CAS: 5466-62-6; 4-Hydroxy-6-Oxo-1H-Pyridine-3-Carboxylic Acid

该化合物是硝酸的衍生物,其特点是在环的4和6个位置有2个氢氧(-OH)组,该化合物是白色的脱白晶体,在水和极有机溶剂中溶解,反映其因氢氧基组的具有的流体生殖性;它表现出酸性,典型的碳酸,并能够参与各种化学反应,包括酯化和氧化;氢基组的存在增强了氢联结的潜力,可影响氢联动性和其他分子的相互作用. 4,6-二氢氧辛基酸在各个领域都有意义,包括医药化学领域,可以作为生物活性化合物合成的前体,或作为协调的离子体化学的前体;其结构特征也可能促进其生物活动,使其成为药理学和生物化学研究的主体.

结构式图片

相似化合物

6975-44-6 79398-27-9 1256807-30-3

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

CAS号6975-44-6 4,6-二羟基烟酸乙酯 | CAS号24501-21-1 3-硝基吡啶-2,4-二胺 | CAS号89282-12-2 2,4-二羟基-3-硝基吡啶 | CAS号70593-57-6 4,6-二氯吡啶-3-酰胺 | CAS号52559-11-2 2,3,4-三氨基吡啶 | CAS号5975-12-2 2,4-二氯-3-硝基吡啶 | CAS号166526-03-0 4,6-二氯烟腈

合成工艺路线路线简述

    📜4,6-二羟基烟酸乙酯置于氢氧化钾体系中,化学反应生成 4,6-二羟基烟酸
    参考文献:Errera,Gazzetta Chimica Italiana,1898,Vol. 28 I,P. 489
    标题:Errera,Gazzetta Chimica Italiana,1898,Vol. 28 I,P. 489

    海关参考信息

    专利信息


    专利号:US-8188113-B2
    优先权日:2006-09-14
    标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
    发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
    权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
    摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals., NX#03055
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知