CAS: 53213-82-4; 3-Hexyl-2-(3-(3-Hexylbenzo[d]Oxazol-2(3H)-Ylidene)Prop-1-En-1-yl)Benzo[d]Oxazol-3-Ium Iodide

专利信息

专利号:US-9125942-B2
优先权日:2010-01-19
标题 :Paramagnetic metal-nanodiamond conjugates
发明人：MANUS LISA M; MASTARONE DANIEL J; HO DEAN; MEADE THOMAS J
权利人:MANUS LISA M; MASTARONE DANIEL J; HO DEAN; MEADE THOMAS J; UNIV NORTHWESTERN
摘要:The present invention provides compositions and methods for the synthesis of conjugates of paramagnetic metal ions and nanodiamonds, and uses thereof. In particular, the present invention provides synthesis of paramagnetic metal-nanodiamond conjugates and methods using such compositions as molecular imaging probes.

专利号:US-7320993-B1
优先权日:1997-12-17
标题 :Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents
发明人：BIEDERMANN ELFI; HASMANN MAX; LOESER ROLAND; RATTEL BENNO; REITER FRIEDEMANN; SCHEIN BARBARA; SEIBEL KLAUS; VOGT KLAUS; WOSIKOWSKI KATJA; SCHEMAINDA ISABEL
权利人:ASTELLAS DEUTSCHLAND GMBH
摘要:The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid group, methods for the synthesis of these compounds, medicaments containing these and their production as well as their therapeutic use, especially as cytostatic agents and immunosuppressive agents, for example in the treatment or prevention of various types of tumors and control of immune reactions such as autoimmune diseases.

专利号:WO-2012016973-A1
优先权日:2010-08-02
标 题:Invention related to contact allergens
发明人：SCHMIDT MARC; GOEBELER MATTHIAS; BADRINARAYANAN RAGHAVAN
权利人:TRANSMIT GMBH; SCHMIDT MARC; GOEBELER MATTHIAS; BADRINARAYANAN RAGHAVAN
摘要:The problem of the underlying invention is to foresee a new method and a new class of substances to treat and or reduce hypersensivity (CHS) with mammals, especially humans to nickel, especially Ni 2+ . Surprisingly it was found, that the site-specific h TLR4 inhibition as potential strategy for therapeutic intervention without affecting vital immune responses. Here we demonstrate that Ni 2+ induces an inflammatory response via direct activation of human Toll-like receptor 4 (hTLR4). Remarkably, Ni 2+ induces TLR4 activation is species-specific since mouse TLR4 (mTLR4) is incapable to generate this response. Studies with mutant TLR4 proteins revealed a requirement of the non-conserved histidines 456 and 458 of h TLR4 for activation by Ni 2+ but not by the natural ligand LPS. Accordingly, transgenic h TLR4 expression in Tlr4 -deficient mice allowed efficient sensitization to Ni 2+ and elicitation of CHS. Allergies to nickel (Ni 2+) are the most frequent cause of contact hypersensitivity (CHS) in industrialized countries. Both a T lymphocyte-specific signal and a proinflammatory signal are required for efficient CHS development. Here we demonstrate that Ni 2+ induces an inflammatory response via direct activation of human Toll-like receptor 4 (hTLR4). Remarkably, Ni 2+ induced TLR4 activation is species-specific since mouse TLR4 (m TLR4) is incapable to generate this response. Studies with mutant TLR4 proteins revealed a requirement of the non-conserved histidines 456 and 458 of h TLR4 for activation by Ni2+ but not by the natural ligand LPS. Accordingly, transgenic h TLR4 expression in Tlr4 -deficient mice allowed efficient sensitization to Ni 2+ and elicitation of CHS. Our data implicate site-specific h TLR4 inhibition as potential strategy for therapeutic intervention without affecting vital immune responses. Furthermore it is shown that hypersensitivity-related inflammatory response via direct activation of human Toll-like receptor 4 (h TLR4) is not only induced by nickel but also by cobalt (Co 2+ ). Moreover, the invention surprisingly describes synthesis of truncated h TLR4 molecules (s-h TLR4) missing the transmembrane domain and the C-terminal part of the protein that are applicable in a method for identification of substances to treat and or reduce hypersensitivity (CHS) or sepsis with mammals by inhibition of h TLR4 activation.

专利号:WO-2020054824-A1
优先权日:2018-09-13
标 题 :Method for measuring activity of mitochondrial respiratory complex
发明人：OHTA YOSHIHIRO; KASHIWAGI HIROKO; GOTO YUICHI
权利人:LUCA SCIENCE INC
摘要:Provided is a method for detecting the activity of mitochondria in a single cell or a single mitochondrial respiratory chain complex. A method for measuring the activity of, for example, mitochondrial respiratory chain complex V, said method comprising: contacting mitochondria with at least one electron donor for a respiratory chain complex selected from the group consisting of respiratory chain complexes I, III and IV; then contacting the mitochondria with an inhibitor of the adenosine triphosphate (ATP) synthesis activity of complex V; and measuring the membrane potential of the mitochondria before and after the contact with the inhibitor, wherein the change in the membrane potential before and after the contact with the inhibitor represents the activity of complex V.

专利号:US-2012215154-A1
优先权日:2011-02-22
标题:Synthesis of 2-(4-aminophenyl) benzothiazole derivatives and use thereof

专利号:US-8592603-B2
优先权日:2011-02-22
标 题 :Synthesis of 2-(4-aminophenyl) benzothiazole derivatives and use thereof