CAS: 78941-93-2; 7-Chloro-8-Methylquinoline

该化合物是有机合成的多用途中间体,特别是在开发药品,农用化学品和特殊化学品方面,其结构特征提高了交叉反应的回动性和选择性,使其对构建复杂的热循环框架很有价值.该氯组有利于进一步功能化,而该组则有助于消毒和电子调节.由于高度纯度和稳定性, 7-Chloroo-8-甲基乙基诺ine 7-7-Chloroloro-8-Mecyquiquinoline 适合需要精确分子修改的研究和工业应用.其一贯性表现强调了其在先进的合成化学中的实用性.

结构式图片

相似化合物

63136-60-7 643039-79-6 1215205-97-2

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

CAS号78941-95-4 5-氯-8-甲基喹啉 | CAS号611-32-5 8-甲基喹啉 | CAS号7463-35-6 3-氯-2-甲基乙酰苯胺 | CAS号56-81-5 甘油 | CAS号84086-96-4 3,7-二氯-8-氯甲基喹啉 | CAS号84086-97-5 3,7-二氯-8-二氯甲基喹啉 | CAS号84163-79-1 8-(bromomethyl)...

合成工艺路线路线简述

  • 56-81-5 + 87-60-5 = 78941-93-2
    反应条件:1.1 Reagents: Sulfuric Acid Catalysts: Sodium Iodide Solvents: Water; 0.5 H,140 °C; 6 H,140 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 9 - 10
    标题:Rh(Iii)-Catalyzed Straightforward Arylation Of 8-Methyl/formylquinolines Using Diazo Compounds
    作者:Ghosh,Bidhan; Samanta,Rajarshi
    参考文献:Chemical Communications (Cambridge 日期:2019 卷标:55(48) 页码:6886-6889]

    611-32-5 = 78941-93-2
    反应条件:1.1 Reagents: Chlorine
    标题:Aromatic Chlorination And Iodination Of 8-Methylquinoline. Benzyl Bromination Of 5-Halo-8-Methylquinolines
    作者:Tochilkin,A. I.; Gracheva,I. N.; Kovel'Man,I. R.; Prokof'Ev,E. P.
    参考文献:Khimiya Geterotsiklicheskikh Soedinenii 日期:1983 卷标:(10) 页码:1373-6]

    56-81-5 + 87-60-5 = 78941-93-2
    反应条件:1.1 Reagents: Sulfuric Acid Catalysts: Sodium Iodide Solvents: Water; 0.5 H,140 °C; 3.5 H,140 - 145 °C; 145 °C -> Rt; Cooled1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 8 - 11,Cooled
    标题:Palladium-Catalyzed C(Sp3)-H Biarylation Of 8-Methyl Quinolines With Cyclic Diaryliodonium Salts To Access Functionalized Biaryls And Fluorene Derivatives
    作者:Maurya,Naveen Kumar; Yadav,Suman; Chaudhary,Dhananjay; Kumar,Dharmendra; Ishu,Km; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2022 卷标:87(21) 页码:13744-13749]

    56-81-5 + 87-60-5 = 78941-93-2
    反应条件:1.1 Reagents: Sulfuric Acid,Sodium Iodide Solvents: Water; 0.5 H,140 °C; 6 H,140 - 145 °C; 145 °C -> Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 8 - 11,Cooled
    标题:Rhiii-Catalyzed Direct Heteroarylation Of C(Sp3)-H And C(Sp2)-H Bonds In Heterocycles With N-Heteroaromatic Boronates
    作者:Wang,Huai-Wei; Wu,Jia-Xue; Qiao,Yu-Han; Li,Yong-Fei; Li,Da-Cheng; Et Al
    参考文献:Organic Letters 日期:2021 卷标:23(18) 页码:7177-7182]

    56-81-5 + 87-60-5 = 78941-93-2
    反应条件:1.1 Reagents: Sulfuric Acid,Sodium Iodide Solvents: Water; 0.5 H,140 °C; 6 H,140 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; Neutralized; Ph 9 - 10
    标题:Iodonium Ylides As Carbene Precursors In Rh(Iii)-Catalyzed C-H Activation
    作者:Jiang,Yuqin; Li,Pengfei; Zhao,Jie; Liu,Bingxian; Li,Xingwei
    参考文献:Organic Letters 日期:2020 卷标:22(19) 页码:7475-7479]

    87-60-5 = 78941-93-2 [标题:Reaction Conditions
    标题:Product Class 3: Quinolines
    作者:Larsen,R. D.; Cai,D.
    参考文献:Science Of Synthesis 日期:2005 卷标:15 页码:389-549]

    87-60-5 = 78941-93-2
    反应条件:1.1 Reagents: Sulfuric Acid Catalysts: Potassium Iodide Solvents: Water; 90 Min; 2 H,140 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 7 - 8
    标题:Synthesis Of High-Activity Weedicide Quinclorac And Qsar Analysis
    作者:Yang,Lei; Wang,Peng; Zhou,De-Rui
    参考文献:Journal Of Harbin Institute Of Technology (English Edition) 日期:2002 卷标:9(4) 页码:401-404]

