CAS: 3235-67-4; 1-Piperidineacetic Acid

相似化合物

3040-44-6 3010-03-5 23853-10-3

上下游产品

piperidine chloroacetic acid piperidin-1-yl-acetic acid ethyl ester bromoacetic acidN-Piperidinessigsaeure-butylester dibenzyl piperidinoglycyl-L-prolyl-L-glutamate N-(1-piperidinomethylcarbonyl)-L-phenylalanine N-(4-Acetyl-phenyl)-2-piperidin-1-yl-acetamide

📜1-哌啶乙酸乙酯置于potassium Hydroxide,盐酸体系中,用 水 用作溶剂,化学反应生成1-哌啶基乙酸
参考文献:开发了一系列作为g-四链体配体的双三唑†
标题:开发了一系列作为g-四链体配体的双三唑†
摘要:端粒酶(一种保护染色体末端的特殊复合物)的维护是由端粒酶复合物提供的,端粒酶是80%以上的癌细胞激活但在大多数正常细胞中却不存在的关键因素.靶向端粒维持机制可能会阻止多种癌症类型的肿瘤生长.染色体的端粒末端由富含鸟嘌呤的dna的非编码重复序列组成.这些富含g的末端可以折叠成称为g-四链体的结构.通过称为g4配体的小结合分子稳定g-四链体可以阻止端粒酶维持癌细胞中端粒的完整性.G-四链体也可以存在于基因组的其他部分,尤其是在癌基因的启动子序列中,并且也是有趣的药物靶标.这里,我们描述了一系列新的新型双三唑的开发,这些双三唑旨在稳定地将g-四链体结构作为g4配体来稳定.Fret分析显示两种化合物是中等有效的g4结合剂,对由hsp90A启动子序列形成的四链体具有特定的亲和力,并且对g-四链体dna具有非常好的选择性与双链dna.但是,Cd光谱法未能提供有关由于其与配体之一相互作用而导致的人类端粒g
Doi:10.1039/c7Ra07257K

专利信息

专利号:EP-0454867-B1
优先权日:1989-11-17
标题:A METHOD FOR THE SYNTHESIS OF $g(a), $g(b)-UNSATURATED KETONES
发明人：TSUKASHIMA KEIICHI TAKAOKA PLA; NAKAJIMA MASASHI TAKAOKA PLANT; FUJIMARU MASAYOSHI TAKAOKA PLA; SUZUKI KENJI TAKAOKA PLANT
权利人:NIPPON SODA CO
摘要:The present invention relates to a method for the synthesis of alpha , beta -unsaturated ketones which comprises, in the method for the synthesis of alpha , beta -unsaturated ketones represented by general formula (I) (where R<1> is an aliphatic group with a side chain at the 1 position, an alicyclic group, a substituted alicyclic group, a heterocyclic group, a substituted heterocyclic group, a phenyl group or a substituted phenyl group), reacting aldehydes represented by general formula (II): R<1>CHO (where R<1> is as defined above) with alkali metal salt of acetoacetic acid represented by general formula (III) (where M<+> is an alkali metal ion), in the presence as a catalyst of 3-azabicyclo[3,2,2] nonane, a cyclic secondary amine represented by general formula (1) (where n is 3 or more and up to 5, m is 1 or more and up to 10, R<2> is an alkyl group having 1 to 10 carbon atoms and of straight chain or with side chains, an alkyl group substituted by alicyclic groups or phenyl groups, an alicyclic group which may be substituted by lower alkyl groups, or a phenyl group which may be substituted by lower alkyl groups, and an R<2> substitution position is at a carbon atom other than the two adjacent to N), a cyclic secondary amine represented by general formula (2) (where l is 1 or more and up to 6, a ring with N is a 6-membered, 7-membered or 8-membered ring, the two neighbors of N are methylene, R<3> is a lower alkyl group, its substitution position is at a carbon atom other than the two adjacent to N, and (a) is an alicyclic group or a phenyl group), or a secondary amine represented by general formula (3): CH3NHCH2R<4> (where R<4> is an aliphatic group having 5 to 17 carbon atoms and of straight chain or with side chains, an alicyclic group which may be substituted by lower alkyl groups, a phenyl group which may be substituted by lower alkyl groups, or an alkyl group substituted by phenyl groups), in a mixture solvent of water and water-insoluble organic solvent, while keeping the pH constant with mineral acid, and by adjusting the amount of water.

专利号:US-5484949-A
优先权日:1993-01-29
标题:Method for the synthesis of α β-unsaturated ketones
发明人：TSUKASHIMA KEIICHI; NAKAJIMA MASASHI; FUJIMARU MASAYOSHI; SUZUKI KENJI
权利人:NIPPON SODA CO
摘要:The present invention relates to a method for the synthesis of alpha , beta -unsaturated ketones which comprises, in the method for the synthesis of alpha , beta -unsaturated ketones represented by general formula reacting aldehydes represented by general formula R1CHO (where R1 is as defined above) with alkali metal salt of acetoacetic acid represented by general formula sence as a catalyst of 3-azabicyclo[3,2,2]nonane, a cyclic secondary amine represented by general formula (1) (1) a cyclic secondary amine represented by general formula (2) (2) (where, l is 1 or more and up to 6, a ring with N is a 6-membered, 7-membered or 8-membered ring, the two neighbors of N are methylene, R3 is a lower alkyl group, its substitution position is at a carbon atom other than two those adjacent to N, and is an alicyclic group or a phenol group), or a secondary amine represented by general formula (3) CH3NHCH2R4(3) in a mixuture solvent of water and water-insoluble organic solvent, while keeping the pH constant with mineral acid, and by adjusting an amount of water.

专利号:US-4355184-A
优先权日:1980-05-02
标题:Synthesis of α, β-unsaturated-ketones
发明人：KAKU TSUTOMU; KATSUURA KIYOSHI; SAWAKI MIKIO
权利人:NIPPON SODA CO
摘要:alpha , beta -unsaturated-ketones are synthesized by reacting with an aldehyde and an alkali metal salt of acetoacetic acid in the presence of an aliphatic secondary amine in the mixture of heterogeneous solvents producing an oil layer and a water layer.

专利号:US-6140505-A
优先权日:1995-03-10
标 题:Synthesis of benzo fused heterocyclic sulfonyl chlorides

专利号:US-4026918-A
优先权日:1973-09-26
标 题:D-homosteroids
发明人：FURST ANDOR; MULLER MARCEL; ALIG LEO; KELLER PETER; KERB ULRICH; WIECHERT RUDOLF; KIESLICH KLAUS; PETZOLDT KARL
权利人:FURST ANDOR; MULLER MARCEL; ALIG L; KELLER PETER; KERB ULRICH; WIECHERT RUDOLF; KIESLICH KLAUS; PETZOLDT KARL
摘要:Novel D-homosteroids of the formula ##STR1## are disclosed. The novel D-homosteroids exhibit anti-inflammatory activity and are useful intermediates for the synthesis of anti-inflammatory D-homosteroids.

专利号:EP-0454867-A1
优先权日:1989-11-17
标 题:METHOD FOR SYNTHESIS OF KETONES -g (a), -g (b) -UNSATURATED.