CAS: 4238-71-5; 1-Benzyl-1H-Imidazole

该化合物是一种有机化合物,其特征为:一环是五人组成的含有两个氮原子的环形环形结构;该化合物的特征是附于一氮原子氮的苯基组,其化学特性得到加强;该化合物通常是白色的,在非白色固体中溶解,但水中溶解性有限;一环是氮原子在环形中存在的基本特性,允许其参与各种化学反应,包括核生殖器替代和与金属离子的协调;该化合物通常用于有机合成,并用作制药和农用化学品开发的建筑块;此外,其衍生物可能展示生物活动,使其对医药化学感兴趣;在处理和储存时,应参考安全数据,如任何化学物质,以确保采取适当的防范措施.

英文名称1-Benzyl-1H-Imidazole
中文名称1-苄基-1H-咪唑
IUPAC名称1-benzyl-1H-imidazole
其它别名苄基咪唑; 1苄基咪唑
CAS编号4238-71-5
MFCD编号:MFCD00005296
EINECS号:224-200-4
FDA UNII编号:W4C9Z5BCV7
分子式:C10H10N2
分子量:158.2
产品CID: 1436974
产品分类有机原料→分子砌块→芳杂环类化合物→咪唑类化合物

相似结构搜索
产品信息参考;;;;
InChIKey: KKKDZZRICRFGSD-UHFFFAOYSA-N
InChI=1S/C10H10N2/c1-2-4-10(5-3-1)8-12-7-6-11-9-12/h1-7,9H,8H2…
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数2.0

相似化合物

1546-79-8 15469-97-3 2232-08-8

物理性质

熔点68-73°C
沸点310°C at 760 mmHg
闪点141.3±19.3 °C
密度1.0±0.1 g/cm3
pKa:6.79±0.10(预测)
PSA:17.82
LogP:1.9314
折射率1.580
蒸汽压0.0±0.6 mmHg at 25°C
溶解性DMF: >530 μg/ml; DMSO: >560 μg/ml; Ethanol: >500 μg/ml; Pbs Ph 7.2: >6.5 mg/mL
敏感性常温常压下稳定，白色至浅黄色粉末
外观形态淡棕色晶体
储存条件密封, 常温干燥保存
产品应用该化合物用作实验室有机合成的有机中间体.

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别皮肤腐蚀/刺激类别2
严重眼刺激类别2
特定目标器官毒性 - 单次接触类别3
严重眼刺激类别2A
警示词Warning(警告)
危险描述H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H335 |可能引起呼吸道刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
UN编号NONH for all modes of transport
危险品标志Xi
安全声明22-24/25
危险类别码36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

1-(4-Methoxybenzoyl)-Imidazole置于sodium Carbonate体系中,用水,乙腈作为反应溶剂,化学反应生成 N-苄基咪唑
参考文献:An Improved And Convenient Procedure For The Synthesis Of 1-Substituted Imidazoles.
标题:An Improved And Convenient Procedure For The Synthesis Of 1-Substituted Imidazoles.
摘要:1-保护的咪唑类化合物,如1-乙酰咪唑和1-苯甲酰咪唑,与各种卤化物反应,如苄基,烯丙基,α-酮和烷基卤化物,能够高产率地得到1-保护的3-取代咪唑鎓盐.所得到的咪唑鎓盐可以通过水或醇处理轻易去保护,进而获得相应的1-取代咪唑类化合物,产率极高.在这个反应中,1-取代咪唑的产率因所使用的卤化物种类和/或保护基团的不同而变化,产率按以下顺序递增:苄基卤化物 >= 烯丙基卤化物 ∼ α-酮卤化物 < 烷基卤化物,并且乙酰基 >= 苯甲酰基 < 乙氧羰基 < 二乙氧基甲基 < 三甲基硅基 < 对甲苯磺酰基.
DOI:10.1248/cpb.31.1213

海关参考信息

2902300000-甲苯
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:EP-0310950-B1
优先权日:1983-11-18
标题 :Quinoline intermediates for the synthesis of 1H-imidazo[4,5-c]quinolines and 1H-imidazo[4,5-c]quinolin-4-amimes
摘要:Compounds of the types (I) and (II) are disclosed, wherein each R5 is independently selected from the group consisting of alkyl of one to about four carbon atoms, alkoxy of one to about four carbon atoms and halogen, and n is an integer from 0 to 2, with the proviso that if n is 2, then said R5 substituents together contain no more than 6 carbon atoms; R6 is selected from the group consisting of hydroxyalkyl of one to about six carbon atoms and cyclohexylmethyl; and R7 is selected from the group consisting of alkyl of one to about four carbon atoms and hydrogen. These compounds may be used as intermediates for the synthesis of 1H-imidazo[4,5-c]quinoline derivatives.

专利号:US-7259263-B2
优先权日:2005-06-29
标题:Method of synthesis of azole-containing amino acids
发明人：HLASTA DENNIS J; ZIFICSAK CRAIG A
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention relates to methods of synthesizing 2-substituted azole compunds of formula (I): n nThe invention is also relates to compounds of formula (I) and to intermediate compounds in the synthesis method.

专利号:US-10821431-B1
优先权日:2019-04-16
标题 :Aluminum-substituted CIT-15, its synthesis and use
发明人：LEW CHRISTOPHER MICHAEL; JENSEN KURT OWEN
权利人:CHEVRON USA INC
摘要:A method is provided for the synthesis of aluminum-containing forms of molecular sieve CIT-15. The method includes treating an aluminogermanosilicate CIT-13 molecular sieve with water under conditions sufficient to degermanate at least a portion of the aluminogermanosilicate CIT-13 molecular sieve to provide a phyllosilicate comprising delaminated cfi-layers; and calcining the phyllosilicate under conditions sufficient to convert the phyllosilicate to an aluminogermanosilicate CIT-15 molecular sieve.

专利号:US-2006051291-A1
优先权日:2004-09-07
标题 :Synthesis of radiolabeled sugar metal complexes
发明人：ADAM MICHAEL J; FISHER CARA L; BAYLY SIMON R; ORVIG CHRISTOPHER; LIM NATHANIEL C; STORR TIMOTHY J; EWART CHARLES B
权利人:ADAM MICHAEL J; FISHER CARA L; BAYLY SIMON R; ORVIG CHRISTOPHER; LIM NATHANIEL C; STORR TIMOTHY J; EWART CHARLES B
摘要:The invention provides a method for manufacturing or preparing neutral, low molecular weight 99m Tc-labeled and 186 Re-labeled carbohydrate complexes with an improved radiochemical yield from a simple functionalized sugar, such as glucosamine. In particular the synthesis relies on single ligand transfer (SLT) or double ligand transfer (DLT) reactions for converting a ferrocene compound into a rhenium or technetium tricarbonyl complex. The ferrocene compound may be linked to a sugar through various functional groups including, for example, thio, amino and alcohol functionalities to provide a wide range of radiolabeled sugar complexes that include both water soluble and relatively water insoluble compounds.

专利号:US-8093397-B2
优先权日:2001-07-03
标题:Activators for oligonucleotide synthesis
发明人：SINHA NANDA; ZEDALIS WILLIAM EDWARD; MIRANDA GREGORY KEITH
权利人:SINHA NANDA; ZEDALIS WILLIAM EDWARD; MIRANDA GREGORY KEITH; AVECIA BIOTECHNOLOGY INC
摘要:A process for the synthesis of oligonucleotides using phosphoramidite chemistry is provided. The process employs as activator a 1,1-dioxo-1,2-dihydro-1Î»6-benzo[d]isothiazol-3-one, preferably in the presence of an organic base. The 1,1-dioxo-1,2-dihydro-1Î»6-benzo[d]isothiazol-3-one is represented by the following structural formula: wherein p is 0 or an integer from 1 to 4; X7 is O or S; R for each occurrence is a substituent, preferably each independently, a halo, a substituted or unsubstituted aliphatic group, â€”NR11R12, â€”OR13, â€”OC(O)R13, â€”C(O)OR13, or cyano; or two adjacent R groups taken together with the carbon atoms to which they are attached form a six membered saturated or unsaturated ring; R11 and R12 are each, independently, â€”H, a substituted or unsubstituted aliphatic group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aralkyl group; and R13 is a substituted or unsubstituted aliphatic group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aralkyl group. Preferred organic bases are pyridine, 3-methylpyridine, or N-methylimidazole.

专利号:EP-1904465-B1
优先权日:2005-06-29
标题 :Method of synthesis of imidazole-amino acid derivatives and related compounds
发明人：HLASTA DENNIS J; ZIFICSAK CRAIG A
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention relates to methods of synthesizing 2-substituted azole compunds of formula (I). The invention is also relates to compounds of formula (I) and to intermediate compounds in the synthesis method.

其他信息查阅

河北凯诺中星科技有限公司

网址: http://www.chiralst.com
企业联系电话：15127158185👤
地址:河北省石家庄市循环化工园区工业大街156号

⚠️ 未注册 · 未认证企业

备注: 📌 数据来源说明：本展台内容基于各搜索引擎等公开数据整理，仅作展示用途。请用户自行辨别
✉️ 若企业需抹除展台内容或有异议，请通过页面底部联系方式告知我们，我们会尽快处理。

宁波冀凯科技有限公司

网址: http://www.nbchiralst.com
企业联系电话：13186879657👤
地址:浙江省宁波高新区菁华路188号(甬港现代铭楼)B座041幢1楼1-1324室

⚠️ 未注册 · 未认证企业

南京冀凯科技有限公司

网址: http://www.njchiralst.com
企业联系电话：13151575853👤
地址:南京市雨花台区凤汇大道16号1幢380室

⚠️ 未注册 · 未认证企业

安徽省金奥化工有限公司

网址: http://www.ahjachem.com
企业联系电话：0551-63450295;13505511751👤
地址:安徽合肥市包河区马鞍山南路760号

⚠️ 未注册 · 未认证企业

济南新达化工有限公司

网址: http://www.jnxdchem.com
企业联系电话：0531-84212239👤
地址:山东省济南市济阳区济北街道仁和街30号

⚠️ 未注册 · 未认证企业

上海凯乐实业发展有限公司

网址: http://www.klpharm.com
电话: 13951225358👤

⚠️ 未注册 · 未认证企业

备注: 📌 数据来源说明：本展台内容基于各搜索引擎等公开数据整理，仅作展示用途。请用户自行辨别 ✉️ 若企业需抹除展台内容或有异议，请通过页面底部联系方式告知我们，我们会尽快处理。

宁波市海曙铭浩医药化工有限公司

网址: http://www.mhpharm.com.cn
企业联系电话：0574-88285925👤
地址:宁波市海曙区横街镇金泉路3号

⚠️ 未注册 · 未认证企业

上海灏云化工科技有限公司

网址: http://www.haoyunchem.com
企业联系电话：021-68367562,68369562,15002147577👤
地址:上海市浦东新区沈梅路123弄3号楼808室

⚠️ 未注册 · 未认证企业

潍坊市鸣冉化工有限公司

网址: http://www.mingranchem.cn
企业联系电话：0536-2082396;15063661899👤
地址:山东省潍坊市高新技术产业开发区

⚠️ 未注册 · 未认证企业

江西金凯化工有限公司

网址: https://jximidazole.cn/
电话:0794-5212228👤
江西省，抚州市金溪县对桥工业园

⚠️ 未注册 · 未认证企业

备注: 数据来源说明：本展台内容基于各搜索引擎等公开数据整理，仅作展示用途。请用户自行辨别. 若企业需抹除展台内容或有异议，请通过页面底部联系方式告知我们，我们会尽快处理。

常州市中凯化工有限公司

网址: http://www.chongkai.com
电话:0519-85109358👤
江苏省常州市新北区高新科技园北区428号

⚠️ 未注册 · 未认证企业

第 1 / 1 页

现货

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: Magdalou J, Totis M, Boiteux-Antoine Af, Et Al. Effect Of 1-Benzylimidazole On Cytochromes P-450 Induction And On The Activities Of Epoxy Hydrolases And Udp-Glucuronosyltransferases In Rat Liver[参考文献]: Biochemical Pharmacology, 1988, 37(17): 3297-330 Shen Rf, Tai H H. Thromboxanes: Synthase And Receptors[参考文献]: Journal Of Biomedical Science , 1998, 5(3): 153-17
[参考文献]: Navas Jm, Chana A, Herradón B, Et Al. Induction Of Cyp1A By The N‐imidazole Derivative, 1‐benzylimidazole[参考文献]: Environmental Toxicity And Chemistry, 2003, 22(4): 830-83
[参考文献]: Pettigrew Lc, Grotta Jc, Rhoades Hm, Et Al. Effect Of Thromboxane Synthase Inhibition On Eicosanoid Levels And Blood Flow In Ischemic Rat Brain[参考文献]: Stroke, 1989, 20(5): 627-632
[参考文献]: Shen Rf, Tai H H. Thromboxanes: Synthase And Receptors[参考文献]: Journal Of Biomedical Science, 1998, 5(3): 153-17
[参考文献]: Adel Mostafa, Et Al. Synthesis And Spectroscopic Studies On Charge-Transfer Molecular Complexes Formed In The Reaction Of Imidazole And 1-Benzylimidazole With σ- And π-Acceptors. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Sep;79(5):1613-20.

合成参考文献

摘要:Vaultier, M.; Pucheault, M., Science of Synthesis Knowledge Updates, (2012) 4, 332.
摘要:Scammells, P. J., Science of Synthesis Knowledge Updates, (2013) 2, 434.
摘要:Shaabani, A.; Sarvary, A.; Shaabani, S., Science of Synthesis: Multicomponent Reactions, (2013) 2, 103.
摘要:Nakao, Y., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 367.
摘要:Nakao, Y., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 355.

📝 需求与反馈

📲 手机号 / 邮箱 *

✏️ 问题内容 *

尽可能描述清楚需求与问题信息

CAS: 4238-71-5; 1-Benzyl-1H-Imidazole

相似化合物

物理性质

MSDS等安全信息

欧盟法规

上下游产品

合成工艺路线路线简述

海关参考信息

专利信息

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

📌 第三方产品分析报告

主要参考文献

合成参考文献

通知