CAS: 2163-80-6; Msma

专利信息

专利号:EP-1611083-B1
优先权日:2003-03-25
标 题:Synthesis of 2-chloromethyl-6-methylbenzoic acid esters
发明人：MAIER CLAUS-JUERGEN; METZENTHIN TOBIAS; GRAESER JOACHIM; BICKER RICHARD; MANERO JAVIER
权利人:SANOFI AVENTIS DEUTSCHLAND
摘要:The invention relates to a method for producing compounds of formula (I) wherein R represents H, optionally halogen-substituted alkyl, cycloalkyl or aryl, alkyl-aryl or heteroaryl, and at least one CH2 group can be replaced by O in alkyl and cycloalkyl. Said compounds of formula (I) are valuable intermediates in the synthesis of PPAR agonists.

专利号:EP-0909792-B1
优先权日:1997-10-15
标 题:Storage-stable composition for the synthesis of polyurethanes
发明人：BAUMANN EDWIN; HAEBERLE KARL DR; HORN PETER DR; TREULING ULRICH DR; SCHWAEBISCH HANS
权利人:BASF AG
摘要:Polyurethane synthesis composition using a polymeric emulsifier having a backbone consisting of a copolymer of 4-12C unsaturated dicarboxylic acid or anhydrides and 2-40C olefins, with polyoxyalkylene side chains derived from 2-20C oxiranes. A polyurethane (PU) synthesis composition containing, as emulsifier, a polymer (T) with (at least) a copolymer backbone (TR) derived from 4-12 carbon(C) unsaturated dicarboxylic acid(s) and/or their anhydrides (TR1) and 2-40 C olefin(s) (TR2), and having polyalkylene oxide side chain (TP) derived from 2-20 C oxirane(s) (TP1), together with at least two compounds (a) comprising at least two reactive hydrogen atoms, at least one of which is insoluble. Independent claims are also included for: (a) a process for the production of synthesis composition by contacting the components in presence of a polymer; (b) a PU synthesis composition obtained; (c) a polyurethane obtained by bringing the synthesis composition into contact with a polyisocyanate; and (d) moldings, fibers, coatings, paint, sheets and a foam made from the PU compositions.

专利号:EP-1474119-B1
优先权日:2002-02-15
标题:Use of extracts containing phytoestrogen selectively modulating estrogen-receptor-beta
发明人：WUTTKE WOLFGANG; JARRY HUBERTUS; CHRISTOFFEL VOLKER; SPENGLER BARBARA; POPP MICHAEL
权利人:BIONORICA AG
摘要:The present invention relates to the use of phytoestrogen-containing extracts that selectively modulate estrogen receptor beta (ER-beta) without producing any uterotropic effect, for the treatment of clinical situations and pathophysiological conditions that are selected from the group consisting of: Obesity and thereby to possibly influence the metabolic syndrome, particularly hypertension, asterosclerosis, cardiac infarct, hyperandrogenemia; Menopausal continence disorders; Menopausal heat surges associated with hyperstimulation of the hypothalamic gonadotropin releasing hormone pulse generator; steroid hormonal synthesis disorder, particularly that of progesterone synthesis of the human corpus luteum, resulting in luteal insuffeciency; Alzheimer's disease associated with elevated expression of estrogen receptor beta in hippocampal neurons.

专利号:WO-2011147453-A1
优先权日:2010-05-26
标 题 :Enzymatic synthesis of nootkatone
发明人：ZORN HOLGER; FRAATZ MARCO ALEXANDER; RIEMER STEPHANIE JOHANNA LUISE; TAKENBERG MEIKE; KRINGS ULRICH; BERGER RALF GUENTER; MARX STEFAN; ZELENA KATERYNA
权利人:N ZYME BIOTEC GMBH; ZORN HOLGER; FRAATZ MARCO ALEXANDER; RIEMER STEPHANIE JOHANNA LUISE; TAKENBERG MEIKE; KRINGS ULRICH; BERGER RALF GUENTER; MARX STEFAN; ZELENA KATERYNA
摘要:The invention relates to oxygenases from Pleurotus sapidus for the biocatalytic oxidation of valencene to form nootkatone (terpenes).

专利号:EP-1181395-B1
优先权日:1999-06-07
标题 :Method for the synthesis of dna fragments
发明人：SCHATZ OCTAVIAN
权利人:SLONING BIOTECHNOLOGY GMBH
摘要:The invention relates to a method that can be carried out in parallel and automated for the production of any nucleic acid, comprising the following steps: a) coupling an oligonucleotide to a solid matrix; b) adding an additional oligonucleotide; c) performing ligation of the oligonucleotide from steps a) and b) in an orientation; d) removing excess reactants and enzymes from the reaction preparation; e) effecting cleavage of the ligation product from step c) with a restriction system that cleaves outside the recognition sequence, whereby cleavage is effected in the shortened or lengthened oligonucleotide from step a) or in the oligonucleotide from step b); f) separating the reaction mixture from the lengthened or shortened oligonucleotide from step a); g) repeating at least one steps b) to f); h) performing successive sequence-independent linkage of the fragments obtained after executing steps a) to g) until the desired product is obtained.

专利号:WO-2009117985-A1
优先权日:2008-06-12
标题 :Pirinixic acid derivatives as prostglandin e2 synthesis inhibitors for treating inflammatory diseases
发明人：WERZ OLIVER; KOEBERLE ANDREAS; SCHUBERT-ZSILAVECZ MANFRED; POPESCU LAURA; SYHA YVONNE
权利人:MEDEON PHARMACEUTICALS GMBH; UNIV TUEBINGEN; WERZ OLIVER; KOEBERLE ANDREAS; SCHUBERT-ZSILAVECZ MANFRED; POPESCU LAURA; SYHA YVONNE
摘要:The invention relates to pirinixic acid derivatives, especially a-substituted pirinixic acids and pirinixic acid esters, and the structural derivatives thereof with the following structural formula. The pirinixic acid derivatives inhibit the PGE2 synthesis, especially that of the mPGES-1. The invention also relates to the use of said pirinixic acid derivatives for producing a medicament for treating prostaglandin E2-mediated diseases, especially inflammatory diseases, painful and feverish conditions, cardiovascular events and cancerous diseases associated with an increased inducible microsomal prostaglandin E2 synthesis-1 (mPGES-1) activity or increased prostaglandin E2 synthesis.