CAS: 207557-35-5; (S)-1-(2-Chloroacetyl)Pyrrolidine-2-Carbonitrile

相似化合物

207557-35-5 565452-98-4 274901-37-0

上下游产品

(S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide L-prolinamide L-proline L-prolineL-proline (S)-1-{2-[(5-cyanopyridin-2-yl)amino]ethyl-aminoacetyl}-2-cyano-pyrrolidine vildagliptin

L-谷氨酸5乙脂置于钾硼氢,四磷十氧化物,氯甲酸乙酯,三乙胺体系中,用 四氢呋喃,二氯甲烷,水 用作溶剂,化学反应 9.0H,反应生成(2S)-N-氯乙酰基-2-氰基四氢吡咯
参考文献:一种维格列汀的合成方法
标题:一种维格列汀的合成方法
摘要:本发明公开了一种维格列汀的合成方法,通过将l‑谷氨酸和乙醇进行酯化反应,制得l‑谷氨酸‑γ‑乙酯,将l‑谷氨酸‑γ‑乙酯在钾硼氢的作用下还原制得l‑脯氨酸,将l‑脯氨酸和氯甲酸乙酯混合反应得到酸酐,酸酐进一步与胺反应得到酰胺,酰胺在五氧化二磷的作用下进行脱水制得中间体1,将中间体1与氯乙酰氯进行取代反应制得中间体2,中间体2与3‑氨基‑1‑金刚烷醇进一步反应制得维格列汀,该方法制备维格列汀的过程中出现的杂质较少,且制备出的维格列汀产率高,且与现有工艺相比,工艺更加简单,大大降低了维格列汀的制备成本.

专利信息

专利号:US-2008300251-A1
优先权日:2005-09-05
标 题 :Derivatives of 3-Azabicyclo[3.1.0] Hexane as Dipeptidyl Peptidase-IV Inhibitors
发明人：SATTIGERI JITENDRA A; ANDAPPAN MURUGAIAH M S; KISHORE KAUSHAL; SETHI SACHIN; KANDALKAR SACHIN RAMESH; PAL CHANCHAL KUMAR; MAHAJAN DIPAK C; AHMED SHAHADAT; PARKALE SANTHOSH SADASHIV; SRINIVASAN T; SHARMA LALIMA; BANSAL VINAY S; CHUGH ANITA; DAVIS JOSEPH ALEXANAND
权利人:SATTIGERI JITENDRA A; ANDAPPAN MURUGAIAH M S; KISHORE KAUSHAL; SETHI SACHIN; KANDALKAR SACHIN RAMESH; PAL CHANCHAL KUMAR; MAHAJAN DIPAK C; AHMED SHAHADAT; PARKALE SANTHOSH SADASHIV; SRINIVASAN T; SHARMA LALIMA; BANSAL VINAY S; CHUGH ANITA; DAVIS JOSEPH ALEXANAND
摘要:The present invention relates to novel 3-azabicyclo[3.1.0]hexane derivatives as dipeptidyl peptidase-IV inhibitors and the processes for the synthesis of the said compounds. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating diabetes, especially type 2 diabetes, as well as prediabetes, diabetic dyslipidemia, metabolic acidosis, ketosis, satiety disorders, and obesity. These inhibitors can also be used to treat conditions manifested by a variety of metabolic, neurological, anti-inflammatory, and autoimmune disorders like inflammatory disease, multiple sclerosis, rheumatoid arthritis; viral, cancer and gastrointestinal disorders. The compounds of this invention can also be used for treatment of infertility arising due to polycystic ovary syndrome.

专利号:US-9150511-B2
优先权日:2011-05-24
标题 :Process for preparing saxagliptin and its novel intermediates useful in the synthesis thereof
发明人：KOVI RAVISHANKER; RAPOLE KESHAVRAO; NAIK ASHISH; KANNAPAN JAYARAMAN; MADALA MURALIKRISHNA; THAKOR SANJAY
权利人:APICORE US LLC
摘要:Methods of making saxagliptin, pharmaceutically acceptable salts and hydrates thereof and intermediates thereof.

专利号:WO-2011012322-A9
优先权日:2009-07-31
标题:Synthesis and use of vildagliptin for the preparation of pharmaceutical dosage forms

专利号:WO-2011012322-A2
优先权日:2009-07-31
标 题:Synthesis and use of vildagliptin for the preparation of pharmaceutical dosage forms

专利号:CN-118724782-A
优先权日:2024-08-07
标题:Vildagliptin Synthesis method of intermediate

专利号:EP-2459531-A2
优先权日:2009-07-31
标 题 :Synthesis and use of vildagliptin for the preparation of pharmaceutical dosage forms