CAS: 86-96-4; Quinazoline-2,4(1H,3H)-Dione

该化合物是一种杂交有机化合物,其特点是其引信为苯并基和尿素,具有显著的热稳定性和化学抗药性,使其适合聚合物添加剂和特殊涂层的高性能应用,其硬分子框架在纳入复合材料时有助于增强机械特性.苯并乙烯尿素还具有作为制药合成中的一种前体的潜力,因为它能够形成稳定的氢结.该化合物在普通溶剂中的溶解性较低,因此需要专门配制技术,但这种特性在控制释放应用中可能具有优势.其紫外线稳定性进一步扩大了其在受恶劣环境条件影响的材料中的用途.

英文名称Quinazoline-2,4(1H,3H)-Dione
中文名称喹唑啉-2,4(1H,3H)-二酮
IUPAC名称quinazoline-2,4(1H,3H)-dione
其它别名Quinazoline-2,4-dione; 2,4(1H,3H)-Quinazolinedione
CAS编号86-96-4
MFCD编号:MFCD00006699
EINECS号:201-712-6
FDA UNII编号:18K00A531C
分子式:C8H6N2O2
分子量:162.15
产品CID: 1873554
产品分类医药中间体 → 杂环化合物中间体 → 喹啉类化合物

相似结构搜索
InChIKey: SDQJTWBNWQABLE-UHFFFAOYSA-N
InChI=1S/C8H6N2O2/c11-7-5-3-1-2-4-6(5)9-8(12)10-7/h1-4H,(H2,9,10,11,12)…
计算化学: 氢键受体数4.0氢键供体数2.0可旋转键数0.0

MSDS等安全信息

GHS符号GHS07
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P305+P351+P338
安全声明24/25-22
WGK Germany2

欧盟法规

C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

2242-77-5 = 86-96-4
反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Methanol,Water; Ph 10,Reflux
标题:Discovery Of Novel Quinazolines As Potential Anti-Tubulin Agents Occupying Three Zones Of Colchicine Domain
作者:Li,Wenlong; Et Al
参考文献:Bioorganic Chemistry 日期:2019 卷标:83 页码:380-390]

88-68-6 = 86-96-4
反应条件:1.1 Reagents: Potassium Carbonate,Sulfur Solvents: Dimethylformamide1.2 Reagents: Oxygen1.3 Reagents: Hydrochloric Acid Solvents: Water
标题:Convenient Synthesis Of Heterocycles By Sulfur-Assisted Carbonylation At Ordinary Pressure And Temperature
作者:Mizuno,Takumi; Et Al
参考文献:Heteroatom Chemistry 日期:1994 卷标:5 页码:437-40]

57-13-6 = 86-96-4
反应条件:1.1 Solvents: Dimethylacetamide; 3 Min; Rt
标题:A Green,Facile,And One-Pot Synthesis Of 2,4-(1H,3H)-Quinazolinediones Under Microwave Irradiations
作者:Nikpour,Farzad; Et Al
参考文献:Chemistry Letters 日期:2005 卷标:34(10) 页码:1438-1439]

57-13-6 = 86-96-4
反应条件:1.1 3 H,180 °C; 180 °C -> 120 °C1.2 Reagents: Sodium Hydroxide Solvents: Water1.3 Reagents: Hydrochloric Acid Solvents: Water; Acidified
标题:Synthesis,Characterisation And Biological Evaluation Of Quinazoline Derivatives As Novel Anti-Microbial Agents
作者:Prabhakar,V.; Et Al
参考文献:Organic Chemistry: Current Research 日期:2016 卷标:5(4) 页码:174/1-174/14]

