CAS: 77868-40-7; N1,N3-Bis(2,3-Dihydroxypropyl)-5-(2-Hydroxyacetamido)-2,4,6-Triiodoisophthalamide

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CAS号87771-40-2 碘氟醇

5-氨基-2,4,6-三碘间苯二甲酸置于氯化亚砜,水,Sodium Hydroxide体系中,用 N,N-二甲基乙酰胺 作为反应溶剂,化学反应 23.5H,反应生成 N,N'-二(2,3-二羟基丙基)-5-[(羟基乙酰基)氨基]-2,4,6-三碘-1,3-苯二甲酰胺
参考文献:Process For The Monotopic Preparation Of Intermediate Organo-Iodinated Compounds For The Synthesis Of Ioversol
标题:Process For The Monotopic Preparation Of Intermediate Organo-Iodinated Compounds For The Synthesis Of Ioversol
摘要:该发明涉及一种制备有机碘化合物及其制备中间体的过程.更具体地说,该发明涉及一种制备有机碘化合物的过程,该化合物在对比剂ioversol的合成中起到制备中间体的作用.

专利信息

专利号:US-5489708-A
优先权日:1992-05-15
标题 :Synthesis of ioversol
发明人：BAILEY ALLAN R; SATHE SHARAD S; SPEARS ANDRE T; WISNESKI RICHARD C; KNELLER MILLS T
权利人:MALLINCKRODT MEDICAL INC
摘要:The reduction of the O-alkyl isomer content of 5-[N-(2-acetoxyethyl)acetoxyacetamido]-N,N'-bis(2,3-diacetoxypropyl)-2,4,6-triiodoisophthalamide to thereby reduce and/or eliminate the production of impurities comparatively more difficult to remove during the purification of crude ioversol.

专利号:WO-2020025787-A1
优先权日:2018-08-02
标 题 :Process for the monotopic preparation of intermediate organo-iodinated compounds for the synthesis of ioversol

专利号:US-4352788-A
优先权日:1979-08-09
标题 :Derivatives of 2,4,6-triiodo-isophthalic acid, processes for their synthesis and X-ray contrasting materials containing these
发明人：FELDER ERNST; PITRE DAVIDE
权利人:BRACCO IND CHIMICA SPA
摘要:Compounds for use in non-ionic X-ray contrasting materials having the formula ##STR1## in which (H0) 2-3 alkyl is 1,3-dihydroxyisopropyl, 2,3-dihydroxypropyl or 1,3-dihydroxy-2-hydroxymethylisopropyl, n R is hydrogen or methyl, and n R 1 is an alkyl residue with 1 to 5 carbon atoms. n These compounds possess high water-solubility as well as excellent stability against hydrolysis. Methods for preparation and use of the compounds are also disclosed.

专利号:US-4348377-A
优先权日:1979-08-09
标题:New derivatives of 2,4,6-triiodo-isophthalic acid, proceses for their synthesis and X-ray contrasting materials containing these
发明人：FELDER ERNST; PITRE DAVIDE
权利人:BRACCO IND CHIMICA SPA
摘要:Novel, radio-opaque compounds comprising water-soluble bis-[N-{3,5-bis-(hydroxyalkylaminocarbonyl)-2,4,6-triiodo-phenyl}-N-( alpha -hydroxyacyl)-amino]-alkanes are disclosed for use as X-ray contrast agents. These compounds are relatively simple to synthesize, possess low toxicity and have good stability as well as resistance to hydrolysis. Methods for preparation and use of the compounds are also disclosed.

专利号:US-2021284597-A1
优先权日:2018-08-02
标 题:Process for the Monotopic Preparation of Intermediate Organo-Iodinated Compounds for the Synthesis of Ioversol

专利号:WO-9323365-A1
优先权日:1992-05-15
标 题:Improved synthesis of ioversol