专利号:US-2023286918-A1 优先权日:2020-07-02 标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat 发明人:JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER 权利人:AKEBIA THERAPEUTICS INC 摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.
专利号:US-12435086-B2 优先权日:2020-04-29 标题:Synthesis of heterocyclic compounds 发明人:LIN JACK; WALTERS JASON 权利人:PLEXXIKON INC 摘要:Provided herein are intermediates and processes useful for facile synthesis of compounds of Formula 2:wherein R1 is C(O)R2; R2 is alkyl optionally substituted with 1-5 halogens; G is phenyl or a 5-6 membered heteroaryl optionally substituted with 1-2 R3; and each R3 is independently C1-C6 alkyl, CN, C1-C6 alkyl-CN, 3-6 membered cycloalkyl, or 4-6 membered heterocycloalkyl.
专利号:US-4022672-A 优先权日:1976-04-02 标题:Electrochemical synthesis of insecticide intermediates 发明人:ALVAREZ MANUEL; FISHMAN MORRIS L 权利人:FMC CORP 摘要:1,1,1-Trihalo-4-methylpentenes, carrying 2-substituents selected from those conjugate bases of Bronsted acids which are leaving groups in beta eliminations, are reduced electrochemically to 1,1-dihalo-4-methylpentadienes, intermediates in the synthesis of pyrethroid insecticides.
专利号:US-9267213-B1 优先权日:2005-03-25 标题:Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array 发明人:MAURER KARL; COOPER JOHN J 权利人:CUSTOMARRAY INC 摘要:There is disclosed an electrochemical deblocking solution for use on an electrode microarray. There is further disclosed a method for electrochemical synthesis on an electrode array using the electrochemical deblocking solution. The solution and method are for removing acid-labile protecting groups for synthesis of oligonucleotides, peptides, small molecules, or polymers on a microarray of electrodes while substantially improving isolation of deblocking to active electrodes. The method comprises applying a voltage or a current to at least one electrode of an array of electrodes. The array of electrodes is covered by the electrochemical deblocking solution.
专利号:US-4138418-A 优先权日:1977-03-08 标题:Process for the preparation of ω,ω-dialkoxycarboxylic acid derivatives 发明人:WARNING KLAUS; MITZLAFF MICHAEL 权利人:HOECHST AG 摘要:ω,ω-Dialkoxycarboxylic acid derivatives I (amides and esters) are prepared by heating ω-alkoxylactams II with hydrogen halide in an alcohol. When using only a catalytical quantity of hydrogen halide, there are obtained the amides, when using a quantity of hydrogen halide which is at least about equimolar, there are obtained the esters of the corresponding ω,ω-dialkoxycarboxylic acids. Since the compounds I are acetals, they may be readily converted into the corresponding ω-formyl compounds. Both the acetals I and the corresponding ω-formyl compounds are valuable intermediates for the synthesis of for example prostaglandins, sexual attractants and antioxidants.
专利号:US-11518726-B2 优先权日:2017-10-11 标题 :Synthesis of bicyclo[2.2.2]octane derivatives 发明人:HU YUE RACHEL; HEMBRE ROBERT THOMAS; TUSTIN GERALD CHARLES; LIU ZHUFANG; ADAMS STEVEN J 权利人:EASTMAN CHEM CO 摘要:Provided is a process for the preparation of certain 1,4-bicyclo[2.2.2]octane derivatives. The new synthetic procedure involves treating 1,4-dimethylene cyclohexane with an oxidizing agent in the presence of a transition metal catalyst to afford an oxo-substituted bicyclo[2.2.2]octane species. This intermediate structure can then be further derivatized. The processes of this disclosure thus affords a novel and simplified means for the commercial production of a wide variety of bicyclo[2.2.2]octane derivatives.
摘要:Santana, V. C. S.; Munaretto, L. S.; de Lucca, E. C., Jr., Science of Synthesis Knowledge Updates, (2022) 1, 208. 摘要:Hou, Z.-W.; Xu, H.-C., Science of Synthesis: Special Topics, (2021) 1, 185. 摘要:Selt, M.; Waldvogel, S. R., Science of Synthesis: Special Topics, (2021) 1, 258. 摘要:Folgueiras-Amador, A. A.; Hodgson, J. W.; Brown, R. C. D., Science of Synthesis: Special Topics, (2021) 1, 421. 摘要:Lam, K.; Leech, M. C.; Lennox, A. J. J., Science of Synthesis: Special Topics, (2021) 1, 444.