= 86-96-4
反应条件:1.1 Solvents: Water
标题:4H-3,1-Benzoxazin-4-Ones. Ii. Reaction Of 1,2-Dihydro-2-Imino-4H-3,1-Benzoxazin-4-Ones With Nucleophilic Reagents And Their Conversion To 1,2,3,4-Tetrahydroquinazoline-2,4-Diones; Mechanism Of Condensation Reactions Of The Carboxyl Group Triggered By Carbodiimides
作者:Doleschall,Gabor; Et Al
参考文献:Monatshefte Fuer Chemie 日期:1964 卷标:95(4-5) 页码:1068-82]

590-28-3 = 86-96-4
反应条件:1.1 Reagents: Acetic Acid Solvents: Polyethylene Glycol; Rt -> 60 °C; 10 Min,50 - 60 °C
标题:A Facile And Convenient Approach For The One-Pot Synthesis Of 2,4(1H,3H)-Quinazolinediones
作者:Sharafi-Kolkeshvandi,Mahnaz; Et Al
参考文献:Chinese Chemical Letters 日期:2012 卷标:23(4) 页码:431-433]

590-28-3 = 86-96-4
反应条件:1.1 Reagents: Acetic Acid Solvents: Water; Overnight,Rt1.2 Reagents: Sodium Hydroxide; 4 H,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; < Ph 1,Rt
标题:Eco-Efficient One-Pot Synthesis Of Quinazoline-2,4(1H,3H)-Diones At Room Temperature In Water
作者:Tian,Xin-Chuan; Et Al
参考文献:Chemical & Pharmaceutical Bulletin 日期:2014 卷标:62(8) 页码:824-829]

610-15-1 = 86-96-4
反应条件:1.1 Reagents: Triethylamine Catalysts: Selenium Solvents: Tetrahydrofuran; 11 H,2 Mpa,170 °C
标题:Metal And Phosgene-Free Synthesis Of 1H-Quinazoline-2,4-Diones By Selenium-Catalyzed Carbonylation Of O-Nitrobenzamides
作者:Wu,Xiaowei; Et Al
参考文献:Tetrahedron Letters 日期:2010 卷标:51(11) 页码:1500-1503]

118-48-9 = 86-96-4
反应条件:1.1 Reagents: Urea Solvents: Dimethylformamide
标题:Syntheses Of Heterocycles. Lxxxix. Reactions Of Isatoic Anhydride With Derivatives Of Urea And Thiourea
作者:Kappe,Thomas; Et Al
参考文献:Monatshefte Fuer Chemie 日期:1967 卷标:98(1) 页码:214-18]

1885-29-6 = 86-96-4
反应条件:1.1 Reagents: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene Solvents: Ethylene Glycol; 24 H,1 Bar,60 °C
标题:Room-Temperature Conversion Of Co2 Into Quinazoline-2,4(1H,3H)-Dione Using Deep Eutectic Solvents At Atmospheric Pressure With High Efficiency
作者:Chen,Yu; Et Al
参考文献:Reaction Chemistry & Engineering 日期:2022 卷标:7(9) 页码:1968-1977]

1885-29-6 = 86-96-4
反应条件:1.1 Catalysts: Phosphonium,Tributylethyl-,Salt With 1-Methyl-2,4-Imidazolidinedione (1:1); 30 H,0.1 Mpa,353.15 K
标题:Efficient Synthesis Of Quinazoline-2,4(1H,3H)-Dione Via Simultaneous Activated Co2 And 2-Aminobenzonitrile By 1-Methylhydantoin Anion-Functionalized Ionic Liquid Through The Multiple-Site Cooperative Interactions
作者:Chen,Tingting; Et Al
参考文献:Acs Sustainable Chemistry & Engineering 日期:2022 卷标:10(32) 页码:10699-10711]

1885-29-6 = 86-96-4
反应条件:1.1 Reagents: Carbon Dioxide Solvents: Water; Rt -> 150 °C; 5 H,5 Mpa,150 °C
标题:Carbon Dioxide Mediated Novel Synthesis Of Quinazoline-2,4(1H,3H)-Dione In Water
作者:Rasal,Kalidas B.; Et Al
参考文献:Organic Process Research & Development 日期:2016 卷标:20(12) 页码:2067-2073]

