CAS: 760207-87-2; 5-Bromo-2-Methoxy-3-Methylpyridine

该化合物是一种环环环的杂交有机化合物,其特点是有六人组成的芳香环,含有一个氮原子;5号位置有溴原子,2号位置有一个混合氧组(OCH3),3号位置的甲基组(-CH3)有助于其独特的化学特性;该化合物一般无色,不光黄色液体或固体,取决于其在室内温度的物理状态;它溶于乙醇和二氯甲烷等有机溶剂,但由于其水上恐惧性特征,在水中溶解性可能有限;溴亚化物的亚化能可增强其再活动,使其在各种化学反应中有用,包括核分裂替代和混合反应;此外,甲氧和甲基组可影响其电子特性和阻力,影响其在生物系统和合成应用中的行为;总体而言,5-Bromo-2-methoxy-3-甲基丙胺对医药化学和材料科学的潜在应用感兴趣.

英文名称5-Bromo-2-Methoxy-3-Methylpyridine
中文名称5-溴-2-甲氧基-3-甲基吡啶
IUPAC名称5-bromo-2-methoxy-3-methylpyridine
其它别名2-甲氧基-3-甲基-5-溴吡啶; 2甲氧基5溴3甲基吡啶; 5-Bromo-3-Methyl-2-Methoxypyridine; 5-Bromo-2-Methoxy-3-Methylpyridine
CAS编号760207-87-2
MFCD编号:MFCD07375124
EINECS号:676-882-1
分子式:C7H8BrNO
分子量:202.05
产品CID: 1752250
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: RHYCFMXPPGZHAW-UHFFFAOYSA-N
InChI=1S/C7H8BrNO/c1-5-3-6(8)4-9-7(5)10-2/h3-4H,1-2H3…
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数1.0

相似化合物

1227516-75-7 941294-54-8 1254123-51-7

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
皮肤腐蚀/刺激类别2
严重眼刺激类别2
警示词Warning(警告)
危险描述H302 |吞咽有害.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xi
安全声明26-37

欧盟法规

C&L通报

上下游产品

合成工艺路线路线简述

2-氨基-3-甲基-5-溴吡啶置于硫酸,Silver Carbonate,Sodium Nitrite体系中,用二氯甲烷,水作为反应溶剂,化学反应生成 5-溴-2-甲氧基-3-甲基吡啶
参考文献:Inhibition Of Hiv-1 Capsid Assembly: Optimization Of The Antiviral Potency By Site Selective Modifications At N1,C2 And C16 Of A 5-(5-Furan-2-Yl-Pyrazol-1-yl)-1H-Benzimidazole Scaffold
标题:Inhibition Of Hiv-1 Capsid Assembly: Optimization Of The Antiviral Potency By Site Selective Modifications At N1,C2 And C16 Of A 5-(5-Furan-2-Yl-Pyrazol-1-yl)-1H-Benzimidazole Scaffold
摘要:A Uhts Campaign Led To The Discovery Of A 5-(5-Furan-2-Ylpyrazol-1-yl)-1H-Benzimidazole Series That Inhibits Assembly Of Hiv-1 Capsid. Synthetic Manipulations At N1,C2 And C16 Positions Improved The Antiviral Potency By A Factor Of 1000. The X-Ray Structure Of 33 Complexed With The Capsid N-Terminal Domain Allowed Identification Of Major Interactions Between The Inhibitor And The Protein. (C) 2012 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2012.10.034

海关参考信息

2905110000-甲醇
2933310010-吡啶
2909199090-其他醚及其衍生物
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

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优先权日:2013-07-17
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发明人：SHIRUDE PRAVIN S; NAIK MARUTI N; SHINDE VIKAS NARAYAN; PEER MOHAMED SHAHUL HAMEED; CHATTERJI MONALISA; SHINDIL RADHA K
权利人:GLOBAL ALLIANCE FOR TB DRUG DEV; ASTRAZENECA AB; FOUNDATION FOR NEGLECTED DISEASE RES
摘要:The invention provides compounds of formula (I) and methods of treating a Mycobacterium infection or tuberculosis, or inhibiting DprE1 with the same.

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专利号:CN-105636646-A
优先权日:2013-07-17
标题 :Azaindole compounds, their synthesis and methods of use