专利号:US-5908944-A 优先权日:1991-09-27 标题 :Methylation or ethylation agent and process for 1,4-addition of a methyl or ethyl group to an α, β-unsaturated keto compound 发明人:WESTERMANN JUERGEN; NICKISCH KLAUS 权利人:SCHERING AG 摘要:This invention describes a new methylation or ethylation agent containing trimethyl aluminum or dimethyl zinc or triethyl aluminum as methyl or ethyl source, which additionally contains catalytic amounts of one or more copper(I) and/or copper(II) compounds as well as a process for the 1,4-addition of a methyl or ethyl group to an α,β-unsaturated or an α,β-double unsaturated ketone or an α,β-unsaturated aldehyde using the agent according to the invention. n By using only catalytic amounts of copper and a CKW (chlorinatedhydrocarbon)-free reaction medium, the new methylation/ethylation agent/process is distinguished by its environmental compatibility and it is, for example, suitable for the production of initial products for the synthesis of biologically effective compounds.
专利号:US-2025281509-A1 优先权日:2021-04-26 标 题 :Sequential hormone therapy to improve survival and enhance response to immune therapy in men with prostate cancer 发明人:DENMEADE SAMUEL R; ISAACS JOHN T; ANTONARAKIS EMMANUEL S; KACHHAP SUSHANT; MARKOWSKI MARK CHRISTOPHER 权利人:UNIV JOHNS HOPKINS 摘要:Disclosed are methods for treating men with castrate resistant prostate cancer with a sufficient dose of testosterone to achieve supraphysiologic serum levels of testosterone in sequence with androgen ablative treatment or androgen synthesis inhibitors for one or more cycles until evidence of radiographic progression, at which point the subject will receive immune checkpoint blockade therapy.
参考标题:Methylation Or Ethylation Agent And Process For 1,4-Addition Of A Methyl 摘要:This Invention Describes A New Methylation Or Ethylation Agent Containing Trimethyl Aluminum Or Dimethyl Zinc Or Triethyl Aluminum As Methyl Or Ethyl Source, Which Additionally Contains Catalytic Amounts Of One Or More Copper(I) And/or Copper(II) Compounds As Well As A Process For The 1,4-Addition Of A Methyl Or Ethyl Group To An .Alpha.,.Beta.-Unsaturated Or An .Alpha.,.Beta.-Double Unsaturated Ketone Or An .Alpha.,.Beta.-Unsaturated Aldehyde Using The Agent According To The Invention. By Using Only Catalytic Amounts Of Copper And A Ckw (Chlorinatedhydrocarbon)-Free Reaction Medium, The New Methylation/ethylation Agent/process Is Distinguished By Its Environmental Compatibility And It Is, For Example, Suitable For The Production Of Initial Products For The Synthesis Of Biologically Effective Compounds.
合成参考文献
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198