3-甲基吡唑置于sodium Dichromate,硫酸,硝酸体系中,化学反应生成 4-硝基吡唑-3-甲酸 参考文献:Nitropyrazoles 标题:Nitropyrazoles 摘要:A New Preparative Method For The Synthesis Of 3(5)-Amino-4-Nitropyrazole Starting From Accessible 3(5)-Methylpyrazole Has Been Elaborated. Nitration Of The Former Affords 3(5)-Nitramino-4-Nitropyrazole Or 1,4-Dinitro-3-Aminopyrazole,Depending On The Reaction Conditions. DOI:10.1007/bf00699004
专利号:US-9217012-B2 优先权日:2009-04-08 标题 :Inhibitors of protein tyrosine phosphatases 发明人:ZHANG ZHONG-YIN; ZHANG SHENG 权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP 摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.
专利号:US-4317823-A 优先权日:1979-08-03 标题 :Pyrazolobenzodiazepinones, their intermediates, their compositions and their use 发明人:RAINER GEORG 权利人:BYK GULDEN LOMBERG CHEM FAB 摘要:1-(Lower)alkyl-4-(substituted)aminoalkylcarbonyl-1,4,9,10-tetrahydropy razolo[4,3-b][1,5]benzodiazepin-10-ones are useful, e.g., to protect warm blooded animals against the formation of gastric ulcers. They are active ingredients in otherwise conventional medicament compositions administered enterally or parenterally in standard dosage forms. Their synthesis, their novel intermediates and their acid-addition salts are described.
[参考文献]: Jing Wei, Et Al. Molecular Docking Study Of A(3) Adenosine Receptor Antagonists And Pharmacophore-Based Drug Design. Neurochem Int. 2009 Dec;55(7):637-42.
合成参考文献
参考文献:10.1007/s11172-024-4254-2 摘要:Khoranyan TE, Gushchina PK, Suponitsky KY, Dalinger IL. N-Acetonylnitropyrazolecarboxylic acids in the selective synthesis of N-acetonyl-3-R-5-nitropyrazolyl-1,2,4-oxadiazoles. Russ Chem Bull. 2024 May;73(5):1362–73. doi: 10.1007/s11172-024-4254-2.