CAS: 485-64-3; (R)-((1S,2S,4S,5R)-5-Ethylquinuclidin-2-yl)(Quinolin-4-yl)Methanol

相似化合物

485-65-4 5962-19-6 118-10-5

上下游产品

CAS号486-74-8 4-喹啉羧酸 | CAS号491-35-0 4-甲基喹啉 | CAS号612-11-3 3,4-二乙吡啶

📜辛可尼丁置于palladium On Activated Charcoal 氢气体系中,用 甲醇 作为反应溶剂,化学反应 12.0H,以86%的收率获得产物(8Alpha,9R)-10,11-二氢脱氧辛可宁-9-醇
参考文献:相转移催化的不对称酰基咪唑烷基化.
标题:相转移催化的不对称酰基咪唑烷基化.
摘要:在2-辛基吡啶鎓催化剂的相转移条件下,将2-酰基咪唑与烯丙基和苄基亲电子试剂在-40oc下以高收率和优异的对映选择性(79至> 99%ee)烷基化.酰基咪唑底物由溴乙酸经n-酰基吗啉加合物分三步制备.该催化剂以高纯度制备,可在温和条件下形成s产物(6-20小时),这与离子对机理相符.使用三氟甲磺酸甲酯和甲醇钠,经由二甲基酰基咪唑鎓中间体容易地将产物转化为有用的酯产物,而没有外消旋作用.该过程是有效的,直接的,并且适合于通过烯醇化中间体进行的其他亲电试剂和转化.
DOI:10.1021/ol702197R

专利信息

专利号:US-9126995-B2
优先权日:2011-11-08
标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound
发明人：TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU
权利人:NISSAN CHEMICAL IND LTD
摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.

专利号:US-9593071-B2
优先权日:2011-11-22
标题 :Process for the preparation of gamma amino acids and intermediates used in said process
发明人：ADAMO MAURO
权利人:ROYAL COLLEGE SURGEONS IRELAND
摘要:The invention relates to the preparation of gamma amino acids of formula (I) and pharmaceutically acceptable salts, solvates and prodrugs thereof, and to intermediates used for their preparation. (formula I) wherein R 1 is selected from an alkyl group, an alkenyl group, an alkynyl group and a cycloalkyl group, each of which may be optionally substituted and * denotes a chiral center. In particular, the present invention provides an efficient synthesis of (S)-pregabalin which is suitable for carrying out on an industrial scale.

专利号:US-2014350261-A1
优先权日:2011-11-08
标 题 :Method for catalytic asymmetric synthesis of optically active isoxazoline compound, and optically active isoxazoline compound

专利号:WO-2011138625-A1
优先权日:2010-05-07
标题 :Industrial process for the synthesis of ivabradine salts

专利号:WO-2013069731-A1
优先权日:2011-11-08
标题 :Method for catalytic asymmetric synthesis of optically active isoxazoline compound, and optically active isoxazoline compound

专利号:NL-9100854-A
优先权日:1990-05-17
标 题 :METHOD FOR PREPARING INTERMEDIATES USE FOR THE SYNTHESIS OF BENZODIAZEPINES.