6-氯-2,4-二硝基苯酚置于ammonium Sulfide体系中,化学反应生成 2-氨基-6-氯-4-硝基苯酚 参考文献:Human Osteoclast Cathepsin K Is Processed Intracellularly Prior To Attachment And Bone Resorption 标题:Human Osteoclast Cathepsin K Is Processed Intracellularly Prior To Attachment And Bone Resorption 摘要:猫肽酶k是半胱氨酸蛋白酶香肠酶超家族的一个成员,并被提议在破骨细胞介导的骨吸收中发挥关键作用.我们开发了一种灵敏的细胞化学检测法,以定位和量化破骨细胞猫肽酶k在破骨细胞瘤和人类骨组织切片中的活性.在组织切片中,远离骨组织的破骨细胞表现出高水平的猫肽酶k信使rna(mrna)和蛋白质.然而,这些细胞中的大部分猫肽酶k处于不活跃的酶原形式,使用细胞化学检测和特异性免疫染色进行评估.相反,靠近骨组织的破骨细胞含有高水平的免疫反应性成熟猫肽酶k,其酶活性以极性方式与骨表面共分布.在靠近骨组织的破骨细胞中,活性酶的极性显而易见.与骨表面接触的破骨细胞几乎完全表达成熟形式的猫肽酶k.这些细胞显示出强烈的酶活性,且在皱褶边界处极化.这些结果表明,猫肽酶k的体内激活是在细胞内发生的,在分泌到吸收凹陷和骨吸收开始之前.促猫肽酶k转化为成熟猫肽酶k的过程发生在破骨细胞接近骨组织时,这表明局部因素可能会调节这一过程. DOI:10.1359/jbmr.2001.16.3.478
专利号:EP-4206236-A1 优先权日:2021-12-28 标题 :Compounds, their synthesis and compositions comprising the compounds for enhanced deposition of polymers onto hair surfaces 发明人:BREAKSPEAR STEVEN; NÖCKER BERND; WEITZEL JOHANNA; PAEZ JULIETA; PEARSON SAMUEL; BRÜCK STEFAN; CAMPO ARANZAZU DEL 权利人:KAO CORP 摘要:The present invention is on polymers derivatized with an organic deposition-enhancing group for their enhanced deposition onto keratin fibers, especially human hair. The deposition-enhancing group is a di-hydroxyl phenolic compound with a spacer alkyl group bound to a reactive amine or carboxyl group, which reacts with one of the hydroxyl, carboxyl, primary and secondary amine groups on the polymeric backbone. The invention is on the method of synthesizing such compounds and compositions comprising the compounds.
专利号:WO-2008028776-A1 优先权日:2006-09-06 标题 :Agents containing bioquinones and specific emulsifiers 发明人:SCHULZE ZUR WIESCHE ERIK; SCHEUNEMANN VOLKER; POPPE ELISABETH; WELSS THOMAS; GIESEN MELANIE 权利人:HENKEL KGAA; SCHULZE ZUR WIESCHE ERIK; SCHEUNEMANN VOLKER; POPPE ELISABETH; WELSS THOMAS; GIESEN MELANIE 摘要:The invention relates to cosmetic agents, in particular hair treatment agents, containing at least one specific emulsifier and at least one bioquinone. Treating the hair with said agents activates the keratin synthesis of hair keratin that declines with age.
专利号:US-8445651-B2 优先权日:2008-10-23 标题 :Method for producing charge control agent and toner 发明人:ZHU SHUNQUAN; WANG YUBIN 权利人:ZHU SHUNQUAN; WANG YUBIN; HUBEI DINGLONG CHEMICAL CO LTD 摘要:The invention discloses a method for producing a charge control agent and a toner containing the charge control agent. The preparation method includes the technical proposal that in aqueous medium, an azo compound is reacted with a salicylic acid chromium complex, which is used as a complexing agent to synthesize a specific azo chromium complex. The preparation method is characterized by complex synthesis engineering. The toner of the invention includes a charge control agent obtained from the method described herein. Provided is a method for obtaining a charge control agent and a toner with excellent chargeability in that no flying or fogging is observed, even during image formation at high printing speeds. The toner is relatively free from the influences of variations in the environmental temperature and humidity, which ensures stable image printing with high picture quality for long periods of time.
专利号:US-6570019-B2 优先权日:2000-02-25 标 题:Cationic pyrrolo-pyrrol-derivatives, method for producing them and colorants for keratin fibers, containing these compounds 发明人:PASQUIER CECILE; WYSS PATRICK; BRAUN HANS-JUERGEN 权利人:WELLA AG 摘要:The object of the present invention are diketopyrrolopyrroles of the general formula (I)wherein, independently of one another, Q1 and Q2 represent an optionally substituted, aromatic, isocyclic or heterocyclic group with 5 to 14 atoms in the ring, the heterocyclic group containing at least one oxygen, nitrogen or sulfur atom, and the R1 and R2 groups, independently of one another represent hydrogen or a Y-B+A- group, with the proviso that at least one of the R1 and R2 groups is not hydrogen; B+ is an aromatic, aliphatic, alicyclic, aromatic heterocyclic or non-aromatic heterocyclic, quaternary ammonium group or a quaternary phosphonium group; Y is an optionally substituted linear or branched C1 to C6 alkylene group and A- is an anion; a method for their synthesis as well as agents, containing compounds of formula (I), for dyeing keratin fibers.
专利号:CN-119241459-A 优先权日:2024-09-03 标题:Benzo (A) benzo (B) benzo (A oxazole/benzo Synthesis method of thiazole compound