专利号:US-3943142-A 优先权日:1969-01-24 标 题:Dye intermediates and their preparation and use in the synthesis of methine dyes 发明人:OWEN JOHN R 权利人:EASTMAN KODAK CO 摘要:Compositions of matter are provided comprising a stable, non-vaporous monomeric methylene base selected from a 2-methylenethiazoline; a 2-methylenebenzothiazoline; a 2-methylenenaphthothiazoline; a 2-methylenebenzoselenazoline; and a 2-methylenenaphthoselenazoline. The compositions of the invention are prepared by reacting the parent 2-methyl quaternary salt with a non-hydroxylic base which removes a proton of the heterocyclic salt together with a proton acceptor which inhibits build-up of the hydro salt of the non-hydroxylic base, the reaction being conducted under anhydrous conditions in a non-hydroxylic liquid in which the heterocyclic quaternary salt is sufficiently insoluble to inhibit dimer formation. The compositions of the invention are employed in the preparation of methine dyes.
专利号:US-5656634-A 优先权日:1991-03-21 标题 :N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) 发明人:CHANG GEORGE; HAMANAKA ERNEST S; MCCARTHY PETER A; TRUONG THIEN V; WALKER FREDERICK J 权利人:PFIZER 摘要:Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R 1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.
专利号:CN-107162968-B 优先权日:2017-05-25 标 题 :A kind of method of visible light catalytic Tetrahydroquinolinesas oxidative dehydrogenation synthesis of quinoline class compound
专利号:US-5596001-A 优先权日:1993-10-25 标题 :4-aryl-3-(heteroarylureido)quinoline derivatves 发明人:HAMANAKA ERNEST S 权利人:PFIZER 摘要:Compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , m, X and Q are as defined below, and novel intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and natiatherosclerosis agents.
专利号:US-4618686-A 优先权日:1984-09-27 标 题 :Process for dehalogenation of aryl and alpha-araliphatic halides 发明人:BOYER STEPHEN K 权利人:CIBA GEIGY CORP 摘要:Process for the dehalogenation of aryl and alpha-araliphatic halides comprising contacting the aryl halide or alpha-araliphatic halide with hypophosphite salt, in the presence of a catalytic amount of a noble metal catalyst. This process is useful in the field of organic synthesis and for the removal of environmentally hazardous aryl and alpha-araliphatic halides, including polychlorinated biphenyls and dibenzo-p-dioxins.
专利号:CN-108503582-A 优先权日:2018-01-19 标 题:Microwave Assisted Synthesis of 2-(1H)-Quinolinones
[参考文献]: Tsuyoshi Tagata, Et Al. Palladium Charcoal-Catalyzed Suzuki-Miyaura Coupling To Obtain Arylpyridines And Arylquinolines. J Org Chem. 2003 Nov 28;68(24):9412-5.
合成参考文献
摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 89. 摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 310. 摘要:Gleason, J. L.; Tiong, E. A., Science of Synthesis Knowledge Updates, (2010) 4, 287. 摘要:Bergin, E., Science of Synthesis: Stereoselective Synthesis, (2011) 2, 567. 摘要:Sandrock, D. L., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 341.