CAS: 4411-25-0; 1-Adamantylisocyanate

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CAS号768-90-1 1-溴金刚烷 | CAS号75-44-5 光气 | CAS号4648-54-8 叠氮基三甲基硅烷 | CAS号2094-72-6 1-金刚烷甲酰氯 | CAS号28309-44-6 N-hydroxyadaman... | CAS号768-95-6 1-金刚烷醇 | CAS号26496-33-3 1-adamantanoylazide | CAS号201230-82-2 carbon monoxide | CAS号5689-59-8 1-氯乙酰氨基金刚烷 | CAS号20594-58-5 Acetamide,2,2,2... | CAS号126681-79-6 (Z)-N-(1-adaman... | CAS号126681-74-1 2-(1-adamantyli... | CAS号126681-78-5 (Z)-N-(1-adaman... | CAS号126681-73-0 5-Phenyl-2-(tri... | CAS号126681-76-3 2-(1-adamantyli... | CAS号126681-81-0 (Z)-N-(1-adaman... | CAS号26496-36-6 N-(1-金刚烷)肼羧酰胺 | CAS号479413-70-2 AUDA

1-金刚烷甲酸置于4-二甲氨基吡啶,1,1,1-Trichloro-2-Methylpropan-2-Yl Azidoformate体系中,用 乙腈 作为反应溶剂,化学反应生成 异氰酸1-金刚烷酯
参考文献:使用 1,1-二甲基-2,2,2-三氯乙氧基羰基叠氮化物的 Dmap 催化一锅 Curtius 重排
标题:使用 1,1-二甲基-2,2,2-三氯乙氧基羰基叠氮化物的 Dmap 催化一锅 Curtius 重排
摘要:我们报告了使用 1,1-二甲基-2,2,2-三氯乙氧基羰基叠氮化物 (Dmtn 3) 和 4-(二甲氨基)吡啶 (Dmap) 作为催化剂开发的可控,无碱,一锅 Curtius 重排.该催化过程的范围涵盖一系列伯,仲和叔烷基和芳基羧酸,可实现烷基或芳基异氰酸酯的有效立体有择构造.报道了天然产物和药物分子的后期脱羧异氰化,几种药物的快速合成以及原位反应生成的 Dmtn 3的利用的例子.对该机理的详细研究表明,反应速率取决于dmap催化剂的浓度,这确保了反应是一个温和且可控的过程.
DOI:10.1021/acs.Orglett.3C01580

专利信息

专利号:US-12338202-B2
优先权日:2021-09-10
标 题 :One pot synthesis of urea (meth)acrylates
发明人：BESTGEN SEBASTIAN; BEYER SILVIA
权利人:EVONIK OPERATIONS GMBH
摘要:A one-pot synthesis of polymerizable and acyclic urea (meth)acrylates, preferably mono(meth)acrylates, can be performed via in-situ synthesis of urea alcohols or amines followed by direct reaction with a (meth)acrylate reactive diluent. The urea alcohol/amine is obtained from isocyanates and alcohols, amines, or hydroxyamines. Subsequently, the reaction with the (meth)acrylate reactive diluent takes place and the urea (meth)acrylate is directly obtained either in solution with the reactive diluent, or as a pure material after removal of the reactive diluent.

专利号:US-11655255-B2
优先权日:2022-10-17
标题 :Method for catalytic asymmetric synthesis of phosphorus-stereogenic (P-stereogenic) nucleoside derivative and catalyst used therein
发明人：ZHANG WANBIN; WANG MO; ZHANG LU; HUO XIAOHONG; ZHANG ZHENFENG; YUAN QIANJIA; CHEN JIANZHONG
权利人:SPH NO 1 BIOCHEMICAL & PHARMACEUTICAL CO LTD; UNIV SHANGHAI JIAOTONG
摘要:A method for catalytic asymmetric synthesis of a phosphorus-stereogenic (P-stereogenic) nucleoside derivative of formula (3) and a catalyst used therein. The P-stereogenic nucleoside derivative (3) can be hydrolyzed to obtain remdesivir. Specifically, a nucleoside and phosphoryl chloride are subjected to asymmetric reaction under the catalysis of a chiral bicyclic imidazole catalyst in the presence of a base to produce the P-stereogenic nucleoside derivative of formula (3)

专利号:US-3933830-A
优先权日:1974-09-10
标 题 :Process for the synthesis of 4-(2-pyridylamido ethyl) piperidines
发明人：BARTH WAYNE E; KUHLA DONALD E
权利人:PFIZER
摘要:Disclosed herein is an improved process for the preparation of known hypoglycemic piperidinesulfamylureas of the structure ##EQU1## wherein R is selected from the group consisting of 3-(2-methoxy)pyridyl, 3-(2-ethoxy)pyridyl and 2-(4-chloro)pyridyl and R' is selected from the group consisting of bicyclo[2.2.1]hept-5-en-2-yl-endo-methyl, bicyclo[2.2.1]hept-2-yl-endo-methyl, 7-oxabicyclo[2.2.1]hept-2-yl-methyl, 1-adamantyl and cycloalkyl having from five to eight carbon atoms. n Said process comprises contacting 4-(2-pyridyl-amidoethyl) piperidine of the structure ##EQU2## with substantially one equivalent of sulfamide thereby exclusively sulfonating the piperidine nitrogen atom. Said 4-(2-pyridylamidoethyl)piperidines from the corresponding 4-(2-pyridylamidoethyl) pyridines by selectively activating the more basic nitrogen atom of said pyridine compound either by N-alkylation or by contact with acid and then exclusively reducing the activated pyridine ring with either hydrogen alone or in combination with a metal hydride. Said 4-(2-pyridylamidoethyl)pyridines are produced by contacting 4-(2-aminoethyl)pyridine with a pyridyl acid chloride of the formula R(C=O)Cl. The piperidine sulfonamides produced by the process of the instant invention are converted to the desired hypoglycemic agent by methods well-known to those skilled in the art. n The 4-(2-pyridylamidoethyl)pyridines and piperidines of the instant invention are themselves novel compounds useful as intermediates in the synthesis of piperidine sulfamylurea hypoglycemic agents.

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-2023381761-A1
优先权日:2020-10-08
标 题 :Catalysts and their uses in one-pot diastereoselective synthesis of remdesivir