CAS: 162536-40-5; Tert-Butyl ((2S,3R)-4-Chloro-3-Hydroxy-1-Phenylbutan-2-yl)Carbamate

相似化合物

165727-45-7 102123-74-0 106454-69-7

上下游产品

CAS号102123-74-0 (3S)-3-(叔丁氧羰基)氨... | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号369362-96-9 (2S,3R)-2-amino... | CAS号13734-34-4 B°C-L-苯丙氨酸 | CAS号60398-41-6 B°C-L-Phe-CHN2 | CAS号67729-36-6 B°C-Phe-O-COO-isoBu | CAS号51987-73-6 N-B°C-L-苯丙氨酸甲酯 | CAS号198904-31-3 阿扎那韦

(3S)-3-Dibenzylamino-1-Chloro-2-Oxo-4-Phenylbutane置于sodium Tetrahydroborate,乙醇,10 Wt% Pd(Oh)2 On Carbon,氢气,三乙胺体系中,用 甲醇,二氯甲烷 用作溶剂,-3.0~30.0 °C,101.33 Kpa 条件下,反应 4.5H,反应生成(2R,3S)-3-(叔丁氧羰基氨基)-1-氯-2-羟基-4-苯基丁烷
参考文献:一种(2R,3S)-1-氯-3-叔丁氧酰胺基-4-苯基-2-丁醇的制备方法
标题:一种(2R,3S)-1-氯-3-叔丁氧酰胺基-4-苯基-2-丁醇的制备方法
摘要:本发明一种(2R,3S)‑1‑氯‑3‑叔丁氧酰胺基‑4‑苯基‑2‑丁醇的制备方法,以l‑苯丙氨酸为原料,采用苄基保护并酯化,然后经nmm催化生成混酐化合物,再与重氮甲烷反应生成重氮酮,经还原反应,钯碳还原,最终得到中间体 (2R,3S)‑1‑氯‑3‑(叔丁氧酰胺基)‑4‑苯基‑2‑丁醇.本发明采用廉价的苄基保护了氨基,合成路线合理,操作工艺简单,安全且产率高,通过此方法可以很好地实现工业化,提高了生产效率.

专利信息

专利号:US-7083973-B2
优先权日:2000-08-16
标题 :Stereoselective reduction of substituted oxo-butanes
发明人：PATEL RAMESH N; CHU LINDA
权利人:BRISTOL MYERS SQUIBB CO
摘要:The present invention relates to a process for the stereoselective enzymatic reduction of 1-halo-2-oxo-3-(protected)amino-4-substituted-butanes utilizing certain species of Rhodococcus and Brevibacterium . The product 1-halo-2-hydroxy-3-(protected)amino-4-substituted-butanes, which are useful as intermediates in the synthesis of compounds that are inhibitors of ACE, renin and HIV proteases, are obtained in high yield and, particularly, in very high diastereomeric purity. The process is advantageously highly selective for the (3S,2R) enantiomer of the product.