CAS: 35273-90-6; Chloromethyl Propyl Carbonate

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propan-1-ol carbon°Chloridic acid, chloromethyl ester

合成工艺路线路线简述

    📜丙醇,氯甲酸氯甲酯置于吡啶体系中,用 二氯甲烷 用作溶剂,以93%的收率获得氯甲基丙基碳酸酯
    参考文献:克服烷氧基羰基氧基甲基(aocom)卤化物与酚类偶联反应中的空间效应:Aocom酚类前药的有效合成
    标题:克服烷氧基羰基氧基甲基(aocom)卤化物与酚类偶联反应中的空间效应:Aocom酚类前药的有效合成
    摘要:立体位阻是aocom卤化物与酚类偶联反应的关键因素.立体上不受阻碍的烷氧基有利于酰化苯酚的形成.在相转移条件下,无论空间位阻如何,烷基化苯酚都是有利的.
    Doi:10.1016/j.Tetlet.2006.10.160

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    专利信息


    专利号:US-9907796-B2
    优先权日:2012-10-04
    标题:Methods of treating tumoral diseases, or bacterial or viral infections
    发明人：DEOKAR RHUSHIKESH CHANDRABHAN; DUGAR SUNDEEP; MAHAJAN DINESH; WERNER MILTON HENRY
    权利人:DEOKAR RHUSHIKESH CHANDRABHAN; DUGAR SUNDEEP; MAHAJAN DINESH; WERNER MILTON HENRY; INHIBIKASE THERAPEUTICS INC
    摘要:Novel compounds and their synthesis are described. Methods for using these compounds in the prevention or treatment of cancer, a bacterial infection or a viral infection in a subject are also described.

    专利号:US-9359376-B2
    优先权日:2011-04-08
    标题:Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds
    发明人：DUGAR SUNDEEP; MAHAJAN DINESH; HOLLINGER FRANK PETER
    权利人:DUGAR SUNDEEP; MAHAJAN DINESH; HOLLINGER FRANK PETER; SPHAERA PHARMA PTE LTD
    摘要:The present invention relates to the synthesis and application of novel chiral/achiral substituted methyl formyl reagents to modify pharmaceutical agents and/or biologically active substances to modify the physicochemical, biological and/or pharmacokinetic properties of the resulting compounds from the unmodified original agent.

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    合成参考文献

    合成方法参考DOI号:10.1016/j.tetlet.2006.10.160
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