CAS: 1478-53-1; Difluoromethylphosphonicaciddiethylester

相似化合物

65094-22-6 682-30-4 2942-58-7

上下游产品

Chlorodifluoromethane sodium diethyl phosphite phosgene [(diethoxyphosphoryl)difluoromethyl]zinc bromidediethyl (5-bromo-1,1-difluoropentyl)phosphonic acid 5-iodo-1,1-difluoro-1-(diethylphosphono)pentane 3-O-Benzyl-5,6-dideoxy-6-(diethoxyphosphinyl)-6,6-difluoro-1,2-O-isopropylidene-β-D-ribo-hexofuranose benzyl 6-deoxy-6-[(diethylphosphono)difluoromethyl]-2,3,4-tri-O-benzyl-β-D-glucopyranoside

📜溴氟甲基膦酸二乙酯置于盐酸,异丙基氯化镁体系中,化学反应生成二氟甲基膦酸二乙酯
参考文献:一种有用的镁试剂,可通过金属-卤素交换反应从溴二氟甲基膦酸二乙酯制备1,1-二氟-2-羟基膦酸盐
标题:一种有用的镁试剂,可通过金属-卤素交换反应从溴二氟甲基膦酸二乙酯制备1,1-二氟-2-羟基膦酸盐
摘要:将(eto)2 P(o)cf 2 Br(1)在thf中用异丙基氯化镁在低温下处理时,得到镁物质(2),该镁物质与强亲电试剂(hcl,Tmccl,卤素,醛和酮)发生反应.产物的形成在很大程度上取决于反应条件.在-78至0oc之间使用1.5当量的2,可以实现90%以上的醛和酮转化为2-羟基膦酸酯(7和8).这些化合物(7和8)在碱(nah,Lda)存在下重排成2,2-二氟乙基磷酸酯,而不会同时形成1,1-二氟烯烃.
Doi:10.1016/s0022-328X(96)06541-2

专利信息

专利号:US-12331006-B2
优先权日:2018-05-25
标 题 :Process for the synthesis of (s) 3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid
发明人：SILVERMAN RICHARD B; MOSCHITTO MATTHEW
权利人:UNIV NORTHWESTERN
摘要:Provided herein are processes, compounds and compositions for making (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid. Also provided herein a pharmaceutical compositions containing (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid.

专利号:EP-4410773-A2
优先权日:2018-05-25
标 题:Process for the synthesis of (s) 3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid

专利号:US-4478763-A
优先权日:1982-10-20
标题:Process for preparing alpha-fluorinated alkanediphosphonates
发明人：MCKENNA CHARLES E
权利人:UNIV SOUTHERN CALIFORNIA
摘要:A method for the production of alpha-fluorinated methane diphosphonates consists of the reaction of diphosphonate esters with a strong base, preferably potassium t-butoxide, and perchloryl fluoride to produce alpha-mono and alpha,alpha-difluorinated derivatives which can be converted to the corresponding acids by mild hydrolysis. The synthesis of unsymmetrical alpha-fluorinated methanediphosphonate esters followed by selective hydrolysis produces unsymmetrical diesters of diphosphonic acids.

专利号:EP-3784649-B1
优先权日:2018-05-25
标 题 :Process for the synthesis of (s)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid

专利号:US-4943629-A
优先权日:1988-08-12
标 题:Antidiabetic alpha-substituted phosphonates
发明人：DEVRIES VERN G; CLAUS THOMAS H; FLOYD JR MIDDLETON B; AYRAL-KALOUSTIAN SEMIRAMIS
权利人:AMERICAN CYANAMID CO
摘要:Alpha-substituted phosphonates are disclosed which stimulate the enzyme fructose-1,6-bisphosphatase and inhibit the enzyme 6-phosphofructo-1-kinase, thereby lowering glucose levels in mammals. These alpha-substituted phosphonates may thus be used to treat hyperglycemia and/or diabetes. Processes for the synthesis of the alpha-substituted phosphonates are also disclosed.