CAS: 88756-83-6; Rel-(3Ar,4S,6R,6As)-6-Aminotetrahydro-2,2-Dimethyl-4H-Cyclopenta-1,3-Dioxol-4-Ol

英文名称Rel-(3Ar,4S,6R,6As)-6-Aminotetrahydro-2,2-Dimethyl-4H-Cyclopenta-1,3-Dioxol-4-Ol
中文名称rel-(3aR,4S,6R,6aS)-6-氨基四氢-2,2-二甲基-4H-环戊-1,3-二氧杂环己烷-4-醇
IUPAC名称(3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-ol
其它别名Ticagrelor Related Compound 3 ((+/-)-6-Aminotetrahydro-2,2-Dimethyl-4H-Cyclopenta-1.3-Dioxol-4-Ol); (3As,4R,6S,6Ar)-Rel-6-Aminotetrahydro-2,2-Dimethyl-4H-Cyclopenta-1,3-Dioxol-4-Ol; (3As,4R,6S,6Ar)-6-Amino-2,2-Dimethyl-4,5,6,6A-Tetrahydro-3Ah-Cyclopenta[d][1,3]Dioxol-4-Ol; 4H-Cyclopenta-1,3-Dioxol-4-Ol, 6-Aminotetrahydro-2,2-Dimethyl-, (3Ar,4S,6R,6As)-Rel-; 1-Amino-2,3-O-Isopropylidene Dioxycyclopentane-4-Ol
CAS编号88756-83-6
分子式:C8H15NO3分子量:173.21
产品CID: 1906310
产品分类有机原料→分析科学→药物杂质对照品→心脑血管药→替格瑞洛杂质→(3aS,4S,6R,6aR)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol (Ticagrelor Impurity）

相似结构搜索
InChIKey: AXPYGRDXRLICKY-JRTVQGFMSA-N
InChI=1S/C8H15NO3/c1-8(2)11-6-4(9)3-5(10)7(6)12-8/h4-7,10H,3,9H2,1-2H3/t4-,5+,6+,7-/m1/s1
计算化学: 氢键受体数4.0氢键供体数2.0可旋转键数*

相似化合物

155899-66-4 274693-53-7 2381860-79-1

MSDS等安全信息

上下游产品

cyclopenta-1,3-diene hept-5-eneN-(benzyloxycarbonyl)-2-oxa-3-azabicyclo2.2.1hept-5-ene hept-5-ene(+/-)-3-(3,5-dinitrobenzoyl)-2-oxa-3-azabicyclo2.2.1hept-5-ene pyrimidin-2-yl>amino>-2,3-O-isopropylidene-1,2,3-cyclopentanetriol(+/-)-(1α,2β,3β,4α)-4-2-amino-6-chloro-5-(4-chlorophenyl)azopyrimidin-2-ylamino-2,3-O-isopropylidene-1,2,3-cyclopentanetriol (+/-)-5'-Noraristeromycin (3aS,4R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydro-3aH-cyclo-penta[d][1,3]dioxol-4-aminium (2R,3R)-2,3-bis(benzoyloxy)-3-carboxypropanoate dibenzoyl-L-tartrate (3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta-[d][1,3]dioxol-4-ol D-(-)-mandelate

合成工艺路线路线简述

合成目标产物 Ticagrelor Related Compound 3 主要起始原料 Benzyl 3-Oxa-2-Aza-Bicyclo[2.2.1]Hept-5-Ene-2-Carboxylate
188789-31-3 = 88756-83-6
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 1.5 H
标题:1-Chloro-1-Nitrosocyclohexane
作者:Keck,Gary E.; Palani,Anandan; Pons,Valerie; Motherwell,William B.
参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2013 卷标:1 页码:1-3]

188789-28-8 = 88756-83-6
反应条件:1.1 Reagents: P-Toluenesulfonic Acid1.2 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol
标题:2-Aza-3-Oxabicyclo[2.2.1]Heptene Hydrochloride: An Exceptionally Versatile Synthon For Carbocyclic Sugars And Nucleosides
作者:Ranganathan,Subramania; George,K. Shaji
参考文献:Tetrahedron 日期:1997 卷标:53(9) 页码:3347-3362

📜3-噁-2-氮杂双环[2.2.1]-5-庚烯-2-羧酸苄酯置于palladium On Activated Charcoal Potassium Permanganate,氢气,Magnesium Sulfate,对甲苯磺酸体系中,用甲醇,水作为反应溶剂,化学反应 26.0H,反应生成替卡格雷相关化合物3
参考文献:2-Aza-3-Oxabicyclo[2.2.1]Heptene Hydrochloride: An Exceptionally Versatile Synthon For Carbocyclic Sugars And Nucleosides
标题:2-Aza-3-Oxabicyclo[2.2.1]Heptene Hydrochloride: An Exceptionally Versatile Synthon For Carbocyclic Sugars And Nucleosides
摘要:The Transformation Of Cyclopentadiene To 5'-Desmethylene 1'-Aza Carbocyclic Sugars Has Been Achieved In Four Steps: 1. Cycloaddition Of Chloronitrosocyclohexane To 2-Aza-3-Oxabicyclo[2.2.1]Heptene Hydrochloride In Etoh-Et(2)O,2. Nitrogen Functionalization,3. Cis Hydroxylation And 4. N-O Bond Cleavage. The Protocols Provided Enable Practical Access To A Range Of 5'-Desmethylene Carbocyclic Sugar Analogs Whose Utility Has Been Illustrated With Synthesis Of A Novel 5'-Desmethylene Analog Of Aristeromycin. (C) 1997 Elsevier Science Ltd.
DOI:10.1016/s0040-4020(97)00057-4