CAS: 13686-49-2; 1-(2-Bromoethyl)Naphthalene

该化合物是一种有机化合物,其特点是以溴乙基组物替代氯化萘脊椎,其特点是一种有机化合物,一般视温度和纯度而定,其颜色无色的黄色液体或固态,其特点是无色的,视温度和纯度而定;溴原子的存在具有明显的反应性,使其成为有机合成的有用中间体,特别是在通过核生殖替代反应形成碳碳-碳结层方面.该化合物一般在水中无法溶解,但在乙醇和乙醇等有机溶剂中可溶解.该化合物的分子结构有助于其芳香特性,从而影响其再活动及与其他化学物种的相互作用.此外,1-(2-溴乙基)甲型甲型乙烷在实验室或工业环境中使用时可能具有中度毒性,需要小心处理,并采取适当的安全措施.与许多卤化合物一样,在与该物质合作或处置该物质时必须考虑环境影响和管制准则.

结构式图片

相似化合物

41332-02-9 1127-76-0 2765-18-6

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上下游产品

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合成工艺路线路线简述

    📜1-萘乙酸置于硼烷铵络合物,溴化钛(Iv)体系中,用 1,2-二氯乙烷 用作溶剂,以96 %的收率获得1-(2-溴乙基)萘
    参考文献:平衡芳基羰基和甲醇选择性脱氧卤化的路易斯酸度和碳正离子稳定性
    标题:平衡芳基羰基和甲醇选择性脱氧卤化的路易斯酸度和碳正离子稳定性
    摘要:利用适当的金属卤化物路易斯酸作为羰基活化剂和卤素载体,并结合硼烷-氨作为还原剂,实现了芳基醛,酮,羧酸和酯的脱氧卤化.通过将碳阳离子中间体的稳定性与路易斯酸的有效酸度相匹配来实现选择性.取代基和取代模式显着影响所需的溶剂/路易斯酸组合.这些因素的逻辑组合也已应用于醇向烷基卤的区域选择性转化.
    Doi:10.1021/acs.Orglett.3C01462

    海关参考信息

    专利信息


    专利号:US-5948903-A
    优先权日:1991-01-11
    标题:Synthesis of 3-deazapurines
    发明人：COOK P DAN; ACEVEDO OSCAR L; ANDREWS ROBERT S
    权利人:ISIS PHARMACEUTICALS INC
    摘要:This invention relates to compounds based on the 3-deazapurines ring system and to methods for making such compounds. The invention also generally relates to the field of 'antisense' agents, agents that are capable of specific hybridization with a nucleotide sequence of an RNA. The 3-deazapurine-containing compounds of this invention can be useful for modulating the activity of RNA when incorporated into oligonucleotides. Oligonucleotides and their analogs are used for a variety of therapeutic and diagnostic purposes, such as treating diseases, regulating gene expression in experimental systems, assaying for RNA and for RNA products through the employment of antisense interactions with such RNA, diagnosing diseases, modulating the production of proteins and cleaving RNA in site specific fashions.

    专利号:US-5750692-A
    优先权日:1990-01-11
    标 题 :Synthesis of 3-deazapurines
    发明人：COOK P DAN; ACEVEDO OSCAR L; ANDREWS ROBERT S
    权利人:ISIS PHARMACEUTICALS INC
    摘要:This invention relates to compounds based on the 3-deazapurines ring system and to methods for making such compounds. The invention also generally relates to the field of 'antisense' agents, agents that are capable of specific hybridization with a nucleotide sequence of an RNA. The 3-deazapurine-containing compounds of this invention can be useful for modulating the activity of RNA when incorporated into oligonucleotides. Oligonucleotides and their analogs are used for a variety of therapeutic and diagnostic purposes, such as treating diseases, regulating gene expression in experimental systems, assaying for RNA and for RNA products through the employment of antisense interactions with such RNA, diagnosing diseases, modulating the production of proteins and cleaving RNA in site specific fashions.

    专利号:US-4528195-A
    优先权日:1978-02-01
    标题:Imidazole derivatives and salts thereof, their synthesis and intermediates and pharmaceutical formulations
    发明人：THOROGOOD PETER B
    权利人:THOROGOOD PETER B
    摘要:Pharmaceutical formulations comprising an imidazole (or pharmaceutically acceptable salt thereof) of formula: ##STR1## wherein (i) A is an aliphatic hydrocarbon residue of from 1 to 4 carbon atoms and R is a naphthyl, tetrahydronaphthyl, heterocyclyl, arylthio, arylalkylthio, aryloxy, arylalkyloxy, arylhydroxymethylene, arylcarbonyl, arylalkylcarbonyl, alkyloxy, alkylthio or a substituted cycloalkyl or cycloalkenyl group or n (ii) A is an --SO 2 -- group and R is aryl or heterocyclyl or n (iii) A is a chemical bond and R is a heterocyclyl or n Some of these imidazoles and salts are novel. n Methods of preparing the imidazoles are disclosed. The imidazoles and their salts are useful in the treatment or prophylaxis of thrombo-embolic conditions, shock and angina pectoris.

    专利号:CN-1065238-C
    优先权日:1993-01-29
    标题 :Intermediate compounds suitable for the synthesis of modified oligodeoxynucleotides

    专利号:CN-104387222-A
    优先权日:2014-09-29
    标 题:A class of highly condensed ring [6] helicene compounds based on fluorene and naphthalene and its synthesis method

    专利号:CN-114716296-A
    优先权日:2022-03-25
    标题:A kind of efficient halogenation synthesis method of alkyl halide

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    主要参考文献

    参考标题:Diversity‐oriented Synthesis Of Aliphatic Fluorides Via Reductive C(Sp3)−c(Sp3) Cross‐coupling Fluoroalkylation
    作者:Jie Sheng,Hui‐qi Ni,Shan‐xiu Ni,Yan He,Ru Cui,Guang‐xu Liao,Kang‐jie Bian,Bing‐bing Wu,Xi‐sheng Wang |发布日期:2021.6.25
    摘要:Catalyst And Alkyl Bromide Whereas The Generation Of Monofluoroalkyl Radical Is Not Involved In The Rate-Determining Step. This Strategy Provides A General And Efficient Method For The Synthesis Of Aliphatic Fluorides.

    合成参考文献


    参考文献:10.1007/s00044-015-1330-z
    摘要:Wright BD, Deblock MC, Wagers PO, Duah E, Robishaw NK, Shelton KL, Southerland MR, DeBord MA, Kersten KM, McDonald LJ, Stiel JA, Panzner MJ, Tessier CA, Paruchuri S, Youngs WJ. Anti-tumor activity of lipophilic imidazolium salts on select NSCLC cell lines. Medicinal Chemistry Research. 2015 Feb 13;24(7):2838–61. doi: 10.1007/s00044-015-1330-z.
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