    56-81-5 + 87-60-5 = 78941-93-2
    反应条件:1.1 1 H,160 °C; 160 °C -> 100 °C1.2 Reagents: Sodium Iodide; 100 °C -> 150 °C1.3 Reagents: Sulfuric Acid; 150 °C; 1 H,150 °C
    标题:Palladium-Catalyzed Chelation-Assisted Aldehyde C-H Bond Activation Of Quinoline-8-Carbaldehydes: Synthesis Of Amides From Aldehydes With Anilines And Other Amines
    作者:Thakur,Dinesh Gopichand; Rathod,Nileshkumar B.; Patel,Sachinkumar D.; Patel,Dharmik M.; Patel,Raj N.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2024 卷标:89(2) 页码:1058-1063]

    56-81-5 + 87-60-5 = 78941-93-2
    反应条件:1.1 Reagents: Sulfuric Acid Catalysts: Sodium Iodide; 0.5 H,Rt; Rt -> 140 °C; 3 H,140 °C; 1 H,140 °C -> 160 °C; 160 °C -> Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 9 - 10,Rt
    标题:Palladium-Catalyzed Directed Aldehyde C-H Arylation Of Quinoline-8-Carbaldehydes: Exploring The Reactivity Differences Between Aryl (Pseudo) Halides
    作者:Thakur,Dinesh Gopichand; Sahoo,Tapan; Sen,Chiranjit; Rathod,Nilesh; Ghosh,Subhash Chandra
    参考文献:Journal Of Organic Chemistry 日期:2022 卷标:87(24) 页码:16343-16350]

    87-60-5 = 78941-93-2
    反应条件:1.1 Reagents: Potassium Iodide,Potassium Persulfate,Oxygen Catalysts: Silver Carbonate Solvents: Diethylformamide; Rt -> 120 °C; 12 H,120 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; Neutralized
    标题:From Anilines To Quinolines: Iodide- And Silver-Mediated Aerobic Double C-H Oxidative Annulation-Aromatization
    作者:Wu,Jiwei; Liao,Zhixiong; Liu,Dong; Chiang,Chien-Wei; Li,Zheng; Et Al
    参考文献:Chemistry - A European Journal 日期:2017 卷标:23(63) 页码:15874-15878]

    56-81-5 + 87-60-5 = 78941-93-2
    反应条件:1.1 Reagents: Sulfuric Acid Catalysts: Sodium Iodide Solvents: Water; 0.5 H,140 °C; 3.5 H,140 - 145 °C; 145 °C -> Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 8 - 11,Cooled
    标题:Rh-Catalyzed Direct Amination Of Unactivated C(Sp3)-H Bond With Anthranils Under Mild Conditions
    作者:Tang,Conghui; Zou,Miancheng; Liu,Jianzhong; Wen,Xiaojin; Sun,Xiang; Et Al
    参考文献:Chemistry - A European Journal 日期:2016 卷标:22(32) 页码:11165-11169]

    56-81-5 + 87-60-5 = 78941-93-2
    反应条件:1.1 Reagents: Sulfuric Acid,Sodium Iodide Solvents: Water; 0.5 H,140 °C; 3.5 H,140 - 145 °C; 145 °C -> Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 8 - 11,Cooled
    标题:Rhodium(Iii)-Catalyzed Intermolecular Amidation With Azides Via C(Sp3)-H Functionalization
    作者:Wang,Nuancheng; Li,Renhe; Li,Liubo; Xu,Shansheng; Song,Haibin; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2014 卷标:79(11) 页码:5379-5385
📜8-甲基喹啉置于silver Sulfate 氯体系中,用 硫酸 作为反应溶剂,化学反应 56.0H,反应生成 7-氯-8-甲基喹啉
参考文献:8-甲基喹啉的芳族氯化和碘化.5-卤代8-甲基喹啉的苄基溴化
标题:8-甲基喹啉的芳族氯化和碘化.5-卤代8-甲基喹啉的苄基溴化
摘要:
DOI:10.1007/bf00505763

海关参考信息

专利信息


专利号:CN-108290134-A
优先权日:2015-11-27
标 题 :Ultrafast high-yield synthesis of metal-organic frameworks

专利号:CN-109173602-B
优先权日:2018-07-25
标题:A kind of recycling method of nitrogen oxide waste gas produced in quinclorac acid synthesis

专利号:CN-116969887-B
优先权日:2023-09-25
标题 :Preparation process of intermediate 7-chloro-8-quinolinic acid and synthesis process of quinclorac

专利号:CN-116969887-A
优先权日:2023-09-25
标题 :Preparation process of intermediate 7-chloro8-quinolinic acid and synthesis process of quinclorac

专利号:CN-107721920-B
优先权日:2017-10-30
标题:Synthesis method of quinoline amide compound

专利号:CN-101851197-B
优先权日:2010-06-07
标 题:Synthesis and purification method of quinclorac

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合成参考文献


摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 80.
摘要:Sharma, U.; Parmar, D.; Sumit; Manisha, Science of Synthesis: Knowledge Updates, (2024) 2, 130.
摘要:Sharma, U.; Parmar, D.; Sumit; Manisha, Science of Synthesis: Knowledge Updates, (2024) 2, 164.
摘要:Sharma, U.; Parmar, D.; Sumit; Manisha, Science of Synthesis: Knowledge Updates, (2024) 2, 145.
摘要:Sharma, U.; Parmar, D.; Sumit; Manisha, Science of Synthesis: Knowledge Updates, (2024) 2, 176.
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