CAS: 604-51-3; Deptropine

该化合物是一种化学化合物,被归类为抗胆碱剂,主要用于医疗领域,以缓解与各种条件,特别是与胃肠道有关的症状.复合功能是阻止乙酰胆碱的动作,乙酰胆碱是一种...

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    5-chlorodibenzosuberane 3-tropanol

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      专利号:US-5900227-A
      优先权日:1996-06-17
      标题 :Multicyclic nitrone spin trapping compositions
      发明人：JANZEN EDWARD G; SANKURATRI NAGARAJU
      权利人:OKLAHOMA MED RES FOUND
      摘要:Multicyclic nitrone spin trapping compounds capable of forming stable free radical spin adducts are provided as well as methods for their synthesis. The multicyclic nitrone spin trapping compounds can be reacted with a free radical, such as a hydroxy or hydroperoxy radical, in solution to form a spin adduct which is stable and readily detectable by electron paramagnetic resonance (EPR) spectroscopy. The multicyclic nitrone spin traps can be used to detect free radicals in a sample such as a biological system. In one embodiment, the spin trapping compound, 1,3,3-trimethyl-6-azabicyclo-[3.2.1]oct-6-ene-N-oxide ('TRAZON') is provided, as well as methods for the synthesis of TRAZON and of modified forms of TRAZON. TRAZON can react with a wide range of different free radicals in solution to form free radical spin adducts which are readily detectable by EPR.

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      1: Liang YC, Chang CC, Sheu MT, Lin SY, Chung CC, Teng CT, Suk FM. The Antihistamine Deptropine Induces Hepatoma Cell Death through Blocking Autophagosome-Lysosome Fusion. Cancers (Basel). 2020 Jun 18;12(6):1610. doi: 10.3390/cancers12061610.
      2: Qu C, Li Y, Li Y, Yu P, Li P, Donkers JM, van de Graaf SFJ, de Man RA, Peppelenbosch MP, Pan Q. FDA-drug screening identifies deptropine inhibiting hepatitis E virus involving the NF-κB-RIPK1-caspase axis. Antiviral Res. 2019 Oct;170:104588. doi: 10.1016/j.antiviral.2019.104588. Epub 2019 Aug 12. (1):22-3. French. 144(50):2409-11. Dutch. 40(11):885-9. doi: 10.1093/bja/40.11.885. 8(15):6717-6729. doi: 10.1002/cam4.2493. Epub 2019 Sep 10.
      7: Barber PV, Chatterjee SS, Scott R. A comparison of ipratropium bromide, deptropine citrate and placebo in asthma and chronic bronchitis. Br J Dis Chest. 1977 Apr;71(2):101-4. doi: 10.1016/0007-0971(77)90089-4.

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      摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
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