucosylated oligosaccharides
发明人：KHANZHIN NIKOLAY; CHASSAGNE PIERRE; HEDEROS MARKUS; CHAMPION ELISE; MATWIEJUK MARTIN; DEKANY GYULA
权利人:GLYCOM AS
摘要:This invention relates to a chemo-enzymatic synthesis of oligosaccharidesof formula 1 wherein R is selected from -OH, -N 3 and -OR 6 wherein R 6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, -(CH 2 ) n -NH 2 and -(CH 2 ) n -N 3 wherein integer n is to 10, preferably 2 or 3, R 1 is selected from sialyl moiety, -SO 3 H and -CH(R 5 )-COOH wherein R 5 is selected from H, alkyl and benzyl, R 2 is selected from H and fucosyl, R 3 is selected from H and sialyl, R 4 is selected from H and fucosyl, provided that one but only one of R 3 and R 4 is H, and A is selected from a bond and a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

专利号:US-6303764-B1
优先权日:1998-09-24
标题:Synthesis of 4,7-dialkyl chromogenic glycosides of N-acetylneuraminic acids
发明人：SRIVASTAVA OM; SRIVASTAVA GEETA; DU MINGHUI; HINDSGAUL OLE; BUNDLE DAVID R; LIAV AVRAHAM
权利人:ZYMETX INC; HALIFEX FUND L P
摘要:The present invention provides an improved method of preparing a 4,7-di-O-alkyl chromogenic ketoside of N-acetylneuraminic acid (Neu5Ac) for use in detecting influenza virus types A and B. The ketosides are substrates that are selectively cleaved by a neuraminidase on influenza virus, but not be neuraminidases found on other viruses or on bacteria. The synthesis is efficient and provides large quantities of the ketoside for commercial development. The synthesis includes a step of alkylating the 4- and 7-hydroxyl groups of a protected alkyl ester alkyl ketoside derivative of Neu5Ac by a process that comprises contacting the derivative with a composition comprising an alkyl halide to form a 4,7-di-O-alkyl protected alkyl ester alkyl ketoside derivative of Neu5Ac. The synthesis alternatively includes protecting the 8- and 9-hydroxyl groups of an alkyl ester alkyl ketoside derivative of Neu5Ac by forming an 8,9-epoxide protected alkyl ester alkyl ketoside derivative of Neu5Ac.

专利号:US-2019078126-A1
优先权日:2017-09-08
标 题 :Polymerase-mediated, template-independent polynucleotide synthesis
发明人：BAIGA THOMAS; BURLEY MICHAEL ANDERSON; SMITH ALEXANDER
权利人:SIGMA ALDRICH CO LLC; MERCK PATENT GMBH
摘要:Methods for de novo synthesis of polynucleotides in which 3′-O-reversibly blocked nucleotides are attached to a solid support in the presence of an X family DNA polymerase and in the absence of a nucleic acid template.