CAS: 4786-61-2; 2-Methoxy-4,6-Dimethylpyrimidine-5-Carboxylic Acid

相似化合物

1823338-21-1 544704-06-5 548773-11-1

上下游产品

CAS号548773-11-1 2-甲氧基-4,6-二甲基嘧啶... | CAS号91179-57-6 Butanoic acid, ... | CAS号603-69-0 二乙酰乙酸乙酯 | CAS号544704-01-0 2-bromo-6-[(3-f... | CAS号544704-06-5 2-甲氧基-4,6-二甲基嘧啶...

📜2-Bromo-6-[(3-Fluoro-4-Methoxybenzoyl)Amino]-4-Methoxyphenyl-3-Fluoro-4-Methoxybenzoate置于acidic Solution,Sodium Ethanolate体系中,用 乙醇 作为反应溶剂,化学反应生成 2-甲氧基-4,6-二甲基嘧啶-5-甲酸
参考文献:Piperazine-Based Ccr5 Antagonists As Hiv-1 Inhibitors. Iii: Synthesis,Antiviral And Pharmacokinetic Profiles Of Symmetrical Heteroaryl Carboxamides
标题:Piperazine-Based Ccr5 Antagonists As Hiv-1 Inhibitors. Iii: Synthesis,Antiviral And Pharmacokinetic Profiles Of Symmetrical Heteroaryl Carboxamides
摘要:The Unsymmetrical Nicotinamide-N-Oxide Moiety In Compound I Was Replaced With Symmetrical Isonicotinamides As Well As 4,6-Dimethyl Pyrimidine-5-Carboxamides. Compound 16 From The Latter Set Reduced The Number Of Rotamers,Improved Potency Of Inhibiting Uiv Entry,Slightly Diminished The Affinity For The Muscarine Receptors And Showed Very Good Oral Absorption. (C) 2002 Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0960-894X(02)00918-6