CAS: 4740-78-7; 1,3-Dioxan-5-Ol

相似化合物

3391-30-8 505-22-6 39239-93-5

上下游产品

CAS号41128-92-1 O-benzyl-1,3-di... | CAS号49784-60-3 1,3-dioxan-5-yl... | CAS号50-00-0 甲醛 | CAS号56-81-5 甘油 | CAS号109-87-5 甲缩醛 | CAS号7647-01-0 盐酸 | CAS号7664-93-9 硫酸 | CAS号98-59-9 对甲苯磺酰氯(PTSC) | CAS号110-88-3 三聚甲醛 | CAS号32061-16-8 Benzenesulfonic... | CAS号87683-81-6 1,3-dioxan-5-one | CAS号49784-60-3 1,3-dioxan-5-yl... | CAS号51953-54-9 5-chloro-1,3-dioxane

O-Benzyl-1,3-Dioxan-5-Ol置于palladium 10% On Activated Carbon,氢气体系中,用 乙酸乙酯 作为反应溶剂,化学反应 12.0H,反应生成 甘油缩甲醛
参考文献:柔性环醚/聚醚作为 Hiv-1 蛋白酶抑制剂的新型 P2 配体:设计,合成,生物学评估和蛋白质配体 X 射线研究.
标题:柔性环醚/聚醚作为 Hiv-1 蛋白酶抑制剂的新型 P2 配体:设计,合成,生物学评估和蛋白质配体 X 射线研究.
摘要:我们报告了一系列新型 Hiv-1 蛋白酶抑制剂的设计,合成和生物学评估.抑制剂包含立体化学定义的柔性环醚/聚醚作为高亲和力 P2 配体.含有小环 1,3-二氧杂环烷烃的抑制剂已显示出有效的酶抑制和抗病毒活性.抑制剂 3D 和 3H 是活性最强的抑制剂.inhibitor 3D 对多种多重 Pi 抗性临床菌株保持出色的效力.我们的构效研究表明,环的大小,立体化学和氧的位置对观测到的活性很重要.已经描述了 1,3-Dioxepan-5-Ol 的光学活性合成以及各种环醚和聚醚配体的合成.确定了 3D 结合的 Hiv-1 蛋白酶的蛋白质配体 X 射线晶体结构.该结构表明,P2-配体进行广泛的相互作用,包括与 S2 位点中的蛋白酶骨架形成氢键.此外,3D 中的 P2-配体与 Gly-48 的 Nh 形成独特的水介导的相互作用.
DOI:10.1021/jm8004543

专利信息

专利号:US-2010099894-A1
优先权日:2006-10-09
标 题 :Method for the Synthesis of Cyclic Acetals by the Reactive Extraction of a Polyol in a Concentrated Solution
发明人：DUBOIS JEAN-LUC; IBORRA CHORNET SARA; VELTY ALEXANDRA I LUCIENNE; CORMA CANOS AVELINO
权利人:DUBOIS JEAN-LUC; IBORRA CHORNET SARA; VELTY ALEXANDRA I LUCIENNE; CORMA CANOS AVELINO
摘要:A method for the synthesis of cyclic acetals comprises reacting at least one carbonyl-function compound selected from aldehydes, ketones, and/or linear acetals, on a polyol in a concentrated aqueous solution exceeding 20 wt % in a reactor containing an acidic catalyst. The carbonyl-function compound is selected so that the cyclic acetal obtained has a water solubility lower than 20000 mg/kg. During the catalytic reaction for the cyclic acetal synthesis, at least one portion of the organic phase containing the cyclic acetal is separated. The acidic catalysis is either homogeneous when using a water-soluble strong acid, or heterogeneous when using a solid acid such as a resin, a zeolite, or any appropriately acidified solid. The extractive reaction method can be used for obtaining high conversions and selectivity.

