📜2,4,4-三甲基-2-戊烯 反应生成三甲基戊醇 参考文献:Organoboranes. V. The Thermal Cyclization Of Dialkylboranes. A Convenient Synthesis Of 2,4,4-Trimethyl-1,5-Pentanediol And Related 1,5-Diols1 标题:Organoboranes. V. The Thermal Cyclization Of Dialkylboranes. A Convenient Synthesis Of 2,4,4-Trimethyl-1,5-Pentanediol And Related 1,5-Diols1 摘要: Doi:10.1021/ja00959A022
专利号:US-6909010-B2 优先权日:2001-04-11 标题:Facile synthesis of symmetric esters of alkylenebisphosphonic acids 发明人:HERLINGER ALBERT W; STEPINSKI DOMINIQUE C 权利人:UNIV LOYOLA CHICAGO 摘要:A facile synthesis of symmetric esters of C 1 -C 10 alkylenebisphopsphonic acids is disclosed in which a C 1 -C 10 alkylenebis(phosphonic dichloride) is reacted with an alcohol in the presence of a catalytic amount of 1H-tetrazole and a base in an aprotic solvent to form a first reaction mixture. The first reaction mixture is maintained for a time period sufficient to form a C 1 -C 10 alkylenebis(chloro ester phosphonate) that is reacted under basic conditions with an excess of a hydroxylated compound to form a second reaction mixture that is itself maintained for a time period sufficient to form a C 1 -C 10 alkylenebis(ester phosphonate) partial ester, homoleptic tetraester or mixed tetraester. The material so formed can be recovered or used as is.
专利号:US-11718596-B2 优先权日:2014-03-19 标题 :Amyloid targeting agents and methods of using the same 发明人:YANG JERRY; THEODORAKIS EMMANUEL A; SARRAF STELLA 权利人:UNIV CALIFORNIA; AMYDIS INC 摘要:Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.
专利号:US-5637757-A 优先权日:1995-04-11 标 题 :One-pot synthesis of ring-brominated benzoate compounds 发明人:HILL JOHN E; FAVSTRITSKY NICOLAI A; MAMUZIC RASTKO I; BHATTACHARYA BHABATOSH 权利人:GREAT LAKES CHEMICAL CORP 摘要:A method of preparing tetrabromobenzoate compounds from tetrabromophthalic anhydride by reacting tetrabromophthalic anhydride with alcohol in the presence of a decarboxylation catalyst. The reaction may be carried out in an excess of alcohol, or with a near stoichiometric amount of alcohol by performing the reaction in an inert solvent.
专利号:US-2003060648-A1 优先权日:2001-04-11 标题 :Facile synthesis of symmetric esters of alkylenebisphosphonic acids
专利号:US-6316519-B1 优先权日:1997-02-19 标 题 :Molecular weight controlled polymers by photopolymerization 发明人:BERGE CHARLES THOMAS; DESOBRY VINCENT 权利人:DU PONT 摘要:Synthesis of linear acrylic polymers and copolymers having controlled molecular weight by the photoinitiated free radical polymerization of vinyl monomers in the presence of chain transfer agents to produce polymers useful in coating compositions and the like, including printing inks.
专利号:US-2005234257-A1 优先权日:2001-04-11 标 题 :Facile synthesis of symmetric esters of alkylenebisphosphonic acids
[参考文献]: C T Olson, Et Al. Identification Of Urinary Metabolites Of The Nephrotoxic Hydrocarbon 2,2,4-Trimethylpentane In Male Rats. Biochem Biophys Res Commun. 1985 Jul 16;130(1):313-6.
合成参考文献
摘要:Ishihara, K.; Yamamoto, H., Science of Synthesis, (2005) 6, 439.