CAS: 4966-90-9; 4-Hydroxy-6-Methyl-3-Nitropyridin-2(1H)-One

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947144-26-5 125604-19-5 163803-34-7

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4-羟基-6-甲基-2-吡喃酮置于ammonium Hydroxide,硝酸,Sodium Nitrite体系中,用 溶剂黄146 作为反应溶剂,化学反应 6.5H,反应生成 4-羟基-6-甲基-3-硝基-2-吡啶醇
参考文献:4-叠氮基-3-硝基吡啶热环化成呋喃烷†
标题:4-叠氮基-3-硝基吡啶热环化成呋喃烷†
摘要:在硝化和氯化后从4-羟基-2-吡啶酮1和8中获得的4-氯-3-硝基-2-吡啶3和10与叠氮化钠一起得到4-叠氮基3-硝基吡啶4和11,在热解为呋喃烷6和12.用三苯基膦将呋喃喃6脱氧,得到呋喃山7.通过差示扫描量热法(dsc)研究了叠氮化物4的热分解条件和6至7的脱氧反应.
DOI:10.1002/jhet.5570370537

专利信息

专利号:EP-0609960-B1
优先权日:1989-09-15
标 题 :New N-heteroarylamide derivatives as inhibitors of acyl coenzyme A: cholestrol acyl transferase
发明人：MCCARTHY PETER A; HAMANAKA ERNEST S; WALKER FREDERICK J; CHANG GEORGE; TRUONG THIEN
权利人:PFIZER
摘要:Compounds of the formula the pharmaceutically acceptable salts thereof, wherein Q and R<1> are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.

专利号:US-5656634-A
优先权日:1991-03-21
标题 :N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
发明人：CHANG GEORGE; HAMANAKA ERNEST S; MCCARTHY PETER A; TRUONG THIEN V; WALKER FREDERICK J
权利人:PFIZER
摘要:Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R 1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.

专利号:US-5596001-A
优先权日:1993-10-25
标题 :4-aryl-3-(heteroarylureido)quinoline derivatves
发明人：HAMANAKA ERNEST S
权利人:PFIZER
摘要:Compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , m, X and Q are as defined below, and novel intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and natiatherosclerosis agents.