专利号:US-4975519-A
优先权日:1989-05-12
标 题 :Novel polyacetal terpolymers of trioxane and alpha, alpha- and alpha, beta-isomers of glycerol formal and functional derivatives thereof
发明人：YANG NAN L; AUERBACH ANDREW; PESCE ROSE; BROUSSARD JERRY A; PAUL JAMES L
权利人:HOECHST CELANESE CORP
摘要:Cationic polymerization of trioxane and a mixture of ester derivatives of α,α- and α,β-isomers of glycerol formal yields acetal terpolymers having pendant functional groups (i.e., ester groups, or hydroxyl groups obtained by hydrolyzing ester groups, pendent from the polymer's backbone). The glycerol formal monomers employed in this invention may include functional groups selected from ester moieties which are protected from, and thus survive, the polymerization process with trioxane. These groups may then be present as functional reactive sites for the subsequent synthesis of block polymers and/or to chemically bind modifiers to the acetal terpolymer backbone, for example.

专利号:US-4466900-A
优先权日:1981-09-22
标 题:Process for the preparation of fluorescent brightener formulations which are stable on storage
发明人：HORLACHER PAUL; PFENNINGER HEINZ
权利人:CIBA GEIGY CORP
摘要:A process is described for the preparation of concentrated liquid formulations, stable on storage, of anionic fluorescent brighteners, which process consists in passing a crude (for example obtained from synthesis) aqueous solution or dispersion of a fluorescent brightener containing sulfo groups, in particular a stilbene fluorescent brightener belonging to the group comprising bistriazinylaminostilbenedisulfonic acids, bis-styrylbiphenyls, bis-styrylbenzenes and bis-triazolylstilbenedisulfonic acids, is passed through a semipermeable membrane which contains ionic groups and has a pore diameter of 1-500 ANGSTROM in order to remove salts and by-products from the synthesis having molecular weights below 500 and in order to remove part of the water. The resulting concentrated preparation can, if desired, be concentrated further and/or treated with formulation assistants and, if desired, further additives.

专利号:US-4207088-A
优先权日:1977-06-30
标题:Herbicidal 1,3-dioxanes
发明人：KONZ MARVIN J
权利人:FMC CORP
摘要:A new class of herbicidal compounds consisting of 1,3-dioxanes carrying substituents other than hydrogen in the 2-, 4-, 5-, and 6-positions of the dioxane ring exhibits preemergence and postemergence herbicidal activity, controlling effectively the growth of selected grassy species. The synthesis of members of this class is described in detail, and the utility of representative compounds in exemplified.

专利号:US-4035178-A
优先权日:1976-08-31
标 题 :Herbicidal 1,3-dioxanes
发明人：KONZ MARVIN JOSEPH
权利人:FMC CORP
摘要:A new class of herbicidal compounds consisting of 1,3-dioxanes carrying substituents other than hydrogen in the 2-, 4-, 5-, and 6-positions of the dioxane ring exhibits preemergence and postemergence herbicidal activity, controlling effectively the growth of selected grassy species. The synthesis of members of this class is described in detail, and the utility of representative compounds is exemplified.

专利号:US-4500321-A
优先权日:1980-06-04
标 题:Process for the preparation of concentrated fluid dye compositions
发明人：HUGELSHOFER PAUL; BRUTTEL BEAT; PFENNINGER HEINZ; LACROIX ROGER
权利人:CIBA GEIGY CORP
摘要:A process for the preparation of storage-stable concentrated fluid dye compositions of water-soluble dyes, wherein an aqueous solution or suspension of at least one anionic crude dye is passed over a semi-permeable membrane containing ionic groups and having a pore diameter of 1 to 500 ANGSTROM , to remove salts and synthesis by-products of molecular weights less than 500 and to partially remove water, optionally dried, and mixed with a water-miscible organic solvent and, if desired, further additives, before and/or after passage over the semi-permeable membrane. The fluid dye compositions obtained are particularly suitable for use in spray solutions for dyeing leather, as well as for the dying and printing of textile materials, in particular cellulosic fibres.