CAS: 13078-76-7; 2-(3,4-Dimethoxyphenyl)-N-Methylethanamine,Hydrochloride

该化合物是一种合成有机化合物,属于替代苯乙胺的类别,在3和4个位置上有一个以两种甲氧基组替代的苯环,一个乙胺侧链和一个氮原子上的甲基组,形成一种盐碱盐,以增进稳定性.由于该化合物在结构上与...

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CAS号40511-15-7 1-(3,4-二甲氧基苯基)-... | CAS号29705-80-4 1-(4-甲氧基苯基)-2-(... | CAS号23313-68-0 维拉帕米盐酸盐 | CAS号6514-05-2 N-甲基紫堇碱

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    📜1-(3,4-二甲氧基苯基)-2-(甲基氨基)乙酮盐酸盐置于aluminum (III) Chloride,5%-Palladium/activated Carbon 氢气,氯化铵,Sodium Hydroxide,盐酸体系中,用 水,甲苯,丙酮 用作溶剂,5.0~85.0 °C,344.75 Kpa 条件下,反应 42.0H,反应生成3,4-二甲氧基-N-甲基苯乙胺盐酸盐
    参考文献:Process For Preparing N-Methyl-3,4-Dimethoxyphenylethylamine
    标题:Process For Preparing N-Methyl-3,4-Dimethoxyphenylethylamine
    摘要:提供了用于制备维拉帕米的中间体以及它们的制备方法.

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    专利号:US-5057624-A
    优先权日:1989-03-31
    标 题 :Process for the synthesis of the n-methyl-3,4-dimethoxyphenylethylamine
    发明人：CANNATA VINCENZO; TAMERLANI GIANCARLO; ZAGNONI GRAZIANO
    权利人:ALFA WASSERMANN SPA
    摘要:New process for the synthesis of the N-methyl-3,4-dimetoxyphenylethylamine of formula ##STR1## intermediate in the synthesis of the drug internationally known as verapamil. The process starts from the 3,4-dimethoxybenzaldehyde which, by means of a Darzens condensation, gives an epoxyester that, by alkaline hydrolysis and subsequent decarboxylation, gives the 3,4-dimethoxyphenylacetaldehyde. This aldehyde gives the amine of formula I by reaction with monomethylamine followed by reduction with sodium borohydride.

    专利号:CA-2013080-C
    优先权日:1989-03-31
    标 题:Process for the synthesis of the n-methyl-3,4-dimethoxyphenylethylamine

    专利号:EP-0389876-A1
    优先权日:1989-03-31
    标题:New process for the synthesis of the N-methyl-3,4-dimethoxyphenylethylamine

    专利号:EP-0389876-B1
    优先权日:1989-03-31
    标 题 :New process for the synthesis of the n-methyl-3,4-dimethoxyphenylethylamine

    专利号:HR-P940599-A2
    优先权日:1989-03-31
    标题 :New process for the synthesis of the n-methyl-3,4-dimethoxyphenylethylamine

    专利号:IE-63954-B1
    优先权日:1989-03-31
    标题 :New process for the synthesis of the n-methyl-3,4-dimethoxyphenylethylamine

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    合成参考文献


    摘要:Journal of Pharmacology and Experimental Therapeutics., 52(101), 1934
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