CAS: 480451-98-7; Tert-Butyl (1R,2R,5S)-2-({2-[(5-Chloropyridin-2-yl)Amino]-2-Oxoacetyl}Amino)-5-[(Dimethylamino)Carbonyl]Cyclohexylcarbamate

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(1S,3S,6R)-7-oxabicyclo[4.1.0]heptane-3-carboxylic acid ethyl ester (1S)-3-cyclohexenecarboxylic acid 1,2,5,6-tetrahydrobenzoic acid 2-((5-chloropyridin-2-yl)amino)-2-oxoacetic acidtert-Butyl (1R,2S,5S)-2-{[3-(4-chlorophenyl)-3-oxopropanoyl]amino}-5-[(dimethylamino)carbonyl]-cyclohexylcarbamate 1-(5-chloropyridin-2-yl)-N2-{(1R,2R,4S)-4-(dimethylamin°Carbonyl)-2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carboxamido]cyclohexyl}oxalamide p-toluenesulfonic acidN1-(5-chloropyridin-2-yl)-N2-{(1R,2R,4S)-4-(dimethylamin°Carbonyl)-2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carboxamido]cyclohexyl}oxalamide p-toluenesulfonic acid

📜3-环己烯-1-甲酸置于ammonium Hydroxide,Sodium Azide,Lithium Hydroxide Monohydrate,Palladium On Activated Charcoal,碘,甲酸铵,三乙胺,Potassium Iodide,Sodium Hydroxide体系中,用 四氢呋喃,乙醇,二氯甲烷,水,N,N-二甲基甲酰胺,丙酮 作为反应溶剂,化学反应 129.0H,反应生成 依度沙班杂质11
参考文献:甲苯磺酸艾多沙班及其异构体的制备方法
标题:甲苯磺酸艾多沙班及其异构体的制备方法
摘要:本发明公开了一种甲苯磺酸艾多沙班及其异构体的制备方法,以化合物(I)和化合物(II)为起始原料,可用于制备高纯度的甲苯磺酸艾多沙班(1S,2R,4S),甲苯磺酸艾多沙班对映异构体(1R,2S,4R),甲苯磺酸伊多沙班差向异构体(1R,2R,4S)和甲苯磺酸伊多沙班差向异构体(1S,2S,4R)中任意一种物质,为甲苯磺酸艾多沙班原料药及相关制剂的工艺研究和质量控制提供了有效的保障,且该制备方法适合商业化,生产的甲苯磺酸艾多沙班原料药纯度高,具有重大的意义与实用的价值,有利于甲苯磺酸艾多沙班的原料药生产和药品质量控制.