2242-77-5 = 86-96-4
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol,Water; 3 H,Ph 10,Reflux; Reflux -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 3,Rt
标题:Discovery Of Novel Potent And Selective Ligands For 5-Ht2A Receptor With Quinazoline Scaffold
作者:Deng,Xinxian; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2015 卷标:25(18) 页码:3970-3974]

88-68-6 = 86-96-4
反应条件:1.1 Reagents: Diglyme; 5 H,Reflux
标题:Synthesis And Characterization Of New Bistriazole Quinazolinediones And Their Urease Inhibition Activities
作者:Akyuz,Gulay; Et Al
参考文献:Letters In Organic Chemistry 日期:2023 卷标:20(3) 页码:258-264]

88-68-6 = 86-96-4
反应条件:1.1 Reagents: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene,Sulfur Solvents: Tetrahydrofuran
标题:Facile Synthesis Of 2,4-Dioxo-1,2,3,4-Tetrahydroquinazolines By Sulfur-Assisted Carbonylation With Carbon Monoxide
作者:Miyata,Toshiyuki; Et Al
参考文献:Heteroatom Chemistry 日期:1991 卷标:2(4) 页码:473-5]

88-68-6 = 86-96-4
反应条件:1.1 Reagents: Oxygen Catalysts: Cobalt Salen Solvents: Methanol
标题:Salcomine
作者:Parker,Kathlyn A.; Et Al
参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001 卷标:1 页码:1-3]

= 86-96-4
反应条件:1.1 Reagents: Diisopropylcarbodiimide Solvents: Dimethylformamide; 20 Min,130 °C2.1 Reagents: Sulfuric Acid Solvents: Acetic Acid; 15 Min,110 °C3.1 Reagents: Potassium Hydroxide Solvents: Water; 15 Min,Reflux3.2 Reagents: Acetic Acid; Acidified
标题:Oxidative Ring Expansion Of Spirocyclic Oxindole Derivatives
作者:Bergman,Jan; Et Al
参考文献:Journal Of Organic Chemistry 日期:2014 卷标:79(19) 页码:9065-9073]

530-62-1 + 118-48-9 = 86-96-4
反应条件:1.1 Reagents: Ammonia Solvents: Dichloromethane; 30 Min,Reflux1.2 2 H,Reflux
标题:One-Pot Syntheses Of Some New 2,4(1H,3H)-Quinazolinedione Derivatives In The Absence Of Catalyst
作者:Mohammadi,Ali Asghar
参考文献:Journal Of Heterocyclic Chemistry 日期:2017 卷标:54(3) 页码:2075-2078]

88-68-6 = 86-96-4
反应条件:1.1 Reagents: Triphenyl Phosphite,1,5-Diazabicyclo[4.3.0]Non-5-Ene Solvents: Acetonitrile; 1 H,Rt
标题:Synthesis Of N-Unsubstituted And N3-Substituted Quinazoline-2,4(1H,3H)-Diones From O-Aminobenzamides And Co2 At Atmospheric Pressure And Room Temperature
作者:Zhang,Lin; Et Al
参考文献:Organic Letters 日期:2023 卷标:25(14) 页码:2471-2475]

610-15-1 = 86-96-4
反应条件:1.1 Catalysts: Stannous Chloride,Dichlorobis(Triphenylphosphine)Palladium Solvents: Tetrahydrofuran
标题:Palladium Complex-Catalyzed Intermolecular Reductive N-Heterocyclization: Novel Synthesis Of Quinazoline Derivatives From 2-Nitrobenzaldehyde Or 2-Nitrophenyl Ketones With Formamide
作者:Akazome,Motohiro; Et Al
参考文献:Journal Of Organometallic Chemistry 日期:1995 卷标:494(1-2) 页码:229-33]

