CAS: 3978-86-7; 11-(1-Methylpiperidin-4-Ylidene)-6,11-Dihydro-5H-Benzo[5,6]Cyclohepta[1,2-B]Pyridine Dimaleate

该化合物是一种主要用于治疗过敏条件的抗口炎,被归类为第一代抗口炎,这意味着它能够跨越血脑屏障,并可能引发镇静反应,该物质是一种由亚扎塔丁和雄性酸形成的盐,可增强它的溶性与稳定性.阿扎塔丁本身是抗异丙胺H1受体的一种抗口炎,从而缓解与过敏有关的症状,如喷鼻,痒痒和鼻涕.除其抗口炎特性外,阿扎塔丁还可能表现出抗胆碱性效应,这可促进其治疗特征,但也会导致副作用,如干嘴和尿液保留等.该化合物通常通过口服口服和多种配方获得.与许多药物一样,必须考虑与其他药物的潜在互动,以及特定人群(如孕妇或哺乳人员)的抗药性.

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    专利信息


    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

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    1: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. Azatadine. 2021 Sep 20. 55 Suppl
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    合成参考文献


    摘要:Medical Journal of Australia., 141(449), 1984
    摘要:Agents and Actions, A Swiss Journal of Pharmacology., 4(264), 1974 []
    摘要:Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports., 1(173), 1975
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