CAS: 29110-74-5; 3-Chloro-1H-Indazole
该化合物是一种杂交有机化合物,其特点是在三处用氯原子取代了异氮核心,该结构是制药和农用化学合成的多用途中间体,特别是在开发生物活性分子方面,其氯替代会增强回旋性,通过交叉或核生殖替代反应促进进一步的功能化;复合物在标准处理条件下具有稳定性,适合多种合成应用;研究人员价值3-Chloro-1H-indazole,因其在建造基于异氮的松鼠方面所起的作用,由于其潜在的治疗特性,在药用化学中非常普遍;通常供应高纯度,以确保实验工作流程的一贯性.
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;;;; - InChIKey: QPHAGNNWDZSKJH-UHFFFAOYSA-N
- InChI=1S/C7H5ClN2/c8-7-5-3-1-2-4-6(5)9-10-7/h1-4H,(H,9,10)
- 计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数0.0
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CAS号2596-89-6 3H-Indazol-3-im... | CAS号271-44-3 吲唑 | CAS号7647-01-0 盐酸 | CAS号33906-30-8 2-carboxyphenyl... | CAS号7364-25-2 3-吲唑啉酮 | CAS号10025-87-3 三氯氧磷 | CAS号36760-19-7 5-溴-3-氯吲唑 | CAS号36760-20-0 3,5-二氯-1H-吲唑 | CAS号271-44-3 吲唑 | CAS号131633-88-0 3-(哌嗪-1-基)-1H-吲唑合成工艺路线路线简述
📜吲唑置于ammonium Persulfate,N-氯代丁二酰亚胺,氧气,次甲基绿体系中,用 乙腈 用作溶剂,化学反应 24.0H,以69%的收率获得3-氯-吲唑
参考文献:有机染料的可见光光催化活化n-氯代琥珀酰亚胺氯化芳烃和杂芳烃
标题:有机染料的可见光光催化活化n-氯代琥珀酰亚胺氯化芳烃和杂芳烃
摘要:使用n-氯代琥珀酰亚胺(ncs)在可见光激活的条件下,以中等到极好的收率氯化多种芳烃和杂芳烃.对已知的有机染料光催化剂的筛选导致鉴定出亚甲基绿是与ncs一起使用的最有效的催化剂.根据其中描述的机理研究,推测该反应通过亚甲基绿在可见光光氧化还原途径下通过ncs的单电子氧化来进行.Ncs的光氧化作用放大了ncs氯原子的亲电性,从而提高了其作为氯化试剂与芳香族底物的反应性.
Doi:10.1016/j.Tet.2019.130498
海关参考信息
- 2902200000-苯
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专利信息
专利号:US-2024360125-A9
优先权日:2021-02-22
标 题 :2-substituted bicyclo[1.1.1]pentanes
发明人：MACMILLAN DAVID W; GARRY OLIVIA L; LIANG YUFAN; HEILMANN MICHAEL
权利人:UNIV PRINCETON
摘要:Provided herein are 2-substituted bicyclo[1.1.1]pentane (BCP) compounds, as well as methods of making the 2-substituted BCP compounds and methods of derivatizing the 2-substituted BCP compounds, particularly at the 2-position. The 2-substituted BCP compounds described herein are useful building blocks in the synthesis of a variety of products, including pharmaceuticals, polymers, liquid crystals, monolayers and supramolecular structures.
专利号:US-8536164-B2
优先权日:2010-12-20
标 题:Fused pyridine compounds as casein kinase inhibitors
发明人：BUTLER TODD W; CHANDRASEKARAN RAMALAKSHMI Y; MENTE SCOT R; SUBRAMANYAM CHAKRAPANI; WAGER TRAVIS T
权利人:BUTLER TODD W; CHANDRASEKARAN RAMALAKSHMI Y; MENTE SCOT R; SUBRAMANYAM CHAKRAPANI; WAGER TRAVIS T; PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: n nand pharmaceutically acceptable salts thereof, wherein X, Y, A, R 4 , n, and R 7 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
专利号:WO-2024193328-A1
优先权日:2023-03-20
标题 :Indazole substituted podophyllotoxin derivative, preparation method therefor, and use thereof
发明人：TANG YAJIE; ZHAO WEI; TANG YUNZHI
权利人:TANG YAJIE
摘要:An indazole nitrogen-substituted podophyllotoxin derivative represented by formula (V), a synthesis method therefor, and a use thereof. Different substituents, such as methyl, ethyl, propyl, benzyl, a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, etc., are respectively introduced into the 1 and 3 positions of indazole podophyllotoxin to obtain a compound represented by formula (V) having significantly improved antitumor activity.
专利号:CN-112573978-B
优先权日:2019-09-30
标题 :A kind of efficient halogenation synthesis method of aryl halide
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📌 第三方产品分析报告
主要参考文献
参考标题:The Asymmetric Synthesis Of Amines Via Nickel-Catalyzed Enantioconvergent Substitution Reactions作者:Ze-Peng Yang,Dylan J. Freas,Gregory C. Fu |发布日期:2021.2.24
摘要:Dialkyl Carbinamines Do Not Provide General Access To Amines Wherein The Two Alkyl Groups Are Of Similar Size (E.G., Ch2R Versus Ch2R1). Herein, We Report Two Mild Methods For The Catalytic Enantioconvergent Synthesis Of Protected Dialkyl Carbinamines, Both Of Which Use A Chiral Nickel Catalyst To Couple An Alkylzinc Reagent (1.1-1.2 Equiv) With A Racemic Partner, Specifically, An α-Phthalimido Alkyl Chloride
合成参考文献
摘要:Stadlbauer, W., Science of Synthesis, (2002) 12, 301.
摘要:Stadlbauer, W., Science of Synthesis, (2002) 12, 247.
摘要:Stadlbauer, W., Science of Synthesis, (2002) 12, 272.
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