CAS: 2456-81-7; 4-Pyrrolidinopyridine

相似化合物

722550-01-8 1352318-60-5 1447958-19-1

上下游产品

CAS号123-75-1 四氢吡咯 | CAS号7379-35-3 4-氯吡啶盐酸盐 | CAS号626-64-2 4-羟基吡啶 | CAS号337913-25-4 diphosphorus pe... | CAS号121409-81-2 methyl 4-oxo-4-... | CAS号626-61-9 4-氯吡啶 | CAS号100-48-1 4-氰基吡啶 | CAS号27248-04-0 trimethyl(pyrid... | CAS号15097-49-1 1-(三甲基甲硅烷基)吡咯烷 | CAS号504-24-5 4-氨基吡啶 | CAS号257937-23-8 3-bromo-4-(pyrr... | CAS号874758-84-6 2-氯-4-吡咯烷吡啶

N-Pyridin-4-Yl-Succinamic Acid Methyl Ester; Hydrochloride置于dimethyl Sulfide Borane体系中,用 四氢呋喃 用作溶剂,化学反应 9.0H,以58%的收率获得4-吡咯烷基吡啶
参考文献:Borane-Methyl Sulfide Reductive Cyclization Of ω-Ester Alkylamides: A Convenient Synthesis Ofn-Substituted Cyclic Amines
标题:Borane-Methyl Sulfide Reductive Cyclization Of ω-Ester Alkylamides: A Convenient Synthesis Ofn-Substituted Cyclic Amines
摘要:硼烷-硫化甲基(bms)还原各种n-取代的琥珀酰胺和戊二酰胺酯,可以高产率地得到相应的n-取代吡咯烷和哌啶.这一转化过程中,由于胺氮周围的空间阻碍限制,以及通过不完全反应和/或合成后续的bms还原检测到的假定中间体,表明环化作用和酰胺还原成功地与酯还原竞争,从而得到了n-取代的环化胺.
Doi:10.1055/s-1988-27777

专利信息

专利号:US-2006264608-A1
优先权日:2001-08-03
标题 :Bi-directional synthesis of oligoguanidine transport agents
发明人：WENDER PAUL A; VANDEUSEN CHRISTOPHER L; PATTABIRAMAN KANAKA; PELKEY ERIN T; JESSOP THEODORE C
权利人:WENDER PAUL A; VANDEUSEN CHRISTOPHER L; PATTABIRAMAN KANAKA; PELKEY ERIN T; JESSOP THEODORE C
摘要:Synthesis routes that can be adapted to large scale synthesis of oligoguanidine compounds such as oligoarginine compounds are described which use a perguanidinylation step to convert a group of ω-amino groups to the corresponding guanidinyl groups. These compounds find utility as transport agents. Modified oligoguanidine compounds are also described.

专利号:US-7067698-B2
优先权日:2001-08-03
标 题 :Bi-directional synthesis of oligoguanidine transport agents
发明人：WENDER PAUL A; VANDEUSEN CHRISTOPHER L; PATTABIRAMAN KANAKA; PELKEY ERIN T; JESSOP THEODORE C
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Synthesis routes that can be adapted to large scale synthesis of oligoguanidine compounds such as oligoarginine compounds are described which use a perguanidinylation step to convert a group of ω-amino groups to the corresponding guanidinyl groups. These compounds find utility as transport agents. Modified oligoguanidine compounds are also described.

专利号:US-6951932-B2
优先权日:2001-10-25
标 题:Synthesis of 2-aralkoxyadenosines and 2-alkoxyadenosines
发明人：MOORMAN ALLAN R
权利人:KING PHARMACEUTICALS RES & DEV
摘要:The invention provides new methods for synthesis of 2-aralkyloxyadenosines and 2-alkoxyadenosines. The invention is particularly useful for synthesis of 2-[2-(4-chlorophenyl)ethoxy]adenosine. Preferred methods of the invention include activating a guanosine compound followed by hydrolysis; alkylating the hydrolyzed compound with subsequent animation to provide a 2-aralkyloxyadenosine or a 2-alkoxyadenosine compound.

专利号:US-5554725-A
优先权日:1994-09-14
标题:Synthesis of dolastatin 15
发明人：PETTIT GEORGE R
权利人:UNIV ARIZONA
摘要:The present invention relates to the synthesis of natural (-)- dolastatin and the elucidation of the absolute configuration of this important sea hare constituent. A segment synthetic strategy was utilized for obtaining the Dolabella auricularia (Indian Ocean sea hare) depsipeptide dolastatin 15. Reaction of protected (S)-Hiva-(S)-Phe (2c) with isopropenyl chloroformate followed by Meldrum's ester, cyclization (2c→3a) of the product in toluene and finally methylation afforded the key (S)-dolapyrrolidine (Dpy) derivative (3b). Condensation of tripeptide (8) with the three unit Dpy segment (5b) followed by deprotection and coupling (diethyl phosphorocyanidate) led to dolastatin 15 in 11% overall yield. The powerful and selective activity of dolastatin 15 against the U.S. National Cancer Institute's panel of human cell lines is reported.

专利号:US-5656662-A
优先权日:1990-01-12
标 题:Synthesis of optically pure 4-alkenyl- or 4-alkanyl-2-hydroxytetronic acids
发明人：MANTRI PADMAJA; WITIAK DONALD T
权利人:UNIV OHIO STATE RES FOUND
摘要:The present invention relates to a method for synthesis of optically pure 4-alkenyl or 4-alkanyl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase, thus making them useful in the treatment of coronary artery diseases, especially atherosclerosis, and additionally, as inhibitors of various inflammatory cytokines, making them useful in the treatment of both acute and chronic inflammation, as well in the treatment of cachexia, rheumatoid arthritis, multiple sclerosis, Crohn's disease and ulcerative colitis. The invention further relates to pharmaceutical compositions of the instant compounds.

专利号:EP-1575929-B1
优先权日:2002-12-19
标 题 :The method for production of semi-finished products useful in synthesis of paclitaxel
发明人：KOLESINSKA BEATA; KAMINSKI J ZBIGNIEW; KAMINSKA E JANINA
权利人:AGROPHARM S A
摘要:The method for production of the semi-finished products useful in synthesis of Paclitaxel with the generalized formula (2), characterized in that phenyl isoserine derivatives, or mixtures of their epimerides with various configurations on the carbon 2' or their salts, are treated with triazine type condensing agent, possible in the presence of tertiary amine, in medium of anhydrous organic solvent, and the triazine esters produced are treated with Baccatin III, in medium of anhydrous organic solvent, possible in the presence of a catalyst.