CAS: 1201902-80-8; 4-(Carboxymethyl)-2-((R)-1-(2-(2,5-Dichlorobenzamido)Acetamido)-3-Methylbutyl)-6-Oxo-1,3,2-Dioxaborinane-4-Carboxylic Acid

上下游产品

Ν,Ν',Ν''-[boroxin-2,4,6-triyltris[[(1R)-3-methylbutane-1,1-diyl]imino(2-oxoethane-2,1-diyl)]]tris(2,5-dichlorobenzamide) citric acid Ixazomib 2,5-dichlorobenzoic acid

2,5-二氯苯甲酸置于盐酸,Lithium Hydroxide Monohydrate,异丁基硼酸,1-羟基苯并三唑,盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺体系中,用 甲醇,正己烷,二氯甲烷,水,乙酸乙酯 用作溶剂,化学反应 14.68H,反应生成艾沙佐米柠檬酸盐
参考文献:依沙佐米合成工艺研究
标题:依沙佐米合成工艺研究
摘要:本发明公开了一种依沙佐米的合成方法,通过该方法可以大大提高目标产物的收率和纯度.

专利信息

专利号:US-11542283-B2
优先权日:2018-05-28
标题 :Synthesis of peptide borate ester compound and use thereof
发明人：QIN YANRU
权利人:JIANGSU CHIA TAI FENGHAI PHARMACEUTICAL CO LTD
摘要:Provided are a peptide borate ester compound or a pharmaceutically acceptable salt thereof, a preparation method therefor, and pharmaceutical use thereof. The peptide borate ester compound or pharmaceutically acceptable salt thereof has a structure as shown in Formula (I), and is useful in the preparation of proteasome inhibitors to treat solid tumors and hematoma.

专利号:US-2021214377-A1
优先权日:2018-05-28
标题 :Synthesis of peptide borate ester compound and use thereof

专利号:CA-3101824-A1
优先权日:2018-05-28
标题 :Synthesis of peptide borate ester compound and use thereof

专利号:CN-115785137-A
优先权日:2018-05-28
标 题:Synthesis and application of a kind of peptide boronate compound

专利号:JP-7314259-B2
优先权日:2018-05-28
标 题:Synthesis and use of peptide boronic ester compounds

专利号:CN-110540547-A
优先权日:2018-05-28
标题:Synthesis and application of a kind of peptide boronate compound