88-96-0 = 86-96-4
反应条件:1.1 Reagents: Iodobenzene Diacetate Solvents: Methanol; Rt
标题:Onsh: Optimization Of Oxidative Alkylamination Reactions Through Study Of The Reaction Mechanism
作者:Verbeeck,Stefan; Et Al
参考文献:Journal Of Organic Chemistry 日期:2010 卷标:75(15) 页码:5126-5133]

88-96-0 = 86-96-4
反应条件:1.1 Reagents: Iodobenzene Diacetate Solvents: Methanol
标题:Oxidative Cyclization Of Diamides By Phenyliodoso Acetate
作者:Beckwith,Athelstan L. J.; Et Al
参考文献:Australian Journal Of Chemistry 日期:1990 卷标:43(3) 页码:451-61]

24424-99-5 + 88-68-6 = 86-96-4
反应条件:1.1 Catalysts: 4-(Dimethylamino)Pyridine Solvents: Acetonitrile; 12 H,Rt
标题:Dmap-Catalyzed One-Pot Synthesis Of Quinazoline-2,4-Diones From 2-Aminobenzamides And Di-Tert-Butyl Dicarbonate
作者:Chen,Hui; Et Al
参考文献:Acs Omega 日期:2020 卷标:5(16) 页码:9614-9623]

118-48-9 = 86-96-4
反应条件:1.1 Reagents: Urea; Rt
标题:Synthesis And Analgesic Activity Of 6-Amino-2-Piperazinylquinazolines
作者:Kornylov,A. Yu.; Et Al
参考文献:Visnik Odes'Koho Natsional'Noho Universitetu 日期:2021 卷标:26(1) 页码:74-84]

118-48-9 = 86-96-4 [标题:Reaction Conditions
标题:Product Class 13: Quinazolines
作者:Kikelj,D.
参考文献:Science Of Synthesis 日期:2004 卷标:16 页码:573-749]

917-61-3 = 86-96-4
反应条件:1.1 Solvents: Acetic Acid,Water; 35 °C; 30 Min,35 °C1.2 Reagents: Sodium Hydroxide; Cooled; 12 H,Cooled1.3 Reagents: Sulfuric Acid Solvents: Water; Ph 7
标题:Synthesis,Spectroscopic Characterization And X-Ray Analysis Of 6-Nitroquinazoline-2,4(1H,3H)-Dione
作者:Kesternich,Viictor; Et Al
参考文献:Journal Of The Chilean Chemical Society 日期:2013 卷标:58(3) 页码:1817-1819]

31143-83-6 + 590-28-3 = 86-96-4
反应条件:1.1 Reagents: Acetic Acid Solvents: Polyethylene Glycol; 25 Min,50 - 60 °C
标题:Condensation Reaction Of Ethyl 4-Oxo-4H-Benzo[d][1,3]Oxazine-2-Carboxylates With Potassium Cyanate: 2,4(1H,3H)-Quinazolinediones Synthesis
作者:Nikpour,Farzad; Et Al
参考文献:Heterocycles 日期:2012 卷标:85(11) 页码:2745-2748]

88-68-6 = 86-96-4
反应条件:1.1 Catalysts: Iodine Solvents: 1-Butyl-3-Methylimidazolium Tetrafluoroborate; 45 Min,80 °C; 80 °C -> Rt
标题:Green Synthesis Of Quinazolinone Derivatives Catalyzed By Iodine In Ionic Liquid
作者:Wang,Shu-Liang; Et Al
参考文献:Synthetic Communications 日期:2012 卷标:42(3) 页码:341-349]

= 86-96-4
反应条件:1.1 Reagents: Sulfuric Acid,Potassium Peroxymonosulfate Sulfate (2Khso5.Khso4.K2So4) Solvents: Tetrahydrofuran; Rt -> 40 °C; Overnight,40 °C
标题:A Radical Approach For The Selective C-H Borylation Of Azines
作者:Kim,Ji Hye; Et Al
参考文献:Nature (London 日期:2021 卷标:595(7869) 页码:677-683

海关参考信息

2902200000-苯
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-11542269-B2
优先权日:2018-01-03
标题:Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHOI HYEONG-WOOK; FANG FRANCIS G
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods utilizing Prins reaction in the preparation of compounds that may be useful as intermediates in the synthesis of halichondrin macrolides and analogs thereof. The invention also provides compounds that may be useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-10913749-B2
优先权日:2015-05-07
标题 :Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-11136335-B2
优先权日:2016-06-30
标题:Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHASE CHARLES E; CHOI HYEONG-WOOK; ENDO ATSUSHI; FANG FRANCIS G; KIM DAE-SHIK
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.

专利号:US-6376667-B1
优先权日:1997-11-26
标题 :Solid phase synthesis of heterocycles
发明人：CASTELHANO ARLINDO L; SHAO HUI
权利人:OSI PHARM INC
摘要:Methods and compounds for the synthesis of heterocycles, including pyrimidine-2,4-diones, are disclosed. Also disclosed are solid supports useful for solid phase synthesis, and methods for making the solid supports.

专利号:US-5783698-A
优先权日:1996-01-23
标题:Chemical synthesis of 1,3-disubstituted quinazolinediones
发明人：SMITH ADRIAN LEONARD
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to a method for the synthesis of 1,3-disubstituted quinazolinedione derivatives which comprises: n (a) reacting a haloformate functionalized polystyrene resin with a substituted anthranilic acid derivative under conditions effective to form a urethane-linkage; n (b) reacting the product of step (a) with a primary amine under conditions effective to form an anthranilamide derivative; n (c) heating the anthranilamide to effect intramolecular cyclization thereby liberating the 1,3-disubstituted quinazolinedione derivative from the resin into solution; and n (d) isolating the 1,3-disubstituted quinazolinedione by filtration and solvent removal.

专利号:US-9315483-B2
优先权日:2007-09-13
标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
发明人：JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT
权利人:CONCERT PHARMACEUTICALS INC
摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.

其他信息查阅

常州市兰明科技有限公司

网址: http://www.lmkjcz.com
企业联系电话：0519-88816918👤
地址:江苏省常州市采菱路7号

⚠️ 未注册 · 未认证企业

备注: 📌 数据来源说明：本展台内容基于各搜索引擎等公开数据整理，仅作展示用途。请用户自行辨别
✉️ 若企业需抹除展台内容或有异议，请通过页面底部联系方式告知我们，我们会尽快处理。

上海蓝润化学有限公司

网址: http://www.longrunchem.com
企业联系电话：021-69515658;13701998368👤
地址:上海市青浦区重固镇赵重公路2278号5号楼4层C区34座

⚠️ 未注册 · 未认证企业

杭州优联医药化工公司

网址: http://www.unipharma-chem.com
企业联系电话：0571-85803833;56766020👤
地址:浙江省杭州市朝晖路203号深蓝广场办公楼1109室

⚠️ 未注册 · 未认证企业

济宁心和化工有限公司

网址: http://www.xinhechem.cn
企业联系电话：15318402391👤
地址:济宁市任城区中德广场A座1305

⚠️ 未注册 · 未认证企业

上海有朋化工有限公司

网址: http://www.youpengchem.com
企业联系电话：13701776567;021-69002118;69006118👤
地址:上海市嘉定区鹤旋路26弄22号512室

⚠️ 未注册 · 未认证企业

第 1 / 1 页

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献

摘要:Kang, F.-A.; Yang, S.-M., Science of Synthesis Knowledge Updates, (2015) 2, 209.
摘要:Sellars, J. D., Science of Synthesis Knowledge Updates, (2014) 1, 400.
摘要:Chimica Therapeutica., 3(100), 1968
摘要:A. Albert and J. N. Phillips. J. Chem. Soc. 1956, 1294.
摘要:J. Gut, M. Prystas, J. Jonas and F. Sorm, Collect. Czech. Chem. Commun. 26, 974 (1961).