CAS: 145689-41-4; 2-(2,3-Difluorophenyl)Acetic Acid

相似化合物

145689-34-5 126163-30-2 132992-28-0

上下游产品

CAS号1489-53-8 1,2,3-三氟苯 | CAS号105-56-6 氰乙酸乙酯 | CAS号141428-47-9 2,3-二氟-6-硝基苯乙酸 | CAS号875003-88-6 (2,3-difluoro-5... | CAS号126163-30-2 2,3-二氟苯乙醇

📜2,3-二氟苯胺置于盐酸,四丁基氯化铵,水,Copper Diacetate,Sodium Nitrite体系中,用 二氯甲烷,水 用作溶剂,化学反应 10.0H,反应生成2,3-二氟苯乙酸
参考文献:一种氟代苯乙酸的制备方法
标题:一种氟代苯乙酸的制备方法
摘要:本发明涉及化学合成领域,特别是涉及一种氟代苯乙酸的制备方法.本发明提供一种氟代苯乙酸的制备方法,所述制备方法包括如下步骤:重氮化加成反应:将式ii化合物在含有偏二氯乙烯,酸,重氮试剂,相转移催化剂和铜系催化剂的体系中反应生成式iii化合物:水解反应:将式iii化合物在酸存在的条件下水解生成式i化合物.本发明所提供的制备方法原料简单易得,操作简便,原料成本低,反应条件温和,危险性低,无需使用价格高昂的贵金属催化剂和复杂的工业操作手段,产品质量稳定,因此宜于实现大规模工业化生产.

专利信息

专利号:US-11897857-B2
优先权日:2019-02-15
标 题 :Isotopically-stabilized tetronimide compounds
发明人：OLSEN MARK JON; SEERDEN JEAN PAUL
权利人:UNIV MIDWESTERN
摘要:Isotopically-stabilized tetronimide compounds comprising one or more deuterium atoms, derivatives, and intermediates, thereof, including methods for their synthesis, pharmaceutical compositions thereof, and methods of using these compounds to interact with target molecules in cell-free samples, cell- and tissue-based assays, animal models, and in a subject are disclosed. One aspect relates to molecules that modulate the expression or catalytic activity of aspartyl (asparaginyl) β-hydroxylase (ASPH) within or on the surface of a cell. Other aspects of the invention relate to use of the molecules disclosed herein to diagnose, ameliorate, or treat cell proliferation disorders and related diseases. Related aspects include uses of the compounds to modulate the activity of viruses, as anti-hyperlipidemia agents, and as agents to ameliorate or treat thrombosis and related cardiovascular and metabolic disorders.

专利号:US-6143750-A
优先权日:1997-06-18
标 题 :Alpha 1a adrenergic receptor antagonists
发明人：PATANE MICHAEL A; BOCK MARK G
权利人:MERCK & CO INC
摘要:This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia are achieved.

专利号:WO-9857640-A1
优先权日:1997-06-18
标 题 :Alpha 1a adrenergic receptor antagonists
发明人：PATANE MICHAEL A; BOCK MARK G
权利人:MERCK & CO INC; PATANE MICHAEL A; BOCK MARK G
摘要:This invention relates to nitrogen containing heterocyclic compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenoceptor antagonists. More particularly, the compounds of the present invention are useful for treating benign prostatic hyperplasia.

专利号:CN-117049984-B
优先权日:2023-07-25
标题 :Synthesis method of 4- [ [ (1, 1-dimethyl ethoxy) carbonyl ] amino ] -alpha, alpha-difluorophenylacetic acid ethyl ester

专利号:CN-1242007-A
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising such compounds, and methods of inhibiting beta amyloid peptide release and/or its synthesis using such compounds