CAS: 2227-29-4; Chlorodiisopropylsilane

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7751-38-4 13154-24-0 18395-90-9

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CAS号75-29-6 2-氯丙烷 | CAS号920-39-8 异丙基溴化镁 | CAS号1068-55-9 异丙基氯化镁 | CAS号18027-99-1 phenyl-di(propa... | CAS号18043-71-5 1,1,3,3-四异丙基二硅氧烷 | CAS号261717-41-3 (E)-HEPTENYLDII... | CAS号85272-30-6 二异丙基硅基双(三氟甲烷磺酸盐) | CAS号7751-38-4 二异丙基二氯硅烷 | CAS号1461-22-9 三丁基氯化锡 | CAS号356056-16-1 diisopropyl-(1h... | CAS号356056-13-8 二异丙基(3,3,4,4,5,... | CAS号356056-14-9 二异丙基(3,3,4,4,5,... | CAS号326891-18-3 pent-3-ynoxy-di...

异丙基溴化镁置于三氯硅烷体系中,用 乙醚 用作溶剂,化学反应 18.0H,反应生成二异丙基氯代硅烷
参考文献:不对称催化.通过烯烃的对映选择性催化分子内氢化硅烷化生产手性二醇
标题:不对称催化.通过烯烃的对映选择性催化分子内氢化硅烷化生产手性二醇
摘要:铑 (I) 手性二膦配合物有效且快速地催化衍生自烯丙醇的甲硅烷基醚的分子内氢化硅烷化.测定了各种甲硅烷基和烯烃取代基的分子内硅氢化的效率和速率.尽管发现末端烷基烯烃取代基会延迟催化作用,但发现这些催化剂可以耐受多种甲硅烷基取代基.发现末端芳基烯烃取代基有效且以合理的速率进行氢化硅烷化
Doi:10.1021/ja00032A028

专利信息

专利号:US-9783549-B2
优先权日:2013-11-04
标题:Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E; LEE JAEMOON
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.

专利号:US-2004014168-A1
优先权日:1998-06-11
标题:Reagents and methods for library synthesis and screening
发明人：SCHREIBER STUART L; BLACKWELL HELEN E; PEREZ FERNANDEZ LUCY; TALLARICO JOHN A
权利人:HUGHES HOWARD MED INST
摘要:The invention provides novel solid supports for the synthesis of compound libraries. The solid supports have the physical capacity to deliver at least 50 nmol of compound and are functionalized with a silicon-containing linker. In one embodiment of the invention the solid support comprises a bead having a diameter of between approximately 400 and 600 μm functionalized with a silicon-containing linker. According to certain embodiments of the invention the bead is a polystyrene bead. According to certain embodiments of the invention the linker is a diisopropylalkyl-substituted silyl ether. The invention further provides grafted polymeric supports such as lanterns functionalized with a silicon-containing linker. n The invention provides methods for screening in which compounds are synthesized on solid supports in a quantity so that a single solid support such as a bead provides a stock solution sufficient to perform hundreds or thousands of biological or chemical assays. The methods include decoding the sequence of chemical reactions used to synthesize the compound by identifying tags incorporated into the compound during synthesis.

专利号:US-2004077674-A1
优先权日:2002-03-01
标题:Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs
发明人：CURRAN DENNIS P; PARNIAK MICHAEL A; GABARDA ANA; ZHANG WEI; LUO ZHIYONG; CHEN CHRISTINE HIU-TUNG
摘要:A compound having the following structure: n n n wherein Z is —CHOR 1 R 2 or —C(O)R 2 ; R 1 is H, an alkyl group, an aryl group, —OC(O)OR a , wherein R a is an alkyl group, —C(O)R b wherein R b is an alkyl group, an aryl group, an alkoxy group, an amino group, an alkylamino group, a dialkylamino group, an aryl amino group, a diarylamino group, an arylalkyl amino group, a protecting group or a fluorous tag; R 2 is an alkyl group, an aryl group or an arylalkyl group; R 3 is H, an alkyl group, hydroxyalkyl group or an aryl group; R 4 —R 8 are independently the same or different and are hydrogen, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, an alkoxy group, an aryloxy group, an acyloxy group, a haloalkyl group, a perfluoroalkyl group, fluorine, chlorine, bromine, a haloalkyloxy group, a carbamoyloxy group, a hydroxy group, a nitro group, a cyano group, a cyanoalkyl group, an azido group, an azidoalkyl group, a formyl group, a hydrazino group, a hydrazinoalkyl group, a hydroxyalkyl group, an alkoxyalkyl group, —NR 1 R m , wherein R 1 and R m are independently hydrogen, an alkyl group, an aryl group, an arylalkyl group, or —C(O)R b , an aminoalkyl group, an alkylaminoalkyl group, a dialkylaminoalkyl group, an aryl aminoalkyl group, a diarylaminoalkyl group, an arylalkyl aminoalkyl group, —OC(O)OR a , wherein R a is an alkyl group, —C(O)R b , —SR c , S(O)R c or S(O 2 )R c wherein R c is hydrogen, —C(O)R b , an alkyl group, or an aryl group, (CH 2 ) n SiR d R e R f wherein n is an integer within the range of 0 through 10 and R d , R e and R f are independently a C 1-10 alkyl group, a C 2-10 alkenyl group, a C 2-10 alkynyl group, an aryl group, a haloalkyl group, a cyanoalkyl group, an azidoalkyl group, a hydrazinoalkyl group, a hydroxyalkyl group, an alkoxyalkyl group, an aminoalkyl group, an alkylaminoalkyl group, a dialkylaminoalkyl group, an aryl aminoalkyl group, a diarylaminoalkyl group, an arylalkyl aminoalkyl group. Alternatively R 4 and R 5 , R 5 and R 6 ; R 6 and R 7 ; or R 7 and R 8 can form together a chain of 3 or four groups selected from CH, CH 2 , O, S, N, NH, N-alkyl or N-aryl. Provided that, at least one of R 5 —R 7 is not H, a lower alkyl group, fluorine, a cyano group, a hydroxyl group, hydroxyalkyl group, an alkoxy group, an aminoalkyl group, an alkylaminoalkyl group, a dialkylaminoalkyl group, an amino group, an alkylamino group, a dialkylamino group, a carbamoyloxy group, a formyl group or —C(O)R x wherein R x is an alkyl group.

专利号:US-11691883-B2
优先权日:2018-09-10
标题:Synthesis of trichlorosilane from tetrachlorosilane and hydridosilanes
发明人：AUNER NORBERT; STURM ALEXANDER G
权利人:MOMENTIVE PERFORMANCE MAT INC
摘要:The invention relates to a process for the preparation of trichlorosilane (HSiCl3) which comprises the reaction of tetrachlorosilane (SiCU) with hydridosilanes in the presence of a catalyst.

专利号:US-6444268-B2
优先权日:1998-09-01
标题 :Functionalization of substrate surfaces with silane mixtures
发明人：LEFKOWITZ STEVEN M; FULCRAND GERALDINE; DELLINGER DOUGLAS J; HOTZ CHARLES Z
权利人:AGILENT TECHNOLOGIES INC
摘要:Low surface energy functionalized surfaces on solid supports are provided by treating a solid support having hydrophilic moieties on its surface with a derivatizing composition containing a mixture of silanes. A first silane provides the desired reduction in surface energy, while the second silane enables functionalization with molecular moieties of interest, such as small molecules, initial monomers to be used in the solid phase synthesis of oligomers, or intact oligomers. Molecular moieties of interest may be attached through cleavable sites. Derivatizing compositions for carrying out the surface functionalization process are provided as well.

专利号:US-8779179-B2
优先权日:2010-05-28
标 题:Synthesis of silyl acetylenes
发明人：CLOUGH ROBERT S; ANTHONY JOHN E; PAYNE MARCIA M
权利人:CLOUGH ROBERT S; ANTHONY JOHN E; PAYNE MARCIA M; 3M INNOVATIVE PROPERTIES CO
摘要:The present disclosure provides a method of preparing silylethynyl compounds in which two of the hydrocarbyl groups bonded to the silicon exclusive of the ethynyl group, are the same and one is different, that may be used in preparing novel silylethynyl functionalized acene semiconductor